CK8 knockdown and ROCK1 inhibitor abolished rTsSPc-reduced TJs expression in Caco-2 monolayers by IFA. by Wen Wen Zheng (17721404)

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PAS staining of intestinal sections from <i>T. spiralis</i>-infected mice pretreated with DAS and Y27632. by Wen Wen Zheng (17721404)

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qPCR and Western blotting of CK8 knockdown blocking the rTsSPc-activated pathway and -reduced TJs expression. by Wen Wen Zheng (17721404)

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IFA, GST pull-down and Co-IP assay of specific binding between rTsSPc and CK8. by Wen Wen Zheng (17721404)

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Transcription and expression levels of CK8 in Caco-2 cells after CK8 gene was knocked down. by Wen Wen Zheng (17721404)

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qPCR and Western blotting of activation of CK8 receptor and RhoA/ROCK1 pathway proteins in Caco-2 cells treated with rTsSPc and IIL ES antigens. by Wen Wen Zheng (17721404)

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CK8 knockdown and ROCK1 inhibitor suppressed rTsSPc-induced disruption of the Caco-2 monolayer and blocked rTsSPc-promoted IIL invasion. by Wen Wen Zheng (17721404)

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Intraperitoneal injection protocol for inhibitors (A), inhibitors DAS and Y27632 reduced intestinal permeability (B) and intestinal adult worm burden (C) of infected mice. by Wen Wen Zheng (17721404)

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HE staining showed that DAS and Y27632 alleviated intestinal inflammation in <i>T. spiralis</i>-infected mice. by Wen Wen Zheng (17721404)

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The ROCK1 pathway inhibitor Y27632 prevented rTsSPc from activating the ROCK1 pathway and reducing TJs expression. by Wen Wen Zheng (17721404)

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qPCR (A-D) and ELISA (E-H) detection of inflammatory cytokines in intestine of <i>T. spiralis</i>-infected mice. by Wen Wen Zheng (17721404)

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Image 4_Pediatric kidney transplant recipients are at an increased risk for dysbiosis.jpeg by Gizem Yılmaz (20641691)

“…In addition, KTx recipients with a history of frequent urinary tract infections, diarrhea and reduced GFR showed significant increases in bacterial abundance (p < 0.05 for all).…”

Image 1_Pediatric kidney transplant recipients are at an increased risk for dysbiosis.jpeg by Gizem Yılmaz (20641691)

“…In addition, KTx recipients with a history of frequent urinary tract infections, diarrhea and reduced GFR showed significant increases in bacterial abundance (p < 0.05 for all).…”

Image 3_Pediatric kidney transplant recipients are at an increased risk for dysbiosis.jpeg by Gizem Yılmaz (20641691)

“…In addition, KTx recipients with a history of frequent urinary tract infections, diarrhea and reduced GFR showed significant increases in bacterial abundance (p < 0.05 for all).…”

Image 2_Pediatric kidney transplant recipients are at an increased risk for dysbiosis.jpeg by Gizem Yılmaz (20641691)

“…In addition, KTx recipients with a history of frequent urinary tract infections, diarrhea and reduced GFR showed significant increases in bacterial abundance (p < 0.05 for all).…”

Presentation 1_Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence.pptx by Juan Chen (61123)

“…</p>Conclusion<p>This study integrated meta-analysis, murine model validation, and single-cell transcriptomic profiling to demonstrate a significant reduction of BDNF in CKD. Furthermore, renal BDNF expression decreased locally, predominantly originating from proximal tubule cells, macrophages, and podocytes, possibly epigenetically inhibited by the upregulation of lnc RNA Bdnf-as.…”

Table_1_FMT intervention decreases urine 5-HIAA levels: a randomized double-blind controlled study.DOCX by Lihong Wang (14991)

“…However, in the placebo group, GSRS, CARS, and SRS scores showed no significant changes, while ABC scores decreased from 72 to 58.75 (p = 0.034). …”

HIV-1 Env generalized neutralization sensitivity impacts differentially on the potency of broadly neutralizing antibodies (bnAbs). by Caio Foulkes (20592250)

Definitions of variables. by Qi Zhang (28502)

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Theoretical model diagram. by Qi Zhang (28502)

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