Deleterious Effects of a GAD65 Monoclonal Autoantibody on Islet Function by Christiane S. Hampe (248347)

“…We recently studied effects of human monoclonal autoantibodies (mAb) derived from a pre-diabetic patient and demonstrated that a GAD65mAb penetrated and accumulated in beta cells and significantly reduced the insulin secretion rate (ISR). …”

Data Sheet 1_The ERF transcription factor TaERF13-2B functions as a negative regulator of drought tolerance in Arabidopsis and wheat.docx by Yang Yu (4292)

“…TaERF13-2B overexpression in Arabidopsis resulted in significantly reduced survival rates under drought conditions with decreased expression of stress-responsive and antioxidant enzyme genes, indicating that the TaERF13-2B gene elevated drought sensitivity in transgenic Arabidopsis. …”

CONSORT Flowchart of Participants. by Mitsuyo Nonaka (20827083)

“…The intervention group showed significantly reduced weight (median; baseline 1, post-intervention 0.975, follow-up 0.983, p <  0.001), and slightly reduced waist circumference (median; baseline 1, post-intervention 0.975, follow-up 0.975, p =  0.226); however, the control group showed no change. …”

Characteristics of specialists at day centers. by Mitsuyo Nonaka (20827083)

“…The intervention group showed significantly reduced weight (median; baseline 1, post-intervention 0.975, follow-up 0.983, p <  0.001), and slightly reduced waist circumference (median; baseline 1, post-intervention 0.975, follow-up 0.975, p =  0.226); however, the control group showed no change. …”

The Dataset used for Tables 1 and 3. by Mitsuyo Nonaka (20827083)

“…The intervention group showed significantly reduced weight (median; baseline 1, post-intervention 0.975, follow-up 0.983, p <  0.001), and slightly reduced waist circumference (median; baseline 1, post-intervention 0.975, follow-up 0.975, p =  0.226); however, the control group showed no change. …”

Data Sheet 1_Loss of a primary cilia protein ARL13B promotes TGFβ-1 induced EMT of RPE in proliferative vitreoretinopathy via increasing Smad3 expression.pdf by Wenjun Sui (22776290)

“…</p>Results<p>Immunofluorescence revealed significantly reduced ARL13B levels in α-SMA-positive cells as compared with Pan-CK-positive cells in an epiretinal membrane derived from retinal tears. …”

Table 1_Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.xlsx by Yue Bu (11357379)

“…In vivo, AB4 significantly reduced levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), decreased oxidative stress markers MDA and DHE, and increased GSH levels. …”

Table 2_Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.xlsx by Yue Bu (11357379)

“…In vivo, AB4 significantly reduced levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), decreased oxidative stress markers MDA and DHE, and increased GSH levels. …”

Table 3_Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.docx by Yue Bu (11357379)

“…In vivo, AB4 significantly reduced levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), decreased oxidative stress markers MDA and DHE, and increased GSH levels. …”

Basal HLH-30 activity is not accompanied by enriched nuclear localization and declines during neuronal aging. by Ruiling Zhong (22339779)

“…****<i>P</i> < 0.0001, ***<i>P</i> < 0.001, **<i>P</i> < 0.01, *<i>P</i> < 0.05, ns: not significant, Two-way ANOVA with Tukey post-test. <b>(G)</b> Relative <i><i>rab-7</i></i> mRNA abundance from whole-worm transcriptomic data shows reduced <i><i>rab-7</i></i> mRNA level in aging WT worms. …”

Supplementary Material for: Metabolic analysis of three-dimensional cultured gastrointestinal cancer cells suggests that L-arginine inhibits tumor growth by affecting the urea cycl... by Tanaka E. (4127287)

“…In OE33, S phase cells (determined using BrdU) were significantly reduced. In a comprehensive metabolic analysis of OE33, citrulline/ornithine levels were significantly lower in arginine-treated than in untreated cells. …”

Impact of carbon and nitrogen assimilation in Sargassum fusiforme (Harvey) Setchell due to marine heatwave under global warming - data by Xingda Sheng (20582644)

“…Morphologically, heatwave stress damaged the thylakoid structure and reduces the photosynthetic efficiency of algae, and accumulated NADPH, ATP, and α-ketoglutarate significantly, resulting in decreased content of mannitol, the photosynthetic product. …”

Table 1_Litter quality outweighs climate in driving grassland root decomposition.docx by Jingjing Yang (119262)

“…With respect to biotic factors, grazing (+7.51%) significantly increased decomposition, whereas vegetated soil (−27.84%), increased plant species richness (−4.99%), increased root litter richness (−5.93%), home-field decomposition (−4.34%), and soil biota exclusion (−10.40%) decreased it.…”

Table 1_Dupilumab relieves pruritus both in uremic pruritus and in atopic dermatitis with chronic kidney disease: a retrospective real-world study.docx by Qian Wang (32718)

“…</p>Results<p>After dupilumab treatment, the PP-NRS and 5D-IS scores of 12 AD patients with CKD and 10 UP patients were significantly decreased. The percentages of UP patients who achieved PP-NRS ≥ 4-point improvement and 5D-IS ≤ 10-point at week 4, 12, and 16 did not significantly differ from those of AD patients with CKD (p > 0.05). …”

A lineage 1 branch porcine reproductive and respiratory syndrome virus live vaccine candidate provides broad cross-protection against HP-like PRRSV in piglets by Chao Li (145513)

“…The results revealed that piglets challenged with DLF presented clinical symptoms such as continuous high fever and an obvious decrease in daily weight gain. Importantly, the piglets immunised with SD-R exhibited notable reductions in pathological damage, especially of decreases in DLF-induced thymic atrophy. …”

Menadiol diacetate mediated subcellular Cd accumulation and nutrients uptake alleviates Cd toxicity and increases growth and yield of summer squash by Wajeeha Yaseen (20278314)

“…The exogenous MD not only reduced Cd toxicity but also significantly enhanced growth and yield of summer squash by increasing photosynthetic pigments and antioxidative potential.…”

Image 1_The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells.tif by Jianguo Zhang (6482)

“…E2F1 was identified as an upstream regulator of EIF4EBP1, with knockdown of E2F1 significantly decreasing EIF4EBP1 promoter activity and binding. …”

Table 1_Linking the Planetary Health Diet Index to sarcopenia: the mediating effect of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (N... by Huan Chen (6545)

“…Analysis of the dose–response curve suggested a linear relationship between PHDI and sarcopenia. Furthermore, a significant positive association was identified between NHHR and sarcopenia [OR = 1.09, 95% CI: 1.03, 1.16], with NHHR found to decrease as PHDI increased [beta coefficient (β) = −0.09, 95% CI: −0.11, −0.06]. …”

Table2_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”

Image1_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.tif by Bing Cui (179696)

“…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …”