Western diet induces mild metabolic impairment and aggravates neuropathology in an experimental mouse model of traumatic brain injury by Judith, Nwaiwu

“…Nevertheless, this was associated with neuroinflammation and impaired cognitive functions. However, there was no significant impact on cardiovascular function and mitochondrial bioenergetics. …”
Get full text
Get full text
Get full text

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors by Noura Aldous (15429873)

“…Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …”

Effects of visual field impairment on driving by Jan Andersson (218600)

“…When the results from a secondary trial for drivers visual impairments were compared the normal sighted drivers’ first try the differences decreased but were still statistical significant. …”

Enoxaparin 20 mg for thromboprophylaxis in severe renal impairment by Karaoui, Lamis R.

Get full text
Get full text
Get full text
Get full text

Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia by Hanan Ehtewish (17149825)

“…And 20 proteins had significantly altered autoantibody responses in MCI compared to cognitively normal individuals. …”

Accessibility first: detecting frustration in web browsing for visually impaired and sighted smartphone users by Yasmin Abdelaal (17773458)

“…<p dir="ltr">Smartphone adoption has become increasingly prevalent in modern society, reflecting the widespread integration of these devices into various aspects of daily life, yet accessibility and usability problems persist. …”

COVID-19 mothers’ mother–baby bonding, feeding practices, postnatal care experiences in Qatar: A mixed-methods approach by laura Moya falcon (22556218)

“…</p><h3>Conclusions</h3><p dir="ltr">The pandemic has significantly impacted maternal–infant bonding, as evidenced by increased reports of maternal stress, reduced physical contact, and limitations on partner support. …”

Prevalence and risk of cognitive impairment among patients with asthma: A systematic review and meta‐analysis by Ganesh Bushi (19709574)

“…The pooled prevalence of cognitive impairment in patients with asthma was 16.3%. The analysis also revealed an increased hazard ratio of 1.47 (95% confidence interval [1.09; 1.84]) for cognitive impairment in patients with asthma compared to the control group (individuals without asthma). …”

Dextran Sodium Sulfate-Induced Impairment of Protein Trafficking and Alterations in Membrane Composition in Intestinal Caco-2 Cell Line by Toutounji, Mohamad

“…The present study investigates endoplasmic reticulum (ER) stress in addition to alterations in protein and membrane trafficking in a dextran sulfate sodium (DSS)-induced IBD-like phenotype of intestinal Caco-2 cells in culture. DSS treatment significantly reduced the transepithelial electric resistance (TEER) and increased the epithelial permeability of Caco-2 cells, without affecting their viability. …”
Get full text
Get full text
Get full text
Get full text

High phosphorus diet mitigates impairments in lipid and glucose metabolism associated with diet-induced obesity in male sprague dawley rats by Bassil, Maya

Get full text
Get full text
Get full text

Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes by Hoda, Gad

“…AimCardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability (GV) in patients with type 1 and type 2 diabetes. …”
Get full text
Get full text
Get full text

Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes by Hoda Gad (6470522)

“…The percentage GRADEEuglycemia (3.30 ± 2.78 vs. 5.69 ± 3.09, P = 0.017) and GRADEHypoglycemia (0.3 (range: 0 – 3.80) vs. 1.8 (range: 0.9–6.5), P = 0.036) were significantly lower, while the percentage median GRADEHyperglycemia (95.45 (range:93–98) vs. 91.6 (82.8–95.1), P = 0.013) was significantly higher in participants with CAN compared to those without CAN.…”

Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... by Abdoulaye Diane (14152749)

“…Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…”

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss by Meritxell Espino Guarch (18810097)

Qatar’s immigrants at higher risk of diabetes by Nature Research (16552612)

“…The results, however, suggest that Qatar’s immigrant population has a significantly increased risk of having undiagnosed T2D, and that glycated haemoglobin levels could be a useful diagnostic tool for early detection of the disease. …”

Aorta deformation linked to heart disease by Nature Research (16552612)

“…They found that the mechanics of the aorta were altered, with the pulsatile change in aortic diameter, distention and elasticity of the aortic walls being significantly decreased, and aortic stiffness significantly increased, in HCM patients compared to the controls. …”

Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model by Sahar Isa Da’as (18288880)

“…These knockout zebrafish displayed significant morphological heart alterations related to a significant decrease in ventricular and atrial diameters at systolic and diastolic states at the larval stages. …”

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death by Tohme, Sara

“…Scavenging ROS using NAC significantly decreases cell death but has minimal effect on autophagy activation, suggesting that the accumulation of ROS is downstream of autophagy activation but upstream of cell death. …”
Get full text
Get full text
Get full text

Effect of chronic and non-chronic moderate wine consumption upon rat lipoprotein profile in the blood. (c2002) by Slaiby, Rita

Get full text
Get full text

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy by Jia-Zhen Wu (6844793)

“…<h3>Background</h3><p dir="ltr">Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggregation <i>in vitro</i> and <i>in vivo</i>. …”