Table 8_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Data Sheet 1_Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells.doc by Koki Chiba (5413028)

“…Knockdown of PFKFB3 or pharmacological inhibition of glycolysis resulted in decreased insulin secretion and impaired glucose tolerance. …”

Image_1_Evaluation of bone mineral density and bone turnover in children on anticoagulation.pdf by Katharina Thom (16723107)

“…Significant associations were found between early pubertal development and TBLH-BMD, and between BMI and LS-BMD. …”

Table_1_Mortality and survival in nonagenarians during the COVID-19 pandemic: Unstable equilibrium of aging.docx by Daria A. Kashtanova (14704042)

“…</p>Results<p>The most reliable predictors of overall mortality were cognitive impairment, malnutrition, frailty, aging-associated diseases and blood markers indicating malnutrition-induced metabolic dysfunctions (decreased levels of protein fractions, iron, 25-hydroxyvitamin D, and HDL), and aging biomarkers, such as IGF-1 and N-terminal pro b-type natriuretic peptide. …”

Table 1_Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegenerati... by Menekse Oeztuerk (20756606)

“…Our proteomic analysis revealed AFG3L2 impairment, with significant dysregulation of proteins critical for mitochondrial function, cytoskeletal integrity, and cellular metabolism. …”

Data_Sheet_2_Measuring the effect of the anti-nerve growth factor antibodies bedinvetmab and frunevetmab on quality of life in dogs and cats with osteoarthritis using a validated h... by Jacqueline Reid (7400972)

“…Background<p>Osteoarthritis causes chronic pain, impaired joint function, decreased mobility and negatively impacts quality of life (QOL). …”

Data_Sheet_1_Measuring the effect of the anti-nerve growth factor antibodies bedinvetmab and frunevetmab on quality of life in dogs and cats with osteoarthritis using a validated h... by Jacqueline Reid (7400972)

“…Background<p>Osteoarthritis causes chronic pain, impaired joint function, decreased mobility and negatively impacts quality of life (QOL). …”

Data_Sheet_1_Measuring the effect of the anti-nerve growth factor antibodies bedinvetmab and frunevetmab on quality of life in dogs and cats with osteoarthritis using a validated h... by Jacqueline Reid (7400972)

“…Background<p>Osteoarthritis causes chronic pain, impaired joint function, decreased mobility and negatively impacts quality of life (QOL). …”

Image 1_Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegenerati... by Menekse Oeztuerk (20756606)

“…Our proteomic analysis revealed AFG3L2 impairment, with significant dysregulation of proteins critical for mitochondrial function, cytoskeletal integrity, and cellular metabolism. …”

Table_1_Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study.XLSX by Fan Yang (1413)

“…Introduction<p>Numerous studies have suggested a connection between circadian rhythm and neurological disorders with cognitive and consciousness impairments in humans, yet little evidence stands for a causal relationship between circadian rhythm and the brain cortex.…”

Strain Specific Responses in a Microbead Rat Model of Experimental Glaucoma by Karen Eastlake (9302786)

“…This correlated with a significant impairment of RGC function, as determined by scotopic ERG (<i>p</i> < .001), reduction in axon number (<i>p</i> < .05) and lower RGC density (<i>P</i> < .05) in animals receiving 20 mg or 10 mg microspheres/ml as compared with controls. …”

<b>Role of the Chaperone ClpB in</b><b> </b><b>Mycoplasma bovis</b><b> Virulence: Implications for </b><b>stress response, a</b><b>dhesion, </b><b>b</b><b>iofilm </b><b>d</b><b>eve... by Hui zhang (22187170)

“…Phenotypic characterization revealed that ClpB disruption attenuated key virulence attributes, including: impaired host cell adhesion capacity, significant reduction in biofilm formation (p<0.01), diminished induction of proinflammatory cytokines (IL-1β, IL-6, TNF-α) in infected BoMac cells, decreased extracellular nuclease activity. …”

Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability (Sup Tables). Berthier et al. J. Hepatol. 2025 by Alexandre Berthier (16876311)

“…Insulin resistance (IR) can impair MetF, contributing to type 2 diabetes and obesity. …”

Table_1_LncRNA GAS5 represses stemness and malignancy of gliomas via elevating the SPACA6-miR-125a/let-7e Axis.xlsx by Shuang Wu (148427)

“…In this study, we explored the clinical significance, biological function, and underlying mechanisms of GAS5 in GBM. …”

DataSheet_1_LncRNA GAS5 represses stemness and malignancy of gliomas via elevating the SPACA6-miR-125a/let-7e Axis.pdf by Shuang Wu (148427)

“…In this study, we explored the clinical significance, biological function, and underlying mechanisms of GAS5 in GBM. …”

Data_Sheet_1_Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer’s Disease Continuum.docx by Yi-He Chen (11239692)

“…Baseline brain volumes (including the hippocampal, entorhinal, middle temporal lobe, and whole-brain) decreased in MCI and AD groups. For the longitudinal study, there were significant interaction effects of CSF p-tau181 × time, plasma p-tau181 × time, CSF sTREM2 × time, and brain volumes × time, indicating CSF, and plasma p-tau181, CSF sTREM2, and brain volumes could predict longitudinal cognition deterioration rate. …”

Data_Sheet_1_Altered Vascular Adaptations to Pregnancy in a Rat Model of Advanced Maternal Age.pdf by Mazhar Pasha (11197767)

“…MCh responses were not different, however, L-NAME decreased maximum vasodilation in young (p < 0.01) and aged pregnant rats (p < 0.001), and decreased MCh sensitivity in young non-pregnant rats (p < 0.01), without effects in aged non-pregnant rats. …”

Table_1_Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool.DOCX by Ruili Li (470065)

“…However, there was a significant difference between ANI and NCs in the relative volumes of the bilateral caudate and lateral ventricle.…”

Caregiver-mediated exercises with e-health support for early supported discharge after stroke (CARE4STROKE): A randomized controlled trial by Judith D. M. Vloothuis (6565049)

“…Decreased anxiety in patients remained significant at the 12-week follow-up (β 1.01, SD 0.40; <i>P</i> = 0.009).…”

Table3_Transcriptomics reveals a distinct metabolic profile in T cells from severe allergic asthmatic patients.xlsx by Carmela Pablo-Torres (10192451)

“…Compromised biological pathways in the severe phenotype were identified using significant transcripts. T cells' transcriptome of severe allergic asthmatic patients was distinct from that of mild and control subjects. …”