Western diet induces mild metabolic impairment and aggravates neuropathology in an experimental mouse model of traumatic brain injury حسب Judith, Nwaiwu

"…Nevertheless, this was associated with neuroinflammation and impaired cognitive functions. However, there was no significant impact on cardiovascular function and mitochondrial bioenergetics. …"
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Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors حسب Noura Aldous (15429873)

"…Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …"

Effects of visual field impairment on driving حسب Jan Andersson (218600)

"…When the results from a secondary trial for drivers visual impairments were compared the normal sighted drivers’ first try the differences decreased but were still statistical significant. …"

Enoxaparin 20 mg for thromboprophylaxis in severe renal impairment حسب Karaoui, Lamis R.

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Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia حسب Hanan Ehtewish (17149825)

"…And 20 proteins had significantly altered autoantibody responses in MCI compared to cognitively normal individuals. …"

Accessibility first: detecting frustration in web browsing for visually impaired and sighted smartphone users حسب Yasmin Abdelaal (17773458)

"…Smartphones pose numerous challenges to individuals with visual impairments (VI). This is due to smaller screen sizes, lack of physical buttons, and prevalent problems. …"

Prevalence and risk of cognitive impairment among patients with asthma: A systematic review and meta‐analysis حسب Ganesh Bushi (19709574)

"…The pooled prevalence of cognitive impairment in patients with asthma was 16.3%. The analysis also revealed an increased hazard ratio of 1.47 (95% confidence interval [1.09; 1.84]) for cognitive impairment in patients with asthma compared to the control group (individuals without asthma). …"

Dextran Sodium Sulfate-Induced Impairment of Protein Trafficking and Alterations in Membrane Composition in Intestinal Caco-2 Cell Line حسب Toutounji, Mohamad

"…The present study investigates endoplasmic reticulum (ER) stress in addition to alterations in protein and membrane trafficking in a dextran sulfate sodium (DSS)-induced IBD-like phenotype of intestinal Caco-2 cells in culture. DSS treatment significantly reduced the transepithelial electric resistance (TEER) and increased the epithelial permeability of Caco-2 cells, without affecting their viability. …"
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High phosphorus diet mitigates impairments in lipid and glucose metabolism associated with diet-induced obesity in male sprague dawley rats حسب Bassil, Maya

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Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes حسب Hoda, Gad

"…AimCardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability (GV) in patients with type 1 and type 2 diabetes. …"
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Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes حسب Hoda Gad (6470522)

"…<h3>Aim</h3><p dir="ltr">Cardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability (GV) in patients with type 1 and type 2 diabetes.…"

COVID-19 mothers’ mother–baby bonding, feeding practices, postnatal care experiences in Qatar: A mixed-methods approach حسب laura Moya falcon (22556218)

"…</p><h3>Conclusions</h3><p dir="ltr">The pandemic has significantly impacted maternal–infant bonding, as evidenced by increased reports of maternal stress, reduced physical contact, and limitations on partner support. …"

Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... حسب Abdoulaye Diane (14152749)

"…Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…"

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss حسب Meritxell Espino Guarch (18810097)

Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59 حسب Ramada R. Khaswaneh (22224544)

"…</p><h3>Results</h3><p dir="ltr">Our results showed for the first time that severe hypoxia can significantly impair Factor H secretion and CD59 expression in MSCs. …"

Qatar’s immigrants at higher risk of diabetes حسب Nature Research (16552612)

"…The results, however, suggest that Qatar’s immigrant population has a significantly increased risk of having undiagnosed T2D, and that glycated haemoglobin levels could be a useful diagnostic tool for early detection of the disease. …"

Chemotherapy With Bevacizumab Does Not Affect Liver Regeneration After Portal Vein Embolization in the Treatment of Colorectal Liver Metastases حسب Zorzi, Daria

"…Background Blockage of vascular endothelial growth factor (VEGF) in murine models has been shown to impair liver regeneration after partial hepatectomy. …"
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Growth hormone treatment modulates active ghrelin levels in rats حسب Haddad, Haytham

"…Genotropin treatment caused a dose dependent decrease in active ghrelin concentration in stomach, kidney and pancreas with a concomitant increase in plasma, and reaching significance at 20 and 100 µg/rat/day doses. …"
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Loan guarantee, management earnings forecasts and cost of debt: evidence from Chinese manufacturing firms حسب Muhammad Bilal Khan (8960918)

"…However, a positive relationship between information asymmetry measures and loan guarantees is more pronounced, suggesting that loan guarantees reduce the significance of information asymmetry issues, which impair borrowing firms’ re-payment ability and increase the credit risk of guarantors and banks. …"

Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer حسب Adviti Naik (673163)

"…Following <i>LDHC</i> knockdown, we observed an increase in the secretion of tumor-derived pro-inflammatory cytokines (IFN-γ, GM-CSF, MCP-1, CXCL1), a decrease in the soluble levels of tumor-derived immunosuppressive factors (IL-6, Gal-9) and reduced tumor cell surface PD-L1 expression. …"