Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity حسب Mohammed R. Shaker (10316180)

"…These neurons were next exposed to pre-aggregated β-amyloid 1–42 oligomers to model the neurotoxicity associated with Alzheimer’s disease. Our data reveal that upregulation of <i>KLOTHO</i> significantly reduced β-amyloid-induced neuronal degeneration and apoptosis, as evidenced by decreased cleaved caspase-3 expression and preservation of axonal integrity. …"

Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function حسب Sahar I. Da'as (17128747)

Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-... حسب Mohamed Yassin (4166515)

"…<p>This systematic review aims to summarise the clinical outcomes of l-glutamine, crizanlizumab, and voxelotor in the treatment of sickle cell disease (SCD) based on clinical trials and real-world data and to identify any gaps in the observations. …"

Investigating the Role of Acetyl-CoA Synthetase Short Chain Family Member 2 (ACSS2) in Inflammatory Bowel Disease: Expression in Clinical Samples and Insights from In Vitro Models حسب Mezher, Nawal

"…Using Caco-2 and HT-29 intestinal epithelial cell lines stimulated with Tumor Necrosis Factor-α (TNF-α) or Dextran Sodium Sulfate (DSS) as in vitro models of inflammation, we observed upregulation of ACSS2 protein expression. ACSS2 inhibition significantly reduced the expression of pro-inflammatory cytokines such as Interleukin 8 (IL-8), IL-1β, and TNF-α, and attenuated activation of NF-κB and MAPK signaling pathways, as evidenced by decreased phosphorylation of p65 and ERK/MEK. …"
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The Impact of Artificial Intelligence on Commercial Arbitration حسب ELIMAM, HANI ELSAYED IBRAHIM

"…Artificial Intelligence (AI) is becoming increasingly integral to various sectors globally, with the United Arab Emirates (UAE) demonstrating notable interest and investment in this field. …"
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Improvement of Dialysis Dosing Using Big Data Analytics حسب Mumtaz, Syeda Leena

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Menstrual hygiene management inequalities among school girls in Badagry, Nigeria حسب Ruth C. Uwadia (14779633)

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd... حسب Katherine R Paulson (8674293)

"…NMR and U5MR were generally higher in males than in females, although there was no statistically significant difference at the global level. Neonatal disorders remained the leading cause of death in children younger than 5 years in 2019, followed by lower respiratory infections, diarrhoeal diseases, congenital birth defects, and malaria. …"

Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems حسب Local Burden of Disease HIV Collaborators (13279180)

"…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …"

Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket حسب Angelos Thanassoulas (2822861)

Modeling of photovoltaic soiling loss as a function of environmental variables حسب Wasim Javed (6105866)

"…The ANN model performed significantly better in predicting daily ΔCIas well as cumulative CI than the linear model in term of R2 values and statistical error indexes. …"

Promising approaches for controlled pulmonary drug delivery حسب Nature Research (16552612)

"…“Much research needs to be done in order to enhance them [and] deliver drugs efficiently to treat not only lung diseases but also diseases in [other parts of] the body.”…"

Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation حسب Radhakrishnan Vishnubalaji (3563306)

"…<div><p>Triple-negative breast cancer (TNBC) patients exhibiting pathological complete response (pCR) have better clinical outcomes compared to those with residual disease (RD). Therefore, robust biomarkers that can predict pCR may help with triage and resource prioritization in patients with TNBC. …"

The protective effects of conditioned media from human mesenchymal stem cells against Methylglyoxal-mediated injury of cultured endothelial cells حسب Maram Hasan (6672440)

Leptin is a potential biomarker of childhood obesity and an indicator of the effectiveness of weight‐loss interventions حسب Mohammad Al Zein (20090700)

Cardiovascular Efficacy and Safety of Finerenone: A Meta‐Analysis of Randomized Controlled Trials حسