Supplementary Material for: Fibrillin-1 deficiency perturbs aortic cholinergic relaxation and adrenergic contraction in a mouse model of early onset progressively severe Marfan syn... by Cantalupo A. (20574239)

“…Results: Isometric force measurements of aortic rings from 16-day-old male Fbn1mgR/mgR mice revealed a significant reduction in acetylcholine (ACh)-induced relaxation and increased phenylephrine (PE)-promoted contractility, associated with abnormally low eNOSSer1177 phosphorylation, decreased NO production and augmented superoxide levels. …”

Data Sheet 1_Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model.pdf by Zhuo-ma Dawa (20632718)

“…After PAB treatment, the levels of CD4⁺ T lymphocytes increased and the levels of CD8⁺ T lymphocytes decreased in the host tissue surrounding the metacestodes and the spleen. …”

Table 2_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Table 4_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Table 1_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Table 3_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Data Sheet 1_China’s readiness for transitioning to a low-carbon economy: mitigant and catalyst factors for a geopolitical conflict.zip by Yan Chen (4308)

“…Furthermore, LCED can ameliorate GPR by decreasing dependence on energy imports, promoting international cooperation, and encouraging scientific innovation. …”

Data Sheet 2_The relict plant Tetraena mongolica plantations increase the nutrition and microbial diversity in desert soil.docx by Yanan Quan (19732382)

Data Sheet 1_The relict plant Tetraena mongolica plantations increase the nutrition and microbial diversity in desert soil.docx by Yanan Quan (19732382)

Data Sheet 1_Effect of Medicaid accountable care on preventable emergency department and hospital admissions: rural-urban heterogeneity.pdf by Jangho Yoon (13258614)

“…</p>Results<p>The CCO model was associated with reductions of 25 all-cause ED visits and 22 preventable ED visits per 1,000 persons per month during the first three years. Significant decreases in all-cause and preventable ED visits were observed across different levels of rurality. …”

<b>Identification and Validation of LOXL2 as a Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma through Multi-Omics and Functional Analysis</b> by Ge Qiao (21802511)

“…</p><p dir="ltr"><b>Key findings:</b> LOXL2 has been identified as a significant prognostic biomarker in LUAD, with high expression levels correlating with poor overall survival. …”

Table 1_Global burden trends of tension-type headache, 1990–2021: socio-demographic patterns, age-period-cohort effects, and frontier analysis from the GBD 2021 study.docx by Can Wang (157994)

“…Contrasting trends emerged: globally and in High and High-middle SDI regions rates decreased, while Middle SDI regions showed significant increases (prevalence: +5.83%). …”

Table 2_Global burden trends of tension-type headache, 1990–2021: socio-demographic patterns, age-period-cohort effects, and frontier analysis from the GBD 2021 study.docx by Can Wang (157994)

“…Contrasting trends emerged: globally and in High and High-middle SDI regions rates decreased, while Middle SDI regions showed significant increases (prevalence: +5.83%). …”

Data Sheet 1_Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection.docx by Xinyi Shi (3133611)

“…The serum metabolic profile of IAV patients was significantly changed, and the purine metabolism was destroyed. …”

Image 2_Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection.jpeg by Xinyi Shi (3133611)

“…The serum metabolic profile of IAV patients was significantly changed, and the purine metabolism was destroyed. …”

Image 5_Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection.jpeg by Xinyi Shi (3133611)

“…The serum metabolic profile of IAV patients was significantly changed, and the purine metabolism was destroyed. …”

Image 6_Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection.jpeg by Xinyi Shi (3133611)

“…The serum metabolic profile of IAV patients was significantly changed, and the purine metabolism was destroyed. …”

Image 4_Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection.jpeg by Xinyi Shi (3133611)

“…The serum metabolic profile of IAV patients was significantly changed, and the purine metabolism was destroyed. …”

Image 3_Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection.jpeg by Xinyi Shi (3133611)

“…The serum metabolic profile of IAV patients was significantly changed, and the purine metabolism was destroyed. …”

Image 1_Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection.jpeg by Xinyi Shi (3133611)

“…The serum metabolic profile of IAV patients was significantly changed, and the purine metabolism was destroyed. …”