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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
Published 2015“…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …”
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Effect of Crude Oil Products on the Geotechnical Properties of Sandy Soil
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Symptoms of depression and anxiety in anorexia nervosa
Published 2014“…Increase in the TRP/LNAA ratio was correlated with a decrease in depressive symptoms. …”
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
Published 2017“…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …”
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
Published 2020“…However, only in lower dose of sumac were significant decreases in the expression of oncogenic miR210 and increase of tumor-suppressive miR145 (miR21, miR22, and miR155 were not changed) observed. …”
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The impact of maternal care on child development
Published 2019“…Results show that treated children enjoy an increase of 3.6 h per week in the time they spend with their mothers, mainly due to a decrease in the time spent in non-institutional care. …”
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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis
Published 2018“…Only Cisplatin treatment caused a significant decrease in body weight and increase in serum ALT. …”
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Proteome analysis of Candida albicans cell wall mutants. (c2011)
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Sleeping habits during COVID-19 induced confinement: A study from Jordan
Published 2021“…Majority of the participants (53–59%) reported an increase in most of the sleep parameters except a decrease (49.1%) in daytime sleep. …”