No significant differences in the numbers of eggs between Mst1^+/+ and Mst1^ΔM/ΔM mice. by Jianyang Li (461703)

FBP primarily decreases the protein level of HMGB1 by promoting its lysosomal degradation upon viral infection. by Penghui Hu (695020)

SHAP dependence plots with interaction coloring. by Wentao Yang (205781)

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Screening process diagram. by Wentao Yang (205781)

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SHAP waterfall plot. by Wentao Yang (205781)

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SHAP decision plot. by Wentao Yang (205781)

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LASSO regression visualization plot. by Wentao Yang (205781)

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SHAP dependence plots. by Wentao Yang (205781)

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Tertile stratified subgroup analysis. by Wentao Yang (205781)

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Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

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Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

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Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

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Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

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Data for Fig 6D. by Xiaohua Zhang (350570)

“…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (¹³²DVAADAAAEAAAAE¹⁴⁵) mutated strain (PRV-UL4^mut) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”

Data for Fig 5D. by Xiaohua Zhang (350570)

“…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (¹³²DVAADAAAEAAAAE¹⁴⁵) mutated strain (PRV-UL4^mut) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”

Data for Figs 8A–8H, 9A–9K, 10A–10I. by Xiaohua Zhang (350570)

“…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (¹³²DVAADAAAEAAAAE¹⁴⁵) mutated strain (PRV-UL4^mut) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”

Schematic illustration of the proposed role of XO and NOX4 in the heart of PG-LPS-treated mice. by Akinaka Morii (12709672)

Unraveling the Mechanism of 1‑Deoxynojirimycin (DNJ) Accumulation: The Role of SWEET3 in Mulberry Chloroplasts by Zhen Yang (107412)

“…Transient overexpression or RNA interference of <i>SWEET3</i> in mulberry leaves significantly increased or decreased DNJ levels, respectively, while stable overexpression in hairy roots enhanced DNJ accumulation. …”

Evogliptin attenuates the pyroptotic cell death of VSMCs during CER treatment by decreasing the pyroptotic-associated genes and GSDM-D cleavage efficiency <i>in-vitro.</i> by Razia Rashid Rahil (22772495)

Disruption of the <i>pcnB</i> gene encoding poly(A) polymerase PAP I decreases pYV PCN as well as T3SS expression and activity. by Katherine Schubert (5452712)