Gastric microbiome composition accompanied with the <i>Helicobacter pylori</i> related DNA methylation anomaly by Takuya Shijimaya (16928363)

“…Multivariate analysis demonstrated older age (t = 3.46, <i>p</i> = 0.0007), <i>H. pylori</i> infection (t = 9.99, <i>p</i> < 0.0001) and lower bacterial alfa diversity (Shannon index: t = -2.34, <i>p</i> = 0.02) were significantly associated with CGI hypermethylation. In genus or family levels, increased abundance of <i>Helicobacter</i> was associated with hyper CGI methylation with strongest correlation, while decreased abundance of four bacteria (<i>Intrasporangiaceae family, Macellibacteroides</i>, <i>Peptostreptococcus</i> and <i>Dietziaceae family</i>) was also associated with hyper CGI methylation. …”

Table 3_Tackling global inequalities in maternal hypertensive disorders: trends and the impact of public health emergencies, 1990–2021.csv by Siying Wei (5990276)

“…Disease burden generally decreased with higher SDI levels. Decomposition analysis suggested that demographic factors increased the burden, while epidemiology mitigated it. …”

Table2_Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models.DOCX... by Hongbo Cheng (2848235)

“…</p>Results<p>The expression of S1pr2 significantly increased following TBI in mice. Pharmacological inhibition of S1pr2 alleviated secondary injury with reduced lesion volume, ROS generation, cerebral oedema, neurological deficits, and neuronal apoptosis; BBB disruption was also mitigated, accompanied by reduced degradation of tight junction proteins and decreased induction of matrix metalloproteinases-9 (MMP-9) post-TBI. …”

Image3_Protective effects of YCHD on the autoimmune hepatitis mice model induced by Ad-CYP2D6 through modulating the Th1/Treg ratio and intestinal flora.tif by Jiawen Wu (63886)

“…The changes in the species and abundance of intestinal flora and intestinal flora metabolites were analyzed via 16S rRNA gene sequencing and gas chromatography-mass spectrometry (GC/MS) to reveal the protective mechanism of YCHD on liver injury.</p>Result<p>YCHD decreased the transaminase activity (AST and ALT), the content of autoantibodies (LC-1 and LKM-1), and the serum TNF-α, IL-12, and IL-17 levels in AIH mice. …”

Data Sheet 1_The Syringe Pump Gas Distribution (SPGD) system: a simple and low-cost method for simulating NH3/15NH3 deposition.docx by Chunze Wu (14348715)

“…The cost, complexity, and risk associated with simulating NH₃ deposition can be significantly decreased by utilizing the SPGD system. …”

Table3_Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models.DOCX... by Hongbo Cheng (2848235)

“…</p>Results<p>The expression of S1pr2 significantly increased following TBI in mice. Pharmacological inhibition of S1pr2 alleviated secondary injury with reduced lesion volume, ROS generation, cerebral oedema, neurological deficits, and neuronal apoptosis; BBB disruption was also mitigated, accompanied by reduced degradation of tight junction proteins and decreased induction of matrix metalloproteinases-9 (MMP-9) post-TBI. …”

Image 3_Prediction of major adverse cardiovascular events following ST-segment elevation myocardial infarction using cardiac obesity marker—epicardial adipose tissue mass index: a... by Zeyan Liu (3748747)

“…Background<p>Although reperfusion therapy has led to improvements in the acute phase of ST-segment elevation myocardial infarction (STEMI), the incidence of major adverse cardiovascular events (MACE) following STEMI has not significantly decreased. The accumulation of epicardial adipose tissue (EAT) may be associated with poorer STEMI prognosis and could serve as a potential prognostic marker. …”

Table1_Identification and expression profiling of neuropeptides and neuropeptide receptor genes in a natural enemy, Coccinella septempunctata.DOCX by ShunDa Han (19822464)

“…During diapause induction, the mRNA abundance of AKH was notably higher on the 10th day compared to non-diapause females, but decreased by the 20th day. In contrast, GPHA showed lower expression levels on the 5th day of diapause induction compared to non-diapause females, but increased significantly by the 15th and 20th days. …”

