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significantly impairs » significantly impacts (Expand Search), significantly impact (Expand Search), significantly improves (Expand Search)
significantly mean » significantly less (Expand Search), significantly mediate (Expand Search), significantly impact (Expand Search)
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4041
<b>Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional </b><b><i>WFS1</i></b><b> varian...
Published 2025“…Pancreatic β cells obtained from patient-derived induced Pluripotent Stem Cells (iPSCs) carrying this <i>WFS1 </i>variant exhibited reduced insulin processing and impaired secretory granule maturation, as evidenced by proinsulin accumulation and decreased prohormone convertase PC1/3. …”
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4042
Image 1_Elevated miR-17-5p facilitates mycobacterial immune evasion by targeting MAP3K2 in macrophages.jpeg
Published 2025“…Increased miR-17-5p suppressed MAP3K2 expression and attenuated MAPK signaling, reducing phosphorylation of ERK, JNK, and p38. This resulted in decreased production of inflammatory mediators (TNF-α, IL-6, IL-1β), reduced iNOS and ROS levels, and impaired bacterial clearance.…”
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4043
Supplementary file 1_ZnO nanoparticles induce acute arrhythmia and heart failure in mice by disturbing cardiac ion channels.pdf
Published 2025“…Mechanistically, exposure to ZnO NPs did not significantly affect the IK1, but it markedly decreased I<sub>Na</sub> and I<sub>Ca−L</sub> currents, resulting in a reduced amplitude and shortened duration of the action potential in cardiomyocytes. …”
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4044
Image3_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.TIF
Published 2025“…</p>Results<p>The results showed that C16 significantly improved the clinical score and cortical somatosensory/motor evoked potential. …”
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4045
Image7_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG
Published 2025“…</p>Results<p>The results showed that C16 significantly improved the clinical score and cortical somatosensory/motor evoked potential. …”
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4046
Image9_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG
Published 2025“…</p>Results<p>The results showed that C16 significantly improved the clinical score and cortical somatosensory/motor evoked potential. …”
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4047
Table 1_RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking.xlsx
Published 2025“…ARL5B expression was significantly downregulated in treated Y79 and Weri-RB1 cells. …”
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4048
Mass spectrometry of Pparα-En4 pulldown proteins.
Published 2025“…Functional assays demonstrated that targeted repression of Pparα-En4 region significantly decreased <i><i>Ppar</i>α</i> expression and impaired brown adipocyte differentiation and thermogenesis. …”
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4049
Data Sheet 1_Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11.docx
Published 2025“…Bryostatin-1 upregulated TCF-1 and decreased TOX expression. These changes were confirmed through RNA-seq analysis. …”
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4050
Image 3_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4051
Table 2_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.docx
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4052
Image 2_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4053
Image 11_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4054
Image 7_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4055
Image 8_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4056
Image 6_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4057
Image 4_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4058
Image 9_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4059
Image 12_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”
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4060
Image 1_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.jpeg
Published 2025“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”