The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects by Ilhame Diboun (3522413)

“…<p dir="ltr">Familial hypercholesterolemia (FH) is an inherited disease characterized by reduced efficiency of low-density lipoprotein-cholesterol (LDL-C) removal from the blood and, consequently, an increased risk of life-threatening early cardiovascular complications. …”

Efficacy and safety of aldafermin in non-alcoholic steatohepatitis: A systematic review and meta-analysis of randomized controlled trials by Mohamed Mahmoud Marey (18560902)

“…<h3>Background</h3><p dir="ltr">Non-alcoholic steatohepatitis (NASH) is an advanced subtype of non-alcoholic fatty liver disease (NAFLD). NASH prevalence is increasing exponentially and carries a high risk for disease progression, cirrhosis, and liver-related mortality. …”

Why do some countries produce more capital intensive output than others? by Toukan, Amjad

“…Based on my model I offer an explanation for the variation in physical capital intensity across countries where the model predictions show that a lower quality of governance in a country results in a decrease in the output of capital-intensive goods and an increase in the output of labor-intensive goods. …”
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On the benefits of sleep by Nature Research (16552612)

“…It is well known that sleep deprivation can significantly affect cognitive functions such as attention and memory. …”

Safety and efficacy of ensifentrine in COPD: A systemic review and meta-analysis by Ambanna Yappalparvi (21260018)

“…<h3>Background</h3><p dir="ltr"><u>Chronic obstructive pulmonary disease </u>(COPD) significantly impacts global health due to persistent airflow limitation and inflammation. …”

Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism by Khaoula Errafii (10914446)

“…We compared the transcriptome profiles of untreated steatotic, and Ex-4-treated steatotic cells, and used Ingenuity Pathway Analysis (IPA) to identify the signaling pathways and associated genes involved in the protective effect of Ex-4. Ex-4 treatment significantly reduces steatosis. RNA-seq analysis revealed 209 differentially expressed genes (DEGs) between steatotic and untreated cells, with farnesoid X receptor/retinoid X receptor (FXR/RXR) (p = 8.9 × 10⁻⁷) activation being the top regulated canonical pathway identified by IPA. …”

The characteristics of <i>CALR</i> mutations in myeloproliferative neoplasms: a clinical experience from a tertiary care center in Qatar and a literature review by Mostafa Najim (14150400)

“…</p><h3>Conclusion</h3><p dir="ltr">The data shows a significant rise in CALR-positive MPN diagnoses in younger people, emphasizing the need for a better assessment tool to improve disease management and reduce complications.…”

Factors associated with mental health outcomes among medical residents exposed to COVID-19 by Mohamed Adil Shah Khoodoruth (14722588)

“…However, data on the psychological impact of infectious disease outbreaks, and COVID-19 in particular, on medical residents are relatively lacking.…”

Challenges of morbid obesity in gynecological practice by Albert A. Opoku (17019078)

“…Obesity affects several aspects of health, with increased risks of cardiovascular disease, diabetes, metabolic syndrome, and several malignancies.…”

A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle by Sanjay Kumar (8853)

“…By examining the effects of glycosylation and other structural-activity relationships, the presence of sugar moiety in flavonoids significantly reduces its binding energy. It increases the solubility of flavonoids leading to reduced toxicity and higher bioavailability. …”

Dextran Sodium Sulfate-Induced Impairment of Protein Trafficking and Alterations in Membrane Composition in Intestinal Caco-2 Cell Line by Toutounji, Mohamad

“…The present study investigates endoplasmic reticulum (ER) stress in addition to alterations in protein and membrane trafficking in a dextran sulfate sodium (DSS)-induced IBD-like phenotype of intestinal Caco-2 cells in culture. DSS treatment significantly reduced the transepithelial electric resistance (TEER) and increased the epithelial permeability of Caco-2 cells, without affecting their viability. …”
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Prevalence, correlates and management of hyperglycemia in diabetic non-critically Ill patients at a tertiary care center in Lebanon by El Khoury, Ghada

“…Background: Diabetes Mellitus is a chronic metabolic disease that affects 387 million people around the world. …”
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Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction by Daniel E. Platt (13982757)

“…</p><h3>Results</h3><p dir="ltr">We found that Hc levels were significantly reduced among subjects with diabetes compared to those without diabetes when adjusted for all potential confounders (OR 0.640; 95% CI [0.44–0.92]; <i>p</i> = 0.0200). …”

Effect of clinical hyperthyroidism and hypothyroidism on patent diabetes. 59 cases by Hirbli, K.

“…This incidence was significantly higher than the calculated probability of the two diseases occurring by chance in the same patient. …”
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Neonatal autoimmune lymphoproliferative syndrome with a novel pathogenic homozygous FAS variant effectively treated with sirolimus: Case report by Fawzia M. Elgharbawy (17045534)

“…(lle259*). Sirolimus significantly reduced DNTs and substantially relieved the patient’s clinical symptoms.…”

A GHRHR founder mutation causes isolated growth hormone deficiency type IV in a consanguineous Pakistani family by Safeer Ahmad (9079257)

“…</p><h3>Results</h3><p dir="ltr">All affected individuals presented with a short stature without gross skeletal anomalies and significantly reduced serum GH levels. Genetic mapping revealed a homozygous nonsense mutation [NM_000823:c.G214T:p.…”

Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. by Sara, Sokary

“…Semaglutide also slowed weight regain and promoted weight loss after failed bariatric surgery. It also significantly reduced ad libitum energy intake, decreased hunger, and increased satiety in multiple trials. …”
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Cathelicidin LL-37-induced transcriptome of human keratinocyte identifies chemokine CXCL10 link to T cell-mediated rosacea pathogenesis via JAK-1/STAT-1 pathway by Abdul W. Ansari (14557391)

“…<p dir="ltr">Rosacea is a chronic inflammatory disease of facial skin with unknown pathophysiology. …”

Encapsulation and Release of Calcein from Herceptin-conjugated eLiposomes by Zafar, Mah Noor

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Carbon dioxide insufflation during ERCP for reduction of postprocedure pain by Azar, Riad

“…Patients: This study involved consecutive patients presenting for ERCP, excluding those with significant preprocedure pain or obstructive lung disease. …”
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