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C1 alone does not evoke NO release, an increase in cell activity or release of pro-inflammatory cytokines.
Published 2023“…As shown in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0278325#pone.0278325.g001" target="_blank">Fig 1</a></b>, LPS stimulation induced a significant increase in NO release (p<0.0001). Treatment with C1 or DMSO did not show any significant difference compared to untreated microglia (in white). …”
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Inclusion of TPP side chains result in decreased melanoma cell mitochondria membrane potential, oxygen consumption, and increased DHE oxidation.
Published 2020“…(B) Oxygen consumption rates were measured using a Seahorse Bioscience XF96 extracellular flux analyzer in A375 melanoma cells treated with or without 1.0 μM 12-TPP (N = 4). At the 25 min mark, 1.0 μM 12-TPP was added to treatment A375 cells followed by the sequential addition of 2.5 μM oligomycin at the 60 min mark, 0.3 μM oligomycin at the 90 min mark, and 5.0 μM rotenone/antimycin A at the 120 min mark. …”
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AZ10606120 treatment does not significantly increase apoptosis mediated cell death.
Published 2025Subjects: