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Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
Published 2020“…Mechanical stretch significantly increased p-ERK1/2 after 10 minutes, whereas APN significantly reduced stretch-induced ERK1/2 phosphorylation. …”
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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
Published 2023“…The use of a CRISPR-dCas9 UNISAM and KRAB system could increase or decrease SLFN11 expression significantly (up to fivefold), stably and specifically in BT-549 and T47D cancer cell lines. …”
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Phosphorus supplementation recovers the blunted diet-induced thermogenesis of overweight and obese adults
Published 2016“…Overweight/obese subjects had a blunted DIT with placebo, while P supplementation induced a 23% increase in their DIT area under the curve (p < 0.05), which was associated with a significant increase in carbohydrate oxidation. …”
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Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats
Published 2023“…Histopathological studies of the cardiac tissue showed isoprenaline-induced injury that was significantly attenuated by the extract.…”
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DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
Published 2000“…However, when ultrasound was applied, a rapid and significant increase in DNA damage was observed (P=0.0001). …”
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Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice
Published 2010“…In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. …”
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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis
Published 2018“…HC treatment decreased significantly cell survival (IC50 = 7 and IC90 = 40 μg/ml) and increased significantly cells undergoing late apoptosis and necrosis. …”
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IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
Published 2002“…We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels. Aim: To determine whether ceramide induces apoptosis in IEC. …”
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Sleeping habits during COVID-19 induced confinement: A study from Jordan
Published 2021“…<p dir="ltr">Sleep can significantly modulate the immune response to infectious agents. …”
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Efficacy of Lebanese Cannabis Oil Extract in the Treatment of Folic Acid-Induced Renal Fibrosis in Rats
Published 2023“…In addition, a significant decrease in serum creatinine was observed in groups receiving cannabis extract at the doses of 5 and 10 mg/kg. …”
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Kefir induces cell-cycle arrest and apoptosis in HTLV-1-negative malignant T-lymphocytes
Published 2011“…Upon kefir treatment, a marked increase in cell-cycle distribution was noted in the preG1 phase of CEM and Jurkat cells, indicating the proapoptotic effect of kefir, which was further confirmed by Cell Death Detection ELISA. …”
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Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity
Published 2025“…<h3 dir="ltr">Purpose</h3><p dir="ltr">The recreational use of synthetic cannabinoids (SCs) by adolescents and adults has markedly increased in recent years. Previous studies demonstrated that exposure to SCs is associated with multiple adverse health effects. …”
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Therapeutic Effect of Lebanese Cannabis Oil Extract in the Management of Sodium Orthovanadate-Induced Nephrotoxicity in Rats
Published 2023“…All doses of Cannabis oil caused significant decrease in serum urea, as well as in serum creatinine at a dose of 20mg/Kg. …”
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Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death
Published 2023“…Overall, these findings provide evidence that arginine deprivation induced by [HuArgI(Co)-PEG5000] leads to increased ROS production, lipid peroxidation, and dysregulation of iron metabolism and antioxidant pathways, all of which are hallmarks for the occurrence of ferroptosis in AML cells following arginine deprivation. …”
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Prevention of carcinogen-induced mouse skin papilloma by Daucus carota (wild carrot) aqueous extract
Published 2011“…Intraperitoneal treatment decreased hyperplasia and dermal infiltration with an increase in the level of hyperkeratosis. …”
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
Published 2024“…Our results revealed that the administration of AB-FUBINACA induced a significant impairment in recognition memory associated with histopathological changes in the hippocampus. …”
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
Published 2024“…Our results revealed that the administration of AB-FUBINACA induced a significant impairment in recognition memory associated with histopathological changes in the hippocampus. …”
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Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice
Published 2020“…Results showed that Cd induced a significant increase in liver injury biomarkers coupled with enhanced lipid peroxidation (MDA) and significant depletion of antioxidants (CAT and SOD). …”
