Data Sheet 1_ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway.docx حسب Xiaofei Huang (2262337)

"…Moreover, it suppressed conventional CD4⁺CD25^- T cell proliferation in vitro in the absence of antigen-presenting cells (APCs), with an increase in IL-10 and decrease in IFN-γ production. On the other hand, it did not significantly alter DC maturation after allotransplantation.…"

Data Sheet 1_Analysis of lymphocytic leukemia trends among gender, race, age, and regional groups in the U.S. between 1999-2022: a CDC-WONDER database study.docx حسب Shannon Blee (15251230)

"…</p>Conclusion<p>LL overall mortality decreased from 1999–2022 but varied significantly amongst demographic groups. …"

Data Sheet 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.xlsx حسب Demos Kynigopoulos (12420457)

"…Increasing evidence implicates systemic metabolic dysregulation in AD pathogenesis, yet it remains unclear whether modulation of peripheral lipid and glucose metabolism can alter disease progression.</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …"

Supplementary file 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.docx حسب Demos Kynigopoulos (12420457)

"…Increasing evidence implicates systemic metabolic dysregulation in AD pathogenesis, yet it remains unclear whether modulation of peripheral lipid and glucose metabolism can alter disease progression.</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …"

<b>Supporting data for ''The pathogenicity and pathogenic mechanism of SARS-CoV-2 Omicron''</b> حسب Bingjie Hu (10835565)

"…Further mechanistic investigations reveal that the Omicron subvariant is ineffective in using TMPRSS2 compared with ancestral SARS-CoV-2 (HKU-001a) and previous variants, which may contribute to its decreased replication in Calu3 and Caco2 cells. In K18-hACE2 transgenic mice, the replication capacity of the Omicron subvariant is significantly attenuated in both the upper and lower respiratory tracts of virus-infected animals when compared to that of the ancestral strain and Delta (B.1.617.2) variant, correlating with substantially ameliorated lung pathology. …"

DataSheet1_Chronic exposure to inhaled vaporized cannabis high in Δ9-THC suppresses Adderall-induced brain activity.zip حسب Jack M. Ognibene (19830132)

"…The data were registered to a mouse 3D MRI atlas with 134 brain regions providing site-specific increases and decreases in global brain activity.</p>Results<p>Mice exposed to cannabis when compared to placebo showed a decrease in brain activation to Adderall. …"

Table 1_Effects of the efficacy of the Yi Shen Tiao Gan formula on aromatase inhibitor associated musculoskeletal syndrome: a randomized controlled trial.xlsx حسب Yan Zhang (8098)

"…Before and after treatment, the total WOMAC score of both groups of patients significantly decreased (p < 0.05), with the pain subscale score of the treatment group being significantly lower than that of the control group (p < 0.05). …"

Accommodating talker variability in noise (Zhang & Peng, 2025) حسب Kaile Zhang (21763791)

"…However, high noise levels significantly hinder this ability. BN presents greater challenges than BMN at lower SNRs, likely due to increased informational masking. …"

Image 1_Behavioral benefits of GSK-3β inhibition and state-dependent microtubule signatures in the Fmr1-KO mouse.jpeg حسب John Kealy (17399515)

"…SB216763 normalized social discrimination in 3-CST, while AF3581 only produced a non-significant positive trend. Neither compound altered α-tubulin PTMs. …"

Data Sheet 1_Palmitoylethanolamide causes dose-dependent changes in brain function and the lipidome.docx حسب Shreyas Balaji (20344923)

"…While levels of PEA in the CNS were significantly higher after 30 mg/kg treatment, levels of the endocannabinoid, Anandamide, and at least 20 additional endolipids, were significantly lower across the CNS. …"

Comparison of Mean Absolute Error (MAE) in Millimeters as a Function of Kernel Size. حسب Liu Liu (512237)

"…The Full Model generally maintains a lower MAE, suggesting higher accuracy than the Reduced Depth model. …"

Image1_ASC speck serum concentrations, a component of sterile cellular inflammation, are associated with individual cardiopulmonary capacity.JPEG حسب Alexander Kogel (13296595)

"…Athletes with an increase in ASC speck concentrations in response to CPET had a lower peak oxygen pulse compared to those with a decrease (17.1 ± 4.2 vs. 19.8 ± 4.1, p < 0.05).…"

Table 1_Association between life’s crucial 9 and sarcopenia: estimated glucose disposal rate as a key mediator.doc حسب Xialian Tang (22319332)

"…However, after adjusting for all covariates including BMI, this association became non-significant (OR: 0.994, p = 0.282). Compared to the lowest tertile, participants in the highest tertiles of LC9 and eGDR had significantly lower odds of SP, with reductions of 83.4% (p < 0.001) and 86.0% (p < 0.001), respectively. …"

Table 1_MIKC-type MADS-box transcription factor OsMADS31 positively regulates salinity tolerance in rice.xlsx حسب Xiaolin Yin (359202)

"…At the three-leaf stage, knockout mutants showed significantly lower survival rates following salt treatment and subsequent recovery. …"

Data Sheet 1_MIKC-type MADS-box transcription factor OsMADS31 positively regulates salinity tolerance in rice.pdf حسب Xiaolin Yin (359202)

"…At the three-leaf stage, knockout mutants showed significantly lower survival rates following salt treatment and subsequent recovery. …"

Table 2_Oxphos targeting of MYCN-amplified neuroblastoma.xlsx حسب Soraya Epp (22489120)

"…Similarly to DPI, MitoQ appears to have a greater effect on cells with higher MYCN levels. Furthermore, low nanomolar concentrations of MitoQ significantly decrease MYCN protein expression and induce differentiation of MNA cells. …"

Table 1_Oxphos targeting of MYCN-amplified neuroblastoma.xlsx حسب Soraya Epp (22489120)

"…Similarly to DPI, MitoQ appears to have a greater effect on cells with higher MYCN levels. Furthermore, low nanomolar concentrations of MitoQ significantly decrease MYCN protein expression and induce differentiation of MNA cells. …"

Data Sheet 1_Oxphos targeting of MYCN-amplified neuroblastoma.pdf حسب Soraya Epp (22489120)

"…Similarly to DPI, MitoQ appears to have a greater effect on cells with higher MYCN levels. Furthermore, low nanomolar concentrations of MitoQ significantly decrease MYCN protein expression and induce differentiation of MNA cells. …"

Table 2_Associations between physical fitness components and metabolic syndrome in middle-aged adults: a cross-sectional study using relative strength indicators and ROC analysis.d... حسب Zhanfei Zheng (22629227)

"…</p>Results<p>The participants with MetS showed significantly lower relative grip strength, relative lower-limb strength, and VO₂max than their non-MetS counterparts. …"

Table 1_Associations between physical fitness components and metabolic syndrome in middle-aged adults: a cross-sectional study using relative strength indicators and ROC analysis.d... حسب Zhanfei Zheng (22629227)

"…</p>Results<p>The participants with MetS showed significantly lower relative grip strength, relative lower-limb strength, and VO₂max than their non-MetS counterparts. …"