A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells حسب Abou-Ghazal, Mohamed K.

"…Although WP1066 did not induce immunological memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (TGF-β, RANTES, MCP-1, VEGF), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …"
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A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... حسب Abou-Ghazal, Mohamed

"…Although WP1066 did not induce immunologic memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (transforming growth factor-β, RANTES, MCP-1, vascular endothelial growth factor), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …"
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Qatar’s immigrants at higher risk of diabetes حسب Nature Research (16552612)

"…These differences have been observed before, but are usually attributed to differences in access to, and the quality of, medical care. …"

High flow nasal oxygen (HFNO) in the treatment of COVID-19 infection of adult patients from – An emergency perspective: A systematic review and meta-analysis حسب Nabil, Shallik

"…HFNO was associated with a significant decrease in mortality and intubation rates (0.28 (95% CI; 0.19, 0.39) and 0.28 (95% CI; 0.18, 0.41), respectively). …"
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Dietary Curcumin Nanoparticles Improve Growth Performance, Oxidative Status and Immune Response of European Seabass (<i>Dicentrarchus Labrax</i>) حسب Albandari Bin-Ammar (16381128)

"…The down regulation of hepatic heat shock protein 70 (HSP70) was observed in CURNPs150. Intestinal and hepatic architectures were improved significantly by CURNPs. …"

Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles حسب El Maarri, Osman

"…Our results show that no significant association with age was observed. However, the previously reported increase of LINE-1 methylation in males was reconfirmed. …"
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Effect of Acute and Chronic Moderate Red or White Wine Consumption on Fasted and Postprandial Lipemia in the Rat حسب Daher, Costantine F.

"…Phospholipid and cholesterol contents of CM, but not very-low-density lipoprotein (VLDL), were increased, indicating enhanced liver bile secretion; however, a significant increase in plasma VLDL concentration was observed. …"
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Symptoms of depression and anxiety in anorexia nervosa حسب Mattar, Lama

"…We speculate that enhanced TRP availability during re-feeding, as a result of the increase in the TRP/LNAA ratio, could restore serotonin neurotransmission and lead to a decrease in depressive symptoms. The association between serotonin and anxiety and depressive symptoms would be consistent with numerous observations indicating abnormal functioning of the serotoninergic system in AN…"
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Formation of Bromate in Pet Bottle Water حسب Sharif, Haifa

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Total hip arthroplasty: Evolution of the use of dual mobility cups in Lebanon حسب Assi, Chahine

"…Recurrent dislocation, being a major reason for revision total hip arthroplasty (THA), was found to decrease significantly using dual mobility cup (DMC) compared to standard cups (SC), and that in both primary and revision THA. …"
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Walking around the preferred speed: examination of metabolic, perceptual, spatiotemporal and stability parameters حسب Lina Majed (7485380)

"…While metabolic, perceptual and spatiotemporal values were sensitive to the smallest change in speed (i.e., 0.5 km·h⁻¹⁾, a significant increase in the rate of carbohydrate oxidation and decrease in % fat oxidation were only observed at speeds above PWS. …"

Biomolecular alterations in acute traumatic brain injury (TBI) using Fourier transform infrared (FTIR) imaging spectroscopy حسب Fazle Rakib (5768069)

"…Our results revealed that the total lipid and total protein content decreased significantly in the hippocampus, corpus callosum and thalamus after brain injury. …"

Effect of acute and chronic moderate alcohol consumption on fasted and postprandial lipemia in the rat حسب Daher, Costantine F.

"…In the fasted state, plasma TAG and total apoB concentrations are not modified in these animals, and an increase in HDL and a decrease in total and LDL cholesterol concentrations are observed. …"
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Arsenic: A double-edged sword حسب Nature Research (16552612)

"…Long-term exposure significantly increases the risk of heart disease, diabetes, and makes numerous different cell types turn cancerous. …"

Role of PDE3 and PDE4 for β-adrenergic control of cAMP and ICa,L in adult rat ventricular myocytes حسب Leroy, Jerome

"…Isoprenaline (Iso, 100 nM, 15 s) induced a transient increase in both [cAMP] i and I Ca,L. …"
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Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis حسب Maria K. Smatti (4675852)

"…Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations.</p><h3>Conclusion</h3><p dir="ltr">Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. …"

High flow nasal oxygen (HFNO) in the treatment of COVID-19 infection of adult patients from – An emergency perspective: A systematic review and meta-analysis حسب Nabil Shallik (15900256)

"…HFNO was associated with a significant decrease in mortality and intubation rates (0.28 (95% CI; 0.19, 0.39) and 0.28 (95% CI; 0.18, 0.41), respectively). …"

Effects of ethanol addition to diesel–biodiesel blends on the CI engine characteristics حسب Fakher Hamdi (21225134)

"…Biodiesel addition significantly increases carbon monoxide (CO) emissions, reaching an average of 190% across all speeds. …"

The protective role of lidocaine in surgeries involving trigeminal nerve manipulation: a meta-analysis of trigeminocardiac reflex prevention حسب Almonzer Al-Qiami (22393303)

"…Additionally, the lidocaine group had a relatively small change in HR, with a mean difference of -10.56 (95% CI -13.30 to -7.83 beat per minute, <i>P</i> = 0.00001). No statistically significant difference in mean arterial pressure was observed between the two groups (MD -5.15, 95% CI [-10.38 to 0.08 mmHg], <i>P</i> = 0.09). …"

Analyzing the Influence of Climate and Anthropogenic Development on Vegetation Cover in the Coastal Ecosystems of GCC حسب Abhilash Dutta Roy (22466830)

"…Our results revealed significant changes in land cover, as seen by an increase in artificial built-up areas by 15.5% in two decades and a corresponding decrease in bareland and dense vegetation. …"