The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) حسب Varghese P. Inchakalody (14557382)

"…Bisulfite-sequencing demonstrated 45.6% demethylation efficiency at the NY-ESO-1 gene promoter region and RT-qPCR analysis confirmed the significant induction of NY-ESO-1 at mRNA level (128-fold increase, *p < 0.050). …"

miRNA-dependent regulation of STIM1 expression in breast cancer حسب Rashmi P. Kulkarni (18618634)

"…<p dir="ltr">Store-operated Ca²⁺ entry (SOCE) has been shown to be important for breast cancer metastasis in xenograft mouse models. …"

β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo حسب Daaboul, Hamid E.

"…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …"
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Comparative Effect of Sodium Butyrate and Sodium Propionate on Ovarian Cancer Migration, Invasion, and Epithelial-To-Mesenchymal Transition حسب Sleem, Reem

"…Finally, our results revealed a significant decrease in the ratios of P-ERK/ERK and P-MEK/MEK following treatment. …"
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Qatar’s immigrants at higher risk of diabetes حسب Nature Research (16552612)

"…Because T2D is often associated with obesity, one might predict that the Arab participants, who had, on average, markedly higher body mass index (BMI) and waist circumference measures than the others, would exhibit high levels of glycated haemoglobin. The results, however, suggest that Qatar’s immigrant population has a significantly increased risk of having undiagnosed T2D, and that glycated haemoglobin levels could be a useful diagnostic tool for early detection of the disease. …"

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma حسب Peter Kubatka (11008854)

"…When compared to control specimens, evaluation of epigenetic alterations in rat tumor cells in vivo showed significant dose-dependent decrease in lysine methylation status of H3K4m3 and H3K9m3 and dose-dependent increase in lysine acetylation in H4K16ac levels (H4K20m3 was not changed) in treated groups. …"

The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis حسب Daaboul, Hamid E.

"…It also significantly decreased the levels of pro-caspase-3, p53, Bcl-2, p-Erk/Erk and p-Akt/Akt and increased p21 and Bax proteins. …"
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Endocrine contribution to the sexual dysfunction in patients with advanced chronic kidney disease and the role of hyperprolactinemia حسب Haitham Elbardisi (14058048)

"…Patients treated with cabergoline (<i>n</i> = 26) showed a significant increase in LH levels (<i>p</i> = .003) and a significant decrease in prolactin levels (<i>p</i> = .003). …"

Effect of acute and chronic grapefruit, orange and pineaple juice consumption upon blood lipoprotein synthesis and metabolism in the rat. (c2004) حسب Abou-Khalil, Jamil

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Myeloid Cells in Circulation and Tumor Microenvironment of Colorectal Cancer Patients with Early and Advanced Disease Stages حسب Salman M. Toor (8854751)

"…Lastly, we found that levels of GMCs decreased, while IMCs increased in the TME with tumor budding. …"

Dietary Curcumin Nanoparticles Improve Growth Performance, Oxidative Status and Immune Response of European Seabass (<i>Dicentrarchus Labrax</i>) حسب Albandari Bin-Ammar (16381128)

"…A noticeable decrease (P<0.05) in malondialdehyde (MDA) and considerable upregulation of hepatic insulin-like growth factor 1 (IGF1) and interleukin-1beta (IL-1β) mRNA levels were found in CURNPs-supplemented fish in a dose-dependent manner. …"

Psychological inoculation against problematic social media use among adolescents: An experimental study حسب Sameha Alshakhsi (17032311)

"…Results indicated a significant decrease in PSMU levels following active inoculation, particularly in withdrawal, persistence, displacement, and deception symptoms. …"

Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults حسب Khaddaj, Rashel

"…Furthermore, the change between both groups was significantly different (-7.61 ±4.03 in the Vitamin D group, -3.50±1.54 in the control group; p=<0.001) Conclusion: The present study shows thata 50.000 IU/week dose of vitamin D supplementation for 3 months was enough to increase vitamin D levels beyond sufficient and decrease depression symptoms in Saudi Arabian Adults. …"
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Shared Clean Mobility Operations for First-Mile and Last-Mile Public Transit Connections: A Case Study of Doha, Qatar حسب Afnan Fayez Eliyan (19517221)

"…Results indicate that public transit ridership can increase up to 17%. Moreover, adding the carpooling option can significantly decrease the number of relocations operations at a minimal impact on the commuters’ trip performance.…"

Fourier-Transform Infrared Imaging Spectroscopy and Laser Ablation -ICPMS New Vistas for Biochemical Analyses of Ischemic Stroke in Rat Brain حسب Mohamed H. M. Ali (5768066)

"…Also at this locus, there was a significant increase in aggregated protein as detected by high-levels Aβ1-42. …"

Risk Factors for Post-Cesarean, Surgical Site Infections in a Multi-Ethnic Population of Qatar حسب Sufia Athar (14777830)

"…Multiple drug-resistant organisms were isolated in 17.83% of cases.</p><h3>Conclusion</h3><p dir="ltr">This study provides baseline levels for SSI after CD across several different patient subgroups. …"

Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis حسب Evdokia Varamenti (8154642)

"…From those articles, 27 were included in the quantitative analysis (meta-analysis) as their results could be converted into common units.</p><h3>Results</h3><p dir="ltr">Following a short training session or performance test, an extremely large increase in protein carbonyls (PC) (ES 4.164; 95% CI 1.716 to 6.613;Z= 3.333,<i>p</i>= 0.001), a large increase in thiobarbituric acid reactive substances (TBARS) (ES 1.317; 95% CI 0.522 to 2.112;<i>Z</i>= 3.247,<i>p</i>= 0.001), a large decrease in glutathione (GSH) (ES − 1.701; 95% CI − 2.698 to − 0.705;<i>Z</i>= − 3.347,<i>p</i>= 0.001), and a moderate increase of total antioxidant capacity (TAC) level (ES 1.057; 95% CI − 0.044 to 2.158;<i>Z</i>= 1.882, <i>p</i>= 0.060) were observed. …"

PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications حسب Pramod Darvin (153341)

"…The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …"

Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an In vivo mouse model حسب Kobeissy, Firas

"…Finally, reactive oxygen species (ROS) production was significantly accentuated in S+MI group concomitant with a significant increase in NOX-4 protein levels. …"
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Chemical characterization and cytotoxic activity evaluation of Lebanese propolis حسب Faour, Wissam H.

"…Toxicity started early after 24 h of incubation and remained till 72 h. Interestingly, the decrease in cell viability was accompanied by a significant increase in p53 protein expression levels and PARP cleavage. …"
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