Table 4_Tackling global inequalities in maternal hypertensive disorders: trends and the impact of public health emergencies, 1990–2021.xlsx by Siying Wei (5990276)

“…Disease burden generally decreased with higher SDI levels. Decomposition analysis suggested that demographic factors increased the burden, while epidemiology mitigated it. …”

Image 1_Multi-omics analysis reveals indicator features of microbe-host interactions during Candida albicans colonization and subsequent infection.tif by Huan Zhang (220065)

“…The indicator features of decreased Dubosiella abundance and SCFA levels, coupled with increased Mucispirillum and D-erythro-imidazolylglycerol phosphate, are likely linked to the development of translocated invasive infection in hosts colonized rectally by C. albicans with lower serum protein levels.…”

Figure 6 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia by Sydney A. Skupa (18597728)

“…Asterisks denote the significance between antibiotic-receiving or water-receiving mice over time (*, <i>P</i> < 0.05). …”

IntegraBrain: A multi-modal neural interface for the detection and suppression of focal epilepsy by Spencer Moore (8440863)

“…Long-term implantation of these devices would risk inducing significant compression injury and localised glial scaring over time.…”

Supplementary file 1_Bioinformatics analysis combined with experimental validation reveals the novel mechanisms of multi-targets of dapagliflozin attenuating diabetic liver injury.... by Pengyu Wang (6680312)

“…</p>Results<p>Dapagliflozin alleviated diabetic liver injury by decreasing lipid deposition, oxidative stress levels, the inflammatary and apoptosis-related proteins and mRNA levels, while it also reducing blood glucose. …”

Table1_Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and coloca... by Jingshuang Song (11340138)

“…Decreased levels of CASP8, DDX58, CPNE1, ULK3, PARK7, and BTN2A1, as well as increased levels of TNFRSF9, TNXB, DNPH1, and TLR1, were linked to an elevated risk of breast cancer. …”

DataSheet1_Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and co... by Jingshuang Song (11340138)

“…Decreased levels of CASP8, DDX58, CPNE1, ULK3, PARK7, and BTN2A1, as well as increased levels of TNFRSF9, TNXB, DNPH1, and TLR1, were linked to an elevated risk of breast cancer. …”

DataSheet2_Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and co... by Jingshuang Song (11340138)

“…Decreased levels of CASP8, DDX58, CPNE1, ULK3, PARK7, and BTN2A1, as well as increased levels of TNFRSF9, TNXB, DNPH1, and TLR1, were linked to an elevated risk of breast cancer. …”

Divergent gene expression in <i>D. sechellia.</i> by Daehan Lee (5043377)

“…Cell types with significant differential expression are shown on the x-axis. …”

Table 1_Inner engineering is associated with perceived improvements in relationship quality, interpersonal connections, and interpersonal compassion.docx by Nashaw Jafari (20467640)

“…Linear mixed-effects models were used to analyze the survey data, with p-values of < 0.05 considered statistically significant.</p>Results<p>From the baseline to the 6-week follow-up after the program, the participants reported experiencing more positive qualities (p < 0.001, ηp2 = 0.12) and fewer negative qualities (p = 0.001, ηp2 = 0.08) in their relationships, increased interpersonal mindfulness (p < 0.001, ηp2 = 0.30), decreased stress levels (p < 0.001, ηp2 = 0.27), enhanced compassion for others (p < 0.001, ηp2 = 0.17), and overall personal wellbeing (p < 0.001, ηp2 = 0.25).…”

Determinants of lipid lowering therapy intensification in very high risk patients with dyslipidaemia eligible for PCSK9 monoclonal antibodies: 1-year outcomes of the PERI-DYS study by Klaus G. Parhofer (12280424)

“…</p> <p>Among 1565 patients, LDL-C levels decreased from 91.0 mg/dL at baseline to 73.5 mg/dL at 6 months and 71.5 mg/dL at 12 months. …”

Evaluating the effectiveness of safety countermeasures at highway–railway grade crossing based on a machine learning framework by Mohammadali Zayandehroodi (19746176)

“…Then, the DCLA method achieved 4 distinct clusters optimized by high similarity within each cluster and significant independence among clusters. The effectiveness of countermeasures was computed in terms of CMF and SE. …”