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Gut Microbiota in Familial Mediterranean Fever: Insights into Microbial Patterns and Disease Severity
منشور في 2025"…Our findings revealed no significant differences in gut microbiota composition or diversity between FMF patients and healthy controls, nor among FMF subgroups stratified by disease severity. …"
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masterThesis -
42
Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease
منشور في 2023"…<p dir="ltr">Alzheimer disease (AD) is a leading cause of dementia in elderly patients who continue to live between 3 and 11 years of diagnosis. …"
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43
The role of ulnar nerve subcutaneous anterior transposition during open reduction and internal fixation of distal humerus fractures: a retrospective cohort study
منشور في 2022"…</p> <h2>Conclusion</h2> <p>We do not recommend performing routine subcutaneous ulnar nerve anterior transposition during ORIF of distal humerus fracture as it was associated with a significant 5-fold increase in ulnar nerve neuropathy.…"
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44
Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis...
منشور في 2021"…Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. …"
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45
Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway
منشور في 2022"…Further treatment with 200 nM Ex-4 for 3 h significantly reduced the OA-induced lipid accumulation (p < 0.05). …"
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46
Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease
منشور في 2012"…Pancreatic tumors are usually diagnosed at an advanced stage in the progression of the disease, thus reducing the survival chances of the patients. …"
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article -
47
The role of preoperative transfusion in sickle cell disease, a systematic review and meta-analysis
منشور في 2024"…Notably, the increased bleeding risk observed seldom had clinical significance. We recommend individualizing management strategies, considering the overall positive impact of transfusions in reducing complications. …"
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48
Trends of the Dementia Burden in South Asia: An Analysis of 2021 Global Burden of Disease Study
منشور في 2025"…While prevalence rates experienced a minor decline, Disability‐Adjusted Life Years (DALYs) rose from 272.02 to 308.27 per 100,000, reflecting an increasing burden of the disease. Notably, Nepal significantly reduced its incidence rates, while Pakistan saw an increase in mortality rates. …"
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49
Zooming Into Clarity: Image Denoising Through Innovative Autoencoder Architectures
منشور في 2024"…<p dir="ltr">In today’s era of increasing data complexity and pervasive noise, robust techniques for data processing, reconstruction, and denoising are crucial. …"
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Reduced graphene aerogels as energy efficient selective oil sorbents
منشور في 2022"…The presence of H<sub>2</sub> significantly decreased the oxygen-containing functional groups in graphene aerogel. …"
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53
Pill-burden and its association with treatment burden among patients with advanced stages of chronic kidney disease
منشور في 2023"…IntroductionChronic kidney disease (CKD) is associated with multimorbidity and high treatment burden. …"
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article -
54
Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease
منشور في 2015"…This treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. …"
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55
Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation study
منشور في 2024"…Pyruvic acid and valine were consistently reduced in the discovery and validation cohorts. Pathway analysis of significantly altered metabolites in the validation set revealed that they are involved in branched-chain amino acids (BCAAs) and energy metabolism (glycolysis and gluconeogenesis). …"
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56
The effect of Dopamine Agonists on patients with advanced Parkinson's disease subjected to subthalamic deep brain stimulation. (c2000)
منشور في 2000"…Striatal dopamine concentration gets significantly reduced, and clinical symptoms, especially the motor handicap, prevail. …"
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masterThesis -
57
Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity
منشور في 2022"…Functional enrichment analysis revealed long-chain polyunsaturated fatty acids (n-3 and n-6) as the pathway exhibiting the most significant changes with increased disease severity in hypertensive patients (FDR = 0.07).…"
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A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction
منشور في 2019"…Knock down of JCAD using siRNA in primary human aortic endothelial cells significantly reduced the response to acute onset of flow, as evidenced by reduced phosphorylation of NF-КB, eNOS, and Akt.…"
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60
Dilemma of Tocilizumab therapy for a patient with critical COVID‐19 disease and neutropenia: Case report and review of the literature
منشور في 2023"…<p>Infection following SARS-Co V-2 leading to COVID-19 disease is associated with significant morbidity and mortality. …"