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significant increased » significant increase (Expand Search), significant increases (Expand Search), significantly increased (Expand Search)
significantly reduce » significantly reduced (Expand Search), significantly greater (Expand Search)
increased release » increased reliance (Expand Search), increased relative (Expand Search), increased levels (Expand Search)
reduce decrease » reduce disease (Expand Search), reduce depressive (Expand Search), induces decreased (Expand Search)
significant increased » significant increase (Expand Search), significant increases (Expand Search), significantly increased (Expand Search)
significantly reduce » significantly reduced (Expand Search), significantly greater (Expand Search)
increased release » increased reliance (Expand Search), increased relative (Expand Search), increased levels (Expand Search)
reduce decrease » reduce disease (Expand Search), reduce depressive (Expand Search), induces decreased (Expand Search)
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In microglia, C1 reduced NO release triggered by IFNγ and PolyIC, and did not affect LPS induced cytokine release.
Published 2023“…Treatment with C1 (in blue) did not have a significant effect for the LPS-induced IL6 and TNFα release, but increased the release of IL1β at all tested concentrations (0.025 μM: p = 0.0037, 0.25 μM: p < 0.0001, 2.5 μM: p < 0.0001). …”
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C1 alone does not evoke NO release, an increase in cell activity or release of pro-inflammatory cytokines.
Published 2023“…As shown in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0278325#pone.0278325.g001" target="_blank">Fig 1</a></b>, LPS stimulation induced a significant increase in NO release (p<0.0001). Treatment with C1 or DMSO did not show any significant difference compared to untreated microglia (in white). …”
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