Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone حسب Ilhame Diboun (3522413)

"…Additionally, methylation profiles in 11 regions showed Bonferroni-significant association with disease severity including six islands (located in VCL, TBX5, CASZ1, ULBP2, NUDT15 and SQSTM1), two gene bodies (CXCR6 and DENND1A), and 3 promoter regions (RPL27, LINC00301 and VPS29). …"

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease حسب Nour K. Majbour (8809316)

"…<h3>Background</h3><p dir="ltr">Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. …"

Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes حسب Tracy Augustine (14149932)

"…<p>The hygiene hypothesis has been popularized as an explanation for the rapid increase in allergic disease observed over the past 50 years. Subsequent epidemiological studies have described the protective effects that in utero and early life exposures to an environment high in microbial diversity have in conferring protective benefits against the development of allergic diseases. …"

Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases حسب Mazhar Pasha (11197767)

"…Thus, the aim of this review is to discuss the upstream regulators and the downstream effectors of Sestrins and to highlight the significance of Sestrin2 as a biomarker and a therapeutic target in diseases such as metabolic disorders, cardiovascular and neurodegenerative diseases, and cancer.…"

Machine Learning based Model Reveals the Metabolites Involved in Coronary Artery Disease حسب Fathima Lamya (22565261)

"…The results show that 173 metabolites ( P < .05) are significantly associated with CAD. Of these metabolites, the majority (95/173, 54.91%) were high in CAD patients, while 45.09% (78/173) were high in the control group. …"

Prevalence of non-communicable disease and the associated factors among healthcare workers in Qatar حسب Ayman Al-Dahshan (8962568)

"…<h3>Background</h3><p dir="ltr">Non-communicable diseases (NCDs) significantly impact global health and contribute to economic burdens and premature deaths, with healthcare workers (HCWs) being at high risk. …"

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation حسب Larissa Haertle (3864310)

"…Furthermore, T21 patients have a high risk of developing Alzheimer’s disease (AD) early in life, characterized by the presence of senile plaques of amyloid protein and neurofibrillary tangles, leading to neuronal loss and cognitive decline. …"

Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor حسب Mahmoud A. Alomari (14780446)

"…Subsequent ANCOVA revealed differences (p < 0.05) in TC, HDL, LDL, TC/LDL, and TriG/HDL but not in glucose, TriG, and TC/HDL among the patients with low-BDNF versus high-BDNF.</p><h3>Significance</h3><p dir="ltr">The results demonstrate a relationship of BDNF with lipid profile suggesting the importance of BDNF for lipid metabolism in PD.…"

Anti-amyloid monoclonal antibody therapies in Alzheimer’s disease – a scoping review حسب Shahd Abubaker Elamin (22569539)

"…<p dir="ltr">Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide, and with advancements in the medical field, Anti-amyloid monoclonal antibodies (AA mAbs) targeting amyloid-β have emerged as potential disease-modifying agents altering AD pathology. …"

Mulberry Leaf Disease Detection Using CNN-Based Smart Android Application حسب Abdus Salam (1918387)

"…However, mulberry trees are highly susceptible to diseases, spreading rapidly and causing significant losses. …"

Shear Strength Behavior of Tire Shred-Dune Sand Admixtures حسب Ahmad, Abrar

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Can the Salivary Microbiome Predict Cardiovascular Diseases? Lessons Learned From the Qatari Population حسب Selvasankar Murugesan (4376506)

"…This study aims to identify whether a predictive salivary microbiome signature is associated with a high risk of developing CVD in the Qatari population.…"

Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease حسب El Maarri, Osman

"…Additionally, high methylation levels at TNFRSCF10C were associated with positive perineural spread of tumor cells, while higher methylation levels of TNFRSF10C and ACIN1 were significantly associated with shorter survival. …"
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Trends of the Dementia Burden in South Asia: An Analysis of 2021 Global Burden of Disease Study حسب Shubham Chauhan (21334742)

"…While prevalence rates experienced a minor decline, Disability‐Adjusted Life Years (DALYs) rose from 272.02 to 308.27 per 100,000, reflecting an increasing burden of the disease. Notably, Nepal significantly reduced its incidence rates, while Pakistan saw an increase in mortality rates. …"

Endocrine contribution to the sexual dysfunction in patients with advanced chronic kidney disease and the role of hyperprolactinemia حسب Haitham Elbardisi (14058048)

"…Testosterone levels and the incidence of erectile dysfunction or premature ejaculation did not improve significantly. There is a high incidence of sexual dysfunction among patients. …"

The role of preoperative transfusion in sickle cell disease, a systematic review and meta-analysis حسب Yasamin Abdu (15899155)

"…Further high-quality studies are needed to refine recommendations.…"

Cutting‐edge technologies for detecting and controlling fish diseases: Current status, outlook, and challenges حسب Sk Injamamul Islam (14111241)

"…Early detection of disease is crucial for farmers as mortality rates can reach as high as 100% if left untreated. …"

National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050 حسب Marie, Ng

"…Without major reform, the forecasted trends will be devastating at the individual and population level, and the associated disease burden and economic costs will continue to escalate. …"
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Myeloid Cells in Circulation and Tumor Microenvironment of Colorectal Cancer Patients with Early and Advanced Disease Stages حسب Salman M. Toor (8854751)

"…Notably, patients with advanced disease stages showed significantly higher levels of GMCs compared to early stages in whole blood, but PBMCs and tumor-infiltrating myeloid cells did not show any significant differences. …"

Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019 حسب Razieh, Hassannejad

"…BackgroundThe burden of heart failure (HF) is high globally, but information on its burden in the Eastern Mediterranean Region (EMR) is limited. …"
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