FSA inhibits MaAKT1 channels through <i>S</i>-glutathionylation. by Jun Zhang (48506)

“…Representative whole-cell current traces and summary of the preventive effect of GSH (2 mM) in the pipette on FSA-induced MaAKT1 inhibition (n = 3). Ns, not significant compared with the control group. Data in (<b>B</b>) to (<b>D</b>) are shown as means ± SE and compared using Student’s t-test (<b>C</b>) or paired Student’s t-test (<b>B</b> and <b>D</b>). …”

supplementary figure: Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma by Takuto Itano (16830105)

“…The RT‒PCR data are presented as the means ± SDs (n = 3). Statistical significance: ns, p ≥ 0.05. …”

Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies by Shazia Sofi (17764488)

“…Chemoresistance in cancer can arise from a variety of molecular mechanisms, including active drug expulsion (drug efflux), decreased drug uptake, enhanced DNA repair mechanisms, the ability of cancer cells to evade programmed cell death (apoptosis), the diversity in the population of cancer cells within a tumor (tumor heterogeneity), and significant alterations in the tumor microenvironment (TME), where interactions between cancer cells, cancer-associated fibroblasts, immune cells, and the extracellular matrix contribute to a supportive environment that allows tumors to survive treatment and escape therapy. …”

Table 1_Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.docx by Juan Liu (6492)

“…</p>Methods<p>In this study, we evaluated the synergism of tigecycline combining with other antibiotics as a means of overcoming the tet(X)-mediated resistance in Acinetobacter spp. …”

Zika virus replicates efficiently in the zebrafish model and induces morphological defects. by Aïssatou Aïcha Sow (20371233)

“…<i>N</i> = 3). Data are shown as means ± SEM. **** P ≤ 0.0001; ns = not significant; one-way ANOVA. …”

Behavior is best fit by models with independent attributes. by Aster Q. Perkins (22008260)

“…Bars show across-session means, circles show values from individual sessions. …”

Table 3_Do the diagnosis-related group payment reforms have a negative impact?—an empirical study from Western China.docx by Jia-Yi Wang (490704)

“…In the treatment group hospitals, the primary beneficiaries of the reform were urban employees’ basic medical insurance patients, whose costs decreased by 4.9% (p < 0.01), with a non-significant effect on out-of-pocket payment patients and free medical care patients; the hospitals in the treatment group tended to reduce the use of Chinese medicine unique diagnostic and therapeutic means and increase the proportion of western medicine treatments under the pressure of the supremacy of costs.…”

Table 2_Do the diagnosis-related group payment reforms have a negative impact?—an empirical study from Western China.xlsx by Jia-Yi Wang (490704)

“…In the treatment group hospitals, the primary beneficiaries of the reform were urban employees’ basic medical insurance patients, whose costs decreased by 4.9% (p < 0.01), with a non-significant effect on out-of-pocket payment patients and free medical care patients; the hospitals in the treatment group tended to reduce the use of Chinese medicine unique diagnostic and therapeutic means and increase the proportion of western medicine treatments under the pressure of the supremacy of costs.…”

Table 1_Do the diagnosis-related group payment reforms have a negative impact?—an empirical study from Western China.xlsx by Jia-Yi Wang (490704)

“…In the treatment group hospitals, the primary beneficiaries of the reform were urban employees’ basic medical insurance patients, whose costs decreased by 4.9% (p < 0.01), with a non-significant effect on out-of-pocket payment patients and free medical care patients; the hospitals in the treatment group tended to reduce the use of Chinese medicine unique diagnostic and therapeutic means and increase the proportion of western medicine treatments under the pressure of the supremacy of costs.…”

Supporting data for “Androgen receptor modulates chemotherapy response in breast cancer” by Chanping You (9067448)

“…For palbociclib, a CDK4/6 inhibitor, AR activation induced RB1 polyubiquitination and degradation, diminishing RB1 levels—a key downstream target of CDK4/6—and thus impairing palbociclib efficacy. Chromatin immunoprecipitation (ChIP) sequencing identified 1,209 AR-regulated genes, with gene ontology (GO) analysis highlighting significant enrichment of ubiquitin-related genes. qPCR validation pinpointed TRIM37, an AR-regulated E3 ligase, as a mediator of RB1 degradation. …”

OVD-induced transient OHT in mice leads to RGC loss and astrocyte reactivity. by Weiran Huang (8934899)

“…<p>(A) OVD injections led to IOP increase, with values presented as means ± SD. IOP decreased 6 hours post-injection and by day 1 had returned to near baseline levels. …”

Heart looping variations in <i>Notch3</i> and <i>Nodal</i> compound mutants. by Tobias Holm Bønnelykke (20968460)

“…</i> Filled and empty arrowheads point to curved and straight outflow tract, respectively. Means and standard deviations are shown. L, Left; LV, left ventricle; n.s., non-significant; R, Right; RV, right ventricle. …”

Table 1_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx by Ning An (618997)

“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”

Table 4_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx by Ning An (618997)

“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”

Image 1_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.tif by Ning An (618997)

“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”

Table 3_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx by Ning An (618997)

“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”

Table 2_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx by Ning An (618997)

“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”

<i>mig-21</i> sensitizes adult DTCs to polarizing signals. by Xin Li (51274)

“…A robust “extra turn” defect rate of control on <i>vab-3</i> RNAi (n=38/57) decreases with <i>mig-21(u787)</i> on <i>vab-3</i> RNAi (n=24/65), p < 0.01. …”