Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents by Marcian E. Van Dort (21374093)

“…Additionally, compound LP-65 demonstrated significant modulation of MEK and mTOR signaling activity in human glioma cells (D54) and human melanoma cells (A375), with a corresponding decrease in cellular proliferation and migration. …”

Study Data. by Jonathan S. Jahr (2709088)

“…It has also been hypothesized that the bradycardia and rare instances of cardiac arrest occurring after the use of sugammadex may be due to a transient decrease in circulating corticosteroids, causing a temporary ‘mini Addisonian crisis.’ …”

Risk of bias summary. by Duc Tran Quang (20564967)

“…The observed decrease in body weight could be partially attributed to factors influencing energy balance, as evidenced by the significantly lower mean calorie intake at the end of the intervention (1694.71 kcal/day, 95% CI: 1498.57–1890.85) compared to the baseline intake (2000.64 kcal/day, 95% CI: 1830–2172.98), despite the absence of intentional efforts to restrict energy intake by the participants. …”

Study outcomes. by Jonathan S. Jahr (2709088)

“…It has also been hypothesized that the bradycardia and rare instances of cardiac arrest occurring after the use of sugammadex may be due to a transient decrease in circulating corticosteroids, causing a temporary ‘mini Addisonian crisis.’ …”

Criteria for study selection. by Duc Tran Quang (20564967)

“…The observed decrease in body weight could be partially attributed to factors influencing energy balance, as evidenced by the significantly lower mean calorie intake at the end of the intervention (1694.71 kcal/day, 95% CI: 1498.57–1890.85) compared to the baseline intake (2000.64 kcal/day, 95% CI: 1830–2172.98), despite the absence of intentional efforts to restrict energy intake by the participants. …”

Number of visits per clinic type, 2013-2015. by Jacob Dreiher (14856863)

“…During PE, statistically significant longer waiting times were found for surgery (+1.0 day) and imaging (+1.1 days), while a 2.4 days decrease was noted in pediatrics, controlled for age, sex, ethnicity and the daily number of visits. …”

Patient characteristics. by Jonathan S. Jahr (2709088)

“…It has also been hypothesized that the bradycardia and rare instances of cardiac arrest occurring after the use of sugammadex may be due to a transient decrease in circulating corticosteroids, causing a temporary ‘mini Addisonian crisis.’ …”

Treatment with vitamin D3 reduced the viability of cancer cell lines: <i>1A & 1B.</i> by Vidya G. Bettada (22208808)

“…Mouse EAC cells showed a decrease in cell viability starting from 250 µM at 24h of treatment. …”

Feeding and starvation affect the proportion and cell cycle activity of Vasa2+/Piwi1+ cells. by Eudald Pascual-Carreras (12115380)

Vitamin D3, but not the Cisplatin, could moderately reduce STZ-induced hyperglycemia in mice (a) Schematic representation of experimental protocol followed in the study: After accl... by Vidya G. Bettada (22208808)

“…(c) Vitamin D3 and the positive control Cisplatin differently modulated FBG in hyperglycaemic mice: Intraperitoneal administration of vitamin D3 very minimally decreased FBG compared to vehicle control at the end of the study. …”

Changes in the active H3K27ac and repressive H3K27me3 histone marks among Vasa2+/Piwi1+ and all cells in fed, starved, and refed juvenile polyps. by Eudald Pascual-Carreras (12115380)

“…Between fed, T_5ds and T_20ds timepoints, MFI levels of H3K27ac progressively and significantly decreased while levels H3K27me3 (M) did not change significantly (N). …”

The effect of feeding and starvation on the proliferative competence and onset of cell cycle re-entry in all cell cycle-gated cells. by Eudald Pascual-Carreras (12115380)

The TOR inhibitors Rapamycin and AZD-8055 strongly reduce RPS6 phosphorylation and cell proliferation in Vasa2+/Piwi1+ cells. by Eudald Pascual-Carreras (12115380)

“…<i>n</i> = 2–4 biological replicates per condition, with 15 individuals per replicate. Significance levels for Student <i>t</i> test are indicated for adjusted <i>p</i> values: *<i>p</i> < 0.05, ***<i>p</i> < 0.001, ***<i>p</i> < 0.0001. d: day(s), n.s.: non-significant. …”

The effect of feeding and starvation on the proliferative competence and cell cycle re-entry dynamics of Vasa2+/Piwi1+ cells. by Eudald Pascual-Carreras (12115380)

Estimated results of the mediation effect. by Getachew Magnar Kitila (19935139)

“…The empirical findings show that greater trade openness is associated with significantly higher CO2 emission, additionally; it demonstrates that the influence is heterogeneous across different CO2 emission quantiles in African countries. …”

Panel unit root test result. by Getachew Magnar Kitila (19935139)

“…The empirical findings show that greater trade openness is associated with significantly higher CO2 emission, additionally; it demonstrates that the influence is heterogeneous across different CO2 emission quantiles in African countries. …”

Kernel density estimation for CO2. by Getachew Magnar Kitila (19935139)

“…The empirical findings show that greater trade openness is associated with significantly higher CO2 emission, additionally; it demonstrates that the influence is heterogeneous across different CO2 emission quantiles in African countries. …”

Change in panel quantile regression coefficients. by Getachew Magnar Kitila (19935139)

“…The empirical findings show that greater trade openness is associated with significantly higher CO2 emission, additionally; it demonstrates that the influence is heterogeneous across different CO2 emission quantiles in African countries. …”

Definitions of variables and measurements. by Getachew Magnar Kitila (19935139)

“…The empirical findings show that greater trade openness is associated with significantly higher CO2 emission, additionally; it demonstrates that the influence is heterogeneous across different CO2 emission quantiles in African countries. …”

Regression estimates: Double threshold model. by Getachew Magnar Kitila (19935139)

“…The empirical findings show that greater trade openness is associated with significantly higher CO2 emission, additionally; it demonstrates that the influence is heterogeneous across different CO2 emission quantiles in African countries. …”