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    An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals by Dominique Detaille (3768979)

    Published 2019
    “…<div><p>Findings</p><p>Here, we demonstrate that OP2113 (5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione, CAS 532-11-6), synthesized and used as a drug since 1696, does not act as an unspecific antioxidant molecule (i.e., as a radical scavenger) but unexpectedly decreases mitochondrial reactive oxygen species (ROS/H<sub>2</sub>O<sub>2</sub>) production by acting as a specific inhibitor of ROS production at the I<sub>Q</sub> site of complex I of the mitochondrial respiratory chain. …”
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