A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase by Ahmed S. Ibrahim (10049522)

“…In the presence of arachidonic acid, additional eicosanoids generated by 12/15-LOX, including 12- and 11-HETEs, were significantly increased. Fluorescein angiography and retinal albumin leakage showed a significant decrease in retinal hyperpermeability in streptozotocin-induced diabetic mice lacking 12/15-LOX compared with diabetic WT mice. …”

Trends of the Dementia Burden in South Asia: An Analysis of 2021 Global Burden of Disease Study by Shubham Chauhan (21334742)

“…</p><h3>Results</h3><p dir="ltr">A slight decrease in incidence rates from 80.57 to 79 per 100,000 was observed, alongside a significant increase in mortality rates from 14.11 to 17.2 per 100,000. …”

Preparation of Mesoporous/Microporous MnCo₂O₄ and Nanocubic MnCr₂O₄ Using a Single Step Solution Combustion Synthesis for Bifunction Oxy... by Anchu Ashok (14152020)

“…Chronoamperometric (CA) runs for 24 h shows excellent stability of MnCo₂O₄ without any significant decrease in the current or potential value in ORR and OER. …”

Effect of partial medial meniscectomy on anterior tibial translation in stable knees by Yammine, Kaissar

“…Our values might reflect a temporarily increase of anterior laxity under specific conditions but whether a significant laxity remains in some knees, such changes may lead to higher cartilage loading and early osteoarthritis.…”
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Effect of COVID-19 on the Generation of Waste in Marrakech, Morocco by Abdellah Ouigmane (18460623)

“…In addition, changes in living conditions can induce significant variation in the quantitative and qualitative characteristics of waste.…”

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors by Noura Aldous (15429873)

“…Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …”

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... by Masri, Oussama Samer

“…Conclusion A decrease in reflectivity of the choriocapillaris and Sattler’s in amblyopic compared to healthy eyes, and a decrease in reflectivity of the RNFL in the amblyopic compared to fellow eyes, indicate that the pathophysiology is partly peripheral and might be bilateral.…”
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The anti-neoplastic activity of novel platinum II and IV complexes against A549 lung cancer cells by Al Sayegh, Rouba

“…Western blots experiments were also carried out to observe the effect of the drugs on key apoptotic proteins. Data revealed a significant drop in procaspase 3 and a significant increase in Bax/Bcl2 ratio, Cytochrome c, Parp and procaspase 8. …”
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Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway by Hodroj, Mohammad Hassan

“…Background Topotecan (TP) is an anticancer drug acting as topoisomerase I inhibitor that is used in the treatment of many types of cancers including leukemia, but it has significant side effects. Andrographolide, a compound extracted from Andrographis paniculata, was recently proven to inhibit the growth of cancer cells and can induce apoptosis. …”
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Effect of methanolic extract of Quercus infectoria bark on blood lipid profile, glycemia, inflammation, platelet aggregation, ulcer and bacterial activity. (c2005) by Khouzami, Lara

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Preparation of albumin-targeted liposomes and the study of their release characteristics using ultrasound by Turki, Renad

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Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone by Abdoulaye Diane (14152749)

“…Treatment of C2C12 cells with 0.3 mM of ALA triggers a significant increase in the expression of DNAJB3 mRNA and protein. …”

Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat. by Daher, Costantine F.

“…In the chronicstudy, only grapefruit significantly decreased plasma and VLDL TAG concentrations and relative VLDL particlesize with respect to other groups. …”
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Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers by Yadav, Santosh K.

“…Significantly lower NP test scores was observed in HIC than those of HUC. …”
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Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer by Adviti Naik (673163)

“…Following <i>LDHC</i> knockdown, we observed an increase in the secretion of tumor-derived pro-inflammatory cytokines (IFN-γ, GM-CSF, MCP-1, CXCL1), a decrease in the soluble levels of tumor-derived immunosuppressive factors (IL-6, Gal-9) and reduced tumor cell surface PD-L1 expression. …”

Effects of organic enrichment on macrofauna community structure: an experimental approach by Rodrigo Riera (10476249)

“…AMBI and M-AMBI indices were calculated and a decrease of ecological status was observed in treatment 3x.…”

The Effect of the Variation of the Modulus of Subgrade Reaction on the Design of Large Shallow Foundations by Al Kaaby Al Zoaby, Hassan

“…With the use of variable coefficient across the mat foundation, a significant decrease in the steel reinforcement is witnessed and an optimized/ more adapted steel distribution is observed.…”
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Tragopogon porrifolius water extract. (c2010) by Saab, Lea Elias

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Formation of Trihalomethanes during Seawater Chlorination by Ahmed Abdel-Wahab (1748986)

“…Rapid decrease of UV absorbance at 254 nm was also observed during seawater chlorination which is indicative of natural organic matter degradation into small organic molecules including THMs and other by-products. …”

Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis by Fateen Ata (12217764)

“…In a multivariate logistic regression model, massive PE features significantly increased the odds of death (OR: 29.3, CI: 4.86–181.81, p < 0.001), whereas, treatment with anticoagulation (AC) alone (OR: 0.1, CI: 0.027–0.356, p < 0.001), TT (OR: 0.065, CI: 0.019–0.26, p < 0.001), surgical thrombectomy (ST) (OR: 0.047, CI: (0.010–0.23), p < 0.001), or percutaneous thrombectomy (PT) (OR: 0.12, CI: 0.020–0.84, p = 0.032) significantly decreased odds of death.…”