Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease حسب Ramadan, Wijdan H.

"…For patients not sufficiently controlled on a single long-acting bronchodilator, a combination of different bronchodilators has shown a significant increase in lung function. Tiotropium, a once-daily dosing LAMA, demonstrated sustained improvements in lung function as well as improved health-related quality of life, reduced exacerbations, and increased survival without altering the rate of decline in the mean forced expiratory volume in 1 second (FEV1) with fairly tolerable side effects. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease حسب Sudharsana Sundarrajan (3181371)

"…<p dir="ltr">Alzheimer disease (AD) is a leading cause of dementia in elderly patients who continue to live between 3 and 11 years of diagnosis. …"

Systematic analysis of healthcare big data analytics for efficient care and disease diagnosing حسب Sulaiman Khan (12585349)

"…It contains a gigantic amount of data, especially a plethora of data types that has been significantly useful in diverse research domains. In healthcare domain, the researchers use computational devices to extract enriched relevant information from this data and develop smart applications to solve real-life problems in a timely fashion. …"

Air pollution burden of disease over highly populated states in the Middle East حسب Rima J. Isaifan (8350056)

"…</p><h3>Conclusions </h3><p dir="ltr">The results indicate a significant impact of air pollution due to long-term exposure to fine particles resulting in early mortality. …"

Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway حسب Olfa Khalifa (10914452)

"…Further treatment with 200 nM Ex-4 for 3 h significantly reduced the OA-induced lipid accumulation (p < 0.05). …"

Trends of the Dementia Burden in South Asia: An Analysis of 2021 Global Burden of Disease Study حسب Shubham Chauhan (21334742)

"…While prevalence rates experienced a minor decline, Disability‐Adjusted Life Years (DALYs) rose from 272.02 to 308.27 per 100,000, reflecting an increasing burden of the disease. Notably, Nepal significantly reduced its incidence rates, while Pakistan saw an increase in mortality rates. …"

Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease حسب El Maarri, Osman

"…Pancreatic tumors are usually diagnosed at an advanced stage in the progression of the disease, thus reducing the survival chances of the patients. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... حسب Marissa B Reitsma (8674341)

"…</p><p><br></p><h3>Methods</h3><p dir="ltr">We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. …"

The role of preoperative transfusion in sickle cell disease, a systematic review and meta-analysis حسب Yasamin Abdu (15899155)

"…Notably, the increased bleeding risk observed seldom had clinical significance. We recommend individualizing management strategies, considering the overall positive impact of transfusions in reducing complications. …"

Favipiravir for the treatment of coronavirus disease 2019 pneumonia; a propensity score-matched cohort study حسب Rand A. Alattar (9538554)

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease حسب Abid Oueslati (816135)

"…This treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. …"

Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation study حسب Jonas Ellegaard Nielsen (21633062)

"…Pyruvic acid and valine were consistently reduced in the discovery and validation cohorts. Pathway analysis of significantly altered metabolites in the validation set revealed that they are involved in branched-chain amino acids (BCAAs) and energy metabolism (glycolysis and gluconeogenesis). …"

Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity حسب Mohamed A. Elrayess (7956179)

"…Functional enrichment analysis revealed long-chain polyunsaturated fatty acids (n-3 and n-6) as the pathway exhibiting the most significant changes with increased disease severity in hypertensive patients (FDR = 0.07).…"

The effect of Dopamine Agonists on patients with advanced Parkinson's disease subjected to subthalamic deep brain stimulation. (c2000) حسب Jabre, Mazen Gerges

"…Striatal dopamine concentration gets significantly reduced, and clinical symptoms, especially the motor handicap, prevail. …"
احصل على النص الكامل
احصل على النص الكامل

Pill-burden and its association with treatment burden among patients with advanced stages of chronic kidney disease حسب Asmaa, Al-mansouri

"…IntroductionChronic kidney disease (CKD) is associated with multimorbidity and high treatment burden. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction حسب Gillian Douglas (7759118)

"…Knock down of JCAD using siRNA in primary human aortic endothelial cells significantly reduced the response to acute onset of flow, as evidenced by reduced phosphorylation of NF-КB, eNOS, and Akt.…"

Enhancing the notification system for surveillance of infectious diseases in Qatar during the FIFA World Cup 2022: project overview حسب Wafa Ibrahim (18067631)

"…</p><h3>Results</h3><p dir="ltr">There was significant improvement in the infectious disease notification process. …"

Dilemma of Tocilizumab therapy for a patient with critical COVID‐19 disease and neutropenia: Case report and review of the literature حسب Ahmad Al Bishawi (14148810)

"…<p>Infection following SARS-Co V-2 leading to COVID-19 disease is associated with significant morbidity and mortality. …"

The Paget's disease of bone risk gene <i>PML</i> is a negative regulator of osteoclast differentiation and bone resorption حسب Sachin Wani (11704868)

"…<p dir="ltr">Paget's disease of bone (PDB) is characterized by focal increases in bone remodelling. …"

The effect of Ramadan focused education on patients with type 2 diabetes: A systematic review and meta-analysis حسب Hoda Gad (6470522)

"…</p><h3>Conclusions</h3><p dir="ltr">This systematic review and meta-analysis shows that Ramadan-focused diabetes education leads to a decrease in HbA1c and LDL, but an increase in TG and weight during Ramadan. …"