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Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
Published 2022“…Vaccinating diabetic patients against influenza would significantly reduce hospitalization due to disease severity. …”
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Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
Published 2017“…Thus, the aim of this review is to discuss the upstream regulators and the downstream effectors of Sestrins and to highlight the significance of Sestrin2 as a biomarker and a therapeutic target in diseases such as metabolic disorders, cardiovascular and neurodegenerative diseases, and cancer.…”
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The impact of maternal care on child development
Published 2019“…Studying heterogeneous effects reveals a differential impact by child's age. An increase of 6.5 h per week in the time 2-year-olds spend with their mothers significantly improves their non-cognitive skills.…”
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Gut Microbiota in Familial Mediterranean Fever: Insights into Microbial Patterns and Disease Severity
Published 2025“…Our findings revealed no significant differences in gut microbiota composition or diversity between FMF patients and healthy controls, nor among FMF subgroups stratified by disease severity. …”
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25
Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease
Published 2015“…For patients not sufficiently controlled on a single long-acting bronchodilator, a combination of different bronchodilators has shown a significant increase in lung function. Tiotropium, a once-daily dosing LAMA, demonstrated sustained improvements in lung function as well as improved health-related quality of life, reduced exacerbations, and increased survival without altering the rate of decline in the mean forced expiratory volume in 1 second (FEV1) with fairly tolerable side effects. …”
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Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease
Published 2023“…<p dir="ltr">Alzheimer disease (AD) is a leading cause of dementia in elderly patients who continue to live between 3 and 11 years of diagnosis. …”
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Systematic analysis of healthcare big data analytics for efficient care and disease diagnosing
Published 2022“…It contains a gigantic amount of data, especially a plethora of data types that has been significantly useful in diverse research domains. In healthcare domain, the researchers use computational devices to extract enriched relevant information from this data and develop smart applications to solve real-life problems in a timely fashion. …”
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Air pollution burden of disease over highly populated states in the Middle East
Published 2023“…</p><h3>Conclusions </h3><p dir="ltr">The results indicate a significant impact of air pollution due to long-term exposure to fine particles resulting in early mortality. …”
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Trends of the Dementia Burden in South Asia: An Analysis of 2021 Global Burden of Disease Study
Published 2025“…While prevalence rates experienced a minor decline, Disability‐Adjusted Life Years (DALYs) rose from 272.02 to 308.27 per 100,000, reflecting an increasing burden of the disease. Notably, Nepal significantly reduced its incidence rates, while Pakistan saw an increase in mortality rates. …”
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Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway
Published 2022“…Further treatment with 200 nM Ex-4 for 3 h significantly reduced the OA-induced lipid accumulation (p < 0.05). …”
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The Impact of Employee Engagement on Turnover Intention and Burnout
Published 2021“…Employee engagement has been the center of attention for a long period because of the significant positive impact that it exerts on work-related outcomes of employees. …”
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masterThesis -
32
Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease
Published 2012“…Pancreatic tumors are usually diagnosed at an advanced stage in the progression of the disease, thus reducing the survival chances of the patients. …”
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Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis...
Published 2021“…</p><p><br></p><h3>Methods</h3><p dir="ltr">We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. …”
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The role of preoperative transfusion in sickle cell disease, a systematic review and meta-analysis
Published 2024“…Notably, the increased bleeding risk observed seldom had clinical significance. We recommend individualizing management strategies, considering the overall positive impact of transfusions in reducing complications. …”
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Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease
Published 2015“…This treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. …”
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Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation study
Published 2024“…Pyruvic acid and valine were consistently reduced in the discovery and validation cohorts. Pathway analysis of significantly altered metabolites in the validation set revealed that they are involved in branched-chain amino acids (BCAAs) and energy metabolism (glycolysis and gluconeogenesis). …”
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Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity
Published 2022“…Functional enrichment analysis revealed long-chain polyunsaturated fatty acids (n-3 and n-6) as the pathway exhibiting the most significant changes with increased disease severity in hypertensive patients (FDR = 0.07).…”
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The effect of Dopamine Agonists on patients with advanced Parkinson's disease subjected to subthalamic deep brain stimulation. (c2000)
Published 2000“…Striatal dopamine concentration gets significantly reduced, and clinical symptoms, especially the motor handicap, prevail. …”
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40
Pill-burden and its association with treatment burden among patients with advanced stages of chronic kidney disease
Published 2023“…IntroductionChronic kidney disease (CKD) is associated with multimorbidity and high treatment burden. …”
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