Uncovering the mechanistic basis of <i>Rheum palmatum</i> L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular doc... by Wenjing He (4278625)

“…Molecular docking confirmed strong binding affinities of rhubarb’s core compounds with key targets such as TNF and IL6, supporting their therapeutic roles.</p> <p>Rhubarb significantly reduces renal impairment, fibrosis, inflammation, and apoptosis through the NF-κB pathway, supporting its traditional use and potential as an adjunct therapy for CKD.…”

Supplementary file 1_Dachaihu decoction ameliorates abnormal behavior by regulating gut microbiota in rats with propionic acid-induced autism.docx by Yangyang Zhang (608493)

“…Meanwhile, the small clinical trial revealed that DCHD significantly alleviated the core symptoms of ASD, with decreased ADOS-2 and ABC scale scores. …”

Data Sheet 1_Dachaihu decoction ameliorates abnormal behavior by regulating gut microbiota in rats with propionic acid-induced autism.zip by Yangyang Zhang (608493)

“…Meanwhile, the small clinical trial revealed that DCHD significantly alleviated the core symptoms of ASD, with decreased ADOS-2 and ABC scale scores. …”

Table 1_Altered brain functional network connectivity and topology in type 2 diabetes mellitus.doc by Weiwei Ni (9269921)

“…</p>Discussion<p>This study demonstrated significant abnormalities in connectivity and topology of large-scale brain functional networks in T2DM patients. …”

Data Sheet 1_Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease.pdf by Yan Wu (70890)

“…The apoptotic cell death marker cleaved caspase-3 immunoreactive (Caspase-3-IR) percentage in orexin-IR neurons was significantly higher in Tg-SwDI mice than in WT controls. …”

Semaglutide ameliorates diabetes-associated cognitive dysfunction in mouse model of type 2 diabetes by Yan Zhu (112437)

“…</p><p dir="ltr"><b>Results:</b> Semaglutide treatment significantly reduced blood glucose levels in diabetic mice. …”

DataSheet1_Identification of common signature genes and pathways underlying the pathogenesis association between nonalcoholic fatty liver disease and heart failure.docx by Gerui Li (15648920)

“…Experimental validation indicated unbalanced macrophage polarization in HF and NAFLD mouse models, and the expression of CD163 and CCR1 were significantly down-regulated.</p>Conclusion<p>This study identified M2 polarization impairment characterized by decreased expression of CD163 and CCR1 as a common pathogenic pathway in NAFLD and HF. …”

Data Sheet 1_Plausibility of super high-flux dialyzer reuse in maintenance hemodialysis.pdf by Piyapun Prapunwatana (22474063)

“…Dialysate albumin loss decreased significantly from 1.01 g during the 1st use to 0.19 g during the 2nd and 0.06 g during the 5th use (p-value < 0.001). …”

Image 1_Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress.jpeg by Na Wang (193263)

“…It also increased mitochondrial function and ATP levels, reduced intracellular reactive oxygen species, and elevated intracellular GSH levels in both oocytes and embryos. Moreover, FMN significantly decreased autophagy and apoptosis levels in blastocyst cells, potentially via regulation of the Nrf2/Keap1 pathway. …”

Data Sheet 1_Diethyl butylmalonate attenuates cognitive deficits and depression in 5×FAD mice.docx by Lai Yuan (20136422)

“…</p>Results<p>Multiple behavioral tests showed that DBM effectively mitigated cognitive deficit and depression in 5×FAD mice. Moreover, DBM significantly attenuated synaptic ultrastructure and neurite impairment in the hippocampus of 5×FAD mice, paralleled by the improvement of the deficits of PSD95 and BDNF proteins. …”

Data Sheet 1_Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress.zip by Na Wang (193263)

“…It also increased mitochondrial function and ATP levels, reduced intracellular reactive oxygen species, and elevated intracellular GSH levels in both oocytes and embryos. Moreover, FMN significantly decreased autophagy and apoptosis levels in blastocyst cells, potentially via regulation of the Nrf2/Keap1 pathway. …”

Table 8_Case Report: fNIRS-guided rehabilitation in refractory post-traumatic dysphagia.xlsx by Xiaohan Wang (691917)

“…After 42 days, swallowing function improved significantly, with the Functional Oral Intake Scale (FOIS) rising from level I to VI and the Penetration-Aspiration Scale (PAS) decreasing from 8 to 2.…”

Table 4_Case Report: fNIRS-guided rehabilitation in refractory post-traumatic dysphagia.docx by Xiaohan Wang (691917)

“…After 42 days, swallowing function improved significantly, with the Functional Oral Intake Scale (FOIS) rising from level I to VI and the Penetration-Aspiration Scale (PAS) decreasing from 8 to 2.…”

Table 7_Case Report: fNIRS-guided rehabilitation in refractory post-traumatic dysphagia.docx by Xiaohan Wang (691917)

“…After 42 days, swallowing function improved significantly, with the Functional Oral Intake Scale (FOIS) rising from level I to VI and the Penetration-Aspiration Scale (PAS) decreasing from 8 to 2.…”

Table 1_Case Report: fNIRS-guided rehabilitation in refractory post-traumatic dysphagia.docx by Xiaohan Wang (691917)

“…After 42 days, swallowing function improved significantly, with the Functional Oral Intake Scale (FOIS) rising from level I to VI and the Penetration-Aspiration Scale (PAS) decreasing from 8 to 2.…”

Table 6_Case Report: fNIRS-guided rehabilitation in refractory post-traumatic dysphagia.docx by Xiaohan Wang (691917)

“…After 42 days, swallowing function improved significantly, with the Functional Oral Intake Scale (FOIS) rising from level I to VI and the Penetration-Aspiration Scale (PAS) decreasing from 8 to 2.…”

Table 5_Case Report: fNIRS-guided rehabilitation in refractory post-traumatic dysphagia.docx by Xiaohan Wang (691917)

“…After 42 days, swallowing function improved significantly, with the Functional Oral Intake Scale (FOIS) rising from level I to VI and the Penetration-Aspiration Scale (PAS) decreasing from 8 to 2.…”

Data Sheet 1_Iron improves the antiviral activity of NK cells.docx by Simone Schimmer (85325)

“…Interestingly, although iron supplementation decreased the NK cell’s cytokine production, it significantly improved NK cell degranulation and the expression of cytotoxicity-associated proteins. …”

Table 2_Case Report: fNIRS-guided rehabilitation in refractory post-traumatic dysphagia.docx by Xiaohan Wang (691917)

“…After 42 days, swallowing function improved significantly, with the Functional Oral Intake Scale (FOIS) rising from level I to VI and the Penetration-Aspiration Scale (PAS) decreasing from 8 to 2.…”

Table 3_Case Report: fNIRS-guided rehabilitation in refractory post-traumatic dysphagia.docx by Xiaohan Wang (691917)

“…After 42 days, swallowing function improved significantly, with the Functional Oral Intake Scale (FOIS) rising from level I to VI and the Penetration-Aspiration Scale (PAS) decreasing from 8 to 2.…”