The Paget's disease of bone risk gene <i>PML</i> is a negative regulator of osteoclast differentiation and bone resorption حسب Sachin Wani (11704868)

"…<p dir="ltr">Paget's disease of bone (PDB) is characterized by focal increases in bone remodelling. …"

The Next Decade of Cardiovascular Disease Burden in Qatar, a Gulf Cooperation Council Country: Projections from 2024 to 2033 حسب Dina Abushanab (10696501)

"…<h3>Background</h3><p dir="ltr">Cardiovascular diseases (CVD) are a great public health challenge in Qatar, with significant impacts on long-term population health and societal costs. …"

A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report حسب Mohamed Kamal Sabra (17075230)

"…</p><p dir="ltr">Graves' disease causes a large spectrum of clinical manifestations. …"

Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket حسب Angelos, Thanassoulas

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PFDI: a precise fruit disease identification model based on context data fusion with faster-CNN in edge computing environment حسب Poonam Dhiman (12889038)

"…The results show that the model size with 60–90% pruning can be counteracted to the 47.64 of the baseline model without significant loss of accuracy. Moreover, post-quantization can reduce the 60–90% pruning from 28.16 to 8.72. …"

Using Shockwave Lithotripsy to Treat Severe Calcified Mitral Stenosis in a Pregnant Woman حسب Mhd Baraa Habib (11721774)

"…Due to a high Wilkins score, PBMV was attempted with a 28 mm Inoue balloon inflated to 28 mm, but was suboptimal due to significant valve rigidity. Adjunctive TMVL improved valve pliability, successfully reducing the mitral gradient and increasing valve area without worsening MR. …"

Antifungal activity of green synthesized selenium nanoparticles and their effect on physiological, biochemical, and antioxidant defense system of mango under mango malformation dis... حسب Muhammad Shahbaz (772838)

"…The antioxidant defense system was also explored, and it was reported that green synthesized SeNPs significantly reduced the biotic stress by enhancing enzymatic and non-enzymatic activities. …"

Endocardial-Epicardial Catheter Ablation Versus Endocardial Catheter Ablation Alone for Ventricular Arrhythmia in Patients With Structural Heart Disease (Meta-Analysis of Reconstru... حسب Nour Shaheen (14034758)

"…<p>Endocardial-epicardial (Endo-epi) catheter ablation (CA) has been shown to reduce the rate of ventricular arrhythmia (VA) ablation in patients with structural heart disease (SHD). …"

Subclinical Myocardial Dysfunction Assessment Using Speckle Tracking Echocardiography in Patients With Psoriasis: A Pilot Meta‐Analysis حسب Hritvik Jain (19757091)

"…<h3>Introduction</h3><p dir="ltr">Psoriasis is a systemic inflammatory disease associated with elevated cardiovascular risk due to inflammatory and oxidative stress. …"

Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function حسب Sahar I. Da'as (17128747)

Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity حسب Mohammed R. Shaker (10316180)

"…These neurons were next exposed to pre-aggregated β-amyloid 1–42 oligomers to model the neurotoxicity associated with Alzheimer’s disease. Our data reveal that upregulation of <i>KLOTHO</i> significantly reduced β-amyloid-induced neuronal degeneration and apoptosis, as evidenced by decreased cleaved caspase-3 expression and preservation of axonal integrity. …"

Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-... حسب Mohamed Yassin (4166515)

"…<p>This systematic review aims to summarise the clinical outcomes of l-glutamine, crizanlizumab, and voxelotor in the treatment of sickle cell disease (SCD) based on clinical trials and real-world data and to identify any gaps in the observations. …"

Investigating the Role of Acetyl-CoA Synthetase Short Chain Family Member 2 (ACSS2) in Inflammatory Bowel Disease: Expression in Clinical Samples and Insights from In Vitro Models حسب Mezher, Nawal

"…Using Caco-2 and HT-29 intestinal epithelial cell lines stimulated with Tumor Necrosis Factor-α (TNF-α) or Dextran Sodium Sulfate (DSS) as in vitro models of inflammation, we observed upregulation of ACSS2 protein expression. ACSS2 inhibition significantly reduced the expression of pro-inflammatory cytokines such as Interleukin 8 (IL-8), IL-1β, and TNF-α, and attenuated activation of NF-κB and MAPK signaling pathways, as evidenced by decreased phosphorylation of p65 and ERK/MEK. …"
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Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd... حسب Katherine R Paulson (8674293)

"…NMR and U5MR were generally higher in males than in females, although there was no statistically significant difference at the global level. Neonatal disorders remained the leading cause of death in children younger than 5 years in 2019, followed by lower respiratory infections, diarrhoeal diseases, congenital birth defects, and malaria. …"

Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems حسب Local Burden of Disease HIV Collaborators (13279180)

"…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …"

Menstrual hygiene management inequalities among school girls in Badagry, Nigeria حسب Ruth C. Uwadia (14779633)

Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket حسب Angelos Thanassoulas (2822861)

Promising approaches for controlled pulmonary drug delivery حسب Nature Research (16552612)

"…“Much research needs to be done in order to enhance them [and] deliver drugs efficiently to treat not only lung diseases but also diseases in [other parts of] the body.”…"

Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation حسب Radhakrishnan Vishnubalaji (3563306)

"…<div><p>Triple-negative breast cancer (TNBC) patients exhibiting pathological complete response (pCR) have better clinical outcomes compared to those with residual disease (RD). Therefore, robust biomarkers that can predict pCR may help with triage and resource prioritization in patients with TNBC. …"

The protective effects of conditioned media from human mesenchymal stem cells against Methylglyoxal-mediated injury of cultured endothelial cells حسب Maram Hasan (6672440)