Assessing the Causal Role of Walking Pace and Hand Grip Strength with Chronic Obstructive Pulmonary Disease Hospital: A Mendelian Randomization Study by Lu Wang (45927)

“…</p> <p>Our research shows a link between slower walking pace and higher COPD hospitalization risk, as well as decreased lung function (PEF, FEV1, FVC). We also found a significant correlation between weaker hand grip and reduced lung function, especially FVC. …”

DataSheet1_The β2-adrenergic biased agonist nebivolol inhibits the development of Th17 and the response of memory Th17 cells in an NF-κB-dependent manner.docx by Mehri Hajiaghayi (19822665)

“…</p>Results<p>Nebivolol treatment decreased IL-17A and IFN-γ secretion by activated memory Th cells and elevated IL-4 levels. …”

Heart looping variations in <i>Notch3</i> and <i>Nodal</i> compound mutants. by Tobias Holm Bønnelykke (20968460)

“…(<b>H</b>) Quantification of the looping direction frequency in homozygote <i>Nodal</i> mutants with decreased <i>Notch3</i> (right bar), which, in contrast to <i>Nodal</i> mutants with normal <i>Notch3</i> levels (middle bar), differs from a randomized looping direction (dotted line). …”

<i>mig-21</i> sensitizes adult DTCs to polarizing signals. by Xin Li (51274)

“…However, migration cessation is not rescued; a significant increase in “overmigration” defects is observed between marked control (n=4/57) and <i>mig-21(u787)</i> on <i>vab-3</i> RNAi (n=17/65), p < 0.05. …”

USUV replicates in STAT1-sufficient peripheral tissues leading to spleen and liver pathology. by Amy N. Nelson (21763146)

“…USUV RNA was quantified in the (A) liver, (B) spleen, (C) kidney, (D) lung, and (E) brain of Vav-Cre/<i>Stat1</i>^fl/fl, <i>Stat1</i>^-/-, and <i>Stat1</i>^fl/fl mice by qPCR. Significant levels of USUV RNA were detected in the liver, spleen, kidney, and lung of Vav-Cre/<i>Stat1</i>^fl/fl and <i>Stat1</i>^-/- mice. …”

Excel raw data. by Michael Getie (12400923)

“…The effectiveness of currently available antimicrobial is decreasing due to the increasing prevalence of resistant strains among bacterial isolates. …”

Zika virus replicates efficiently in the zebrafish model and induces morphological defects. by Aïssatou Aïcha Sow (20371233)

“…. **** P ≤ 0.0001; ns = not significant; one-way ANOVA. (F-G) Total ZIKV RNA (F) and ZIKV negative strand (-) RNA (G) levels in whole larvae pools (6–15 larvae) at 1, 2 and 3 dpf were determined using ddPCR. …”

Data collected from pregnant women for the analysis of placental anemia, placental malaria, Cytokines and birth anthropometric indices by Bamgboye Morakinyo Afolabi (16838970)

“…However, it has been shown that while peripheral parasitemia may remain below the levels of microscopic detection, these parasites are detectable in the placenta [2]. …”

Discriminating wake vs. NREM sleep from individual spike train measures. by Fabiano Baroni (234173)

“…MSTMs are ordered according to decreasing decoding accuracy. Gray dotted lines indicate significance thresholds, with darker shades of gray indicating more stringent significance levels. …”

PRMT5 isoforms during zebrafish developmental stages by Zain Zakaria (20354028)

“…Remarkably, despite the lack of any significant change in prmt5 mRNA levels between 18 and 72 hpf, Prmt5 protein expression showed dynamic changes at 18 and 72 hpf, which were accompanied by a change in mobility of Prmt5 protein at 72 hpf compared to other developmental stages.…”

Analysis of connexin 43 expression in mice inoculated intravenously with EVs (green) or ICs (blue). by Alberto Cornet-Gomez (10676133)

“…<p>Confocal microscopy revealed decreased connexin 43 synthesis in mice injected with EVs and ICs <b>(A)</b>. …”

CDCP1 regulates CDA and hENT1 expression through c-Src/PKCδ signaling pathway. by Kun-Lin Hsieh (11401919)

“…<p>(A, B) Quantitative PCR analysis of CDA and hENT1 mRNA expression levels in T24, T24-CD, and T24-CDKO cells. T24-CD cells exhibited increased CDA and decreased hENT1 expression, whereas T24-CDKO cells showed the opposite trend. …”

Experiment 3 –trial E. by Ottavia Benedicenti (9100619)

“…Violin plots show Cq median (solid line). Statistical significance levels were calculated with the GraphPad Prism v9.3.1 (* = p ≤ 0.05; n = 3).…”

supplementary figure: Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma by Takuto Itano (16830105)

“…(middle): Effects of MYLK4 knockdown in AD-RD cells. siMYLK4 treatment reduced self-renewal capacity and decreased SALL2 and pT43-CDKAL1 protein levels. (right): Clonogenic potential (n = 3) of AD-RD cells treated with 1 nM actinomycin D and 1 µM osimertinib. …”

Experiment 2, trial D. by Ottavia Benedicenti (9100619)

“…Violin plots show Cq median (solid line). Statistical significance levels were calculated only between different lysis buffers within the same filter type with the GraphPad Prism v9.3.1 (* = p ≤ 0.05; ** = p ≤ 0.01; **** = p ≤ 0.0001; n = 3).…”

Image 1_Atractylenolide-I prevents abdominal aortic aneurysm formation through inhibiting inflammation.tif by Shuxiao Chen (7339340)

“…</p>Results<p>ATL-I inhibited the dilatation of the abdominal aorta and decreased the incidence of AAA. ATL-I alleviated the infiltration of macrophages in the adventitia and reduced the levels of proinflammatory factor IL-1β and IL-6 in the aorta and circulatory system, while increasing the expression of anti-inflammatory factor IL-10. …”

Table1_Effect of inflammatory cytokines and plasma metabolome on OSA: a bidirectional two- sample Mendelian randomization study and mediation analysis.pdf by Xin Sun (127355)

“…Furthermore, we found that the increased risk of OSA could be attributed to reduced levels of X-11849 and X-24978 (decreases of 7.1% and 8.4%, respectively). …”

Data_Sheet_1_The functions and factors governing fungal communities and diversity in agricultural waters: insights into the ecosystem services aquatic mycobiota provide.pdf by Phillip Pham (407350)

“…</p>Discussion<p>Water physicochemical properties, including stream fungicide levels, explained a small proportion of the variation in mycobiota communities, underscoring the significance of unmeasured factors, alongside stochastic community assembly processes. …”

Data Sheet 1_Landscape analysis of m6A modification regulators reveals LRPPRC as a key modulator in tubule cells for DKD: a multi-omics study.docx by Li Jiang (120930)

“…Background<p>Diabetic Kidney Disease (DKD) is a serious complication of diabetes, imposing a substantial medical burden. The significance of N6-methyladenosine (m6A) modification in the pathogenesis of DKD has become increasingly prominent.…”

LRIG1 and CDK6 expression in the lateral ventricular wall cells by Hyung-song Nam (8914220)

“…Although the <i>Cdk6</i> mRNA decreases significantly in the neuroblasts, the DCX+ neuroblasts still show a lot of td-sfGFP immunoreactivity.…”