DataSheet1_Lipocalin-2 drives neuropsychiatric and cutaneous disease in MRL/lpr mice.docx by Sayra J. Garcia (19748644)

“…</p>Results<p>In this study, we found that LCN2 deficiency significantly attenuates neuropsychiatric and cutaneous disease in MRL/lpr lupus prone mice, likely by decreasing local infiltration of immune cells into the brain and skin and reducing astrocyte activation in the hippocampus. …”

Table 1_Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.xlsx by Asma Bibi (12057986)

“…The KEGG enrichment analysis of serum and brain samples showed that amino acid metabolism pathways, such as tryptophan metabolism, threonine metabolism, serotonergic synapsis, methionine metabolism, and neuroactive ligand-receptor interaction, were significantly decreased in antibiotic-treated mice. Our study demonstrates that long-term antibiotic use induces gut dysbiosis and alters metabolic responses, leading to the dysregulation of brain signaling molecules and anxiety-like behavior. …”

Supplementary file 1_Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.docx by Xuan Zhao (356028)

“…The data analysis results indicated that the disease activity index (DAI), histopathological score (HS), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and myeloperoxidase (MPO) activity in the IBD animal models significantly decreased following intervention with oxymatrine. …”

Table 1_Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis.docx by Shuting Li (6552)

“…In a murine model of peritoneal fibrosis induced by intraperitoneal injection of 4.25% PD fluid, SAL treatment significantly mitigated peritoneal fibrosis, as evidenced by reduced collagen deposition, decreased protein expression of α-smooth muscle actin and Collagen I, and a thinner peritoneum. …”

Image 2_13C-CO2 pulse labelling evaluation of water deficit on leaf carbon dynamics and whole plant allocation in fruiting coffee.png by Janice Nakamya (21898532)

“…These were analysed to assess ¹³C enrichment in relation to carbon assimilation and leaf carbon changes over time. Water deficit significantly decreased carbon assimilation by 20-52% compared to well-watered plants, especially in young leaves (p< 0.05). …”

Supplementary file 6_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Prognostic value of miR-378c in hepatocellular carcinoma and its regulatory effect on tumor progression by Yuanjie Bao (21075400)

“…</p> <p>Serum miR-378c expression is decreased in HCC patients and strongly connected with poor prognosis. …”

Supplementary file 2_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.jpeg by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Data Sheet 1_SNP rs10748643 determines CD39 expression in T and NK cells through altering NFIC binding affinity rather than interfering with RNA splicing.docx by Chenxin Gan (22750214)

“…Using Cleavage Under Targets and Tagmentation (CUT&Tag) technology, we found that the binding affinity of NFIC decreases when SNP mutates from A to G, causing the reduced inhibition of NFIC on CD39 expression in T cells. …”

Candidate genes by Genome-wide CRISPR Screen. by Mingyi Xu (5575871)

“…In this work, we found that RNA2.7 deletion significantly decreased the viability of HCMV-infected cells, while treatment with ferroptosis inhibitor Fer-1 rescued the infection-induced cell death, demonstrating an anti-ferroptosis role of RNA2.7. …”

Presentation 1_CRIF1 gene therapy ameliorates inflammatory bowel disease by suppressing TH17 cells and fibrosis through mitochondrial function regulation.zip by Jin-Sil Park (294905)

“…Patients with ulcerative colitis exhibited decreased CRIF1 levels with dysfunctional mitochondria in inflamed colonic tissue. …”

Supplementary file 1_Bioactive fraction isolated from Curcuma angustifolia rhizome exerts anti-diabetic effects in vitro, in silico and in vivo by regulating AMPK/PKA signaling pat... by P. Kavya (21356483)

“…After 28 days of intervention, the lower and higher doses of the bioactive fraction (100 and 200 mg/kg BW) substantially decreased fasting blood glucose levels and ameliorated hyperglycemia, glucose intolerance, insulin resistance, and hyperlipidemia. …”

Image_1_Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse.jpg by Katrina S. Hofstetter (17545425)

“…EdU incorporation is significantly downregulated. In addition, mitotic retinal progenitor cells mislocalize deeper, basal regions, likely contributing to decreased proliferation. …”

Supplementary file 5_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Table 1_Co-frequency or contrary? The effects of Qiwei Baizhu Powder and its bioactive compounds on mucosa-associated microbiota of mice with antibiotic-associated diarrhea.docx by Zeli Zhang (3422570)

“…The results showed that QWBZP-TG significantly altered the diversity, structure, and abundance of MAM in the AAD mice. …”

Table 1_LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis.docx by Yihan Liu (2258221)

“…</p>Results<p>OIP5-AS1 expression was significantly decreased in LUAD tissues and associated with poor survival. …”

Presentation 1_Ischemia-reperfusion injury with a model of porcine whole-blood ex-vivo lung perfusion.pptx by Jean-Baptiste Menager (22163560)

“…Interleukin-6 and −8 levels after 6 h were significantly higher in the long CIT group (mean differences, 1.1 pg/ml; 95% CI, 0.39–1.8; P = 0.003; and 29.31 pg/ml; 95%CI, 16.00–42.61; P < 0.001; respectively). …”

Image 2_Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.tif by Asma Bibi (12057986)

“…The KEGG enrichment analysis of serum and brain samples showed that amino acid metabolism pathways, such as tryptophan metabolism, threonine metabolism, serotonergic synapsis, methionine metabolism, and neuroactive ligand-receptor interaction, were significantly decreased in antibiotic-treated mice. Our study demonstrates that long-term antibiotic use induces gut dysbiosis and alters metabolic responses, leading to the dysregulation of brain signaling molecules and anxiety-like behavior. …”

Data Sheet 1_Land use change has profoundly altered the process of bacterial community assembly in the northeastern black soil zone.pdf by Ning Sun (162468)

“…Co-occurrence network analysis showed that reclamation reduced interspecies interactions and significantly decreased network complexity, connectivity, and cohesion (P < 0.05). …”

The effect of Tawny crazy ants on the abundance of aboveground insect abundance in Texas by Ryan Reihart (9174179)

“…Additionally, areas were <i>N. fulva </i>were abundant had tended to have fewer grasshoppers from the Melanoplinae subfamily, which are likely decreasing in abundance due to direct predation and fleeing <i>N. fulva</i> abundant areas. …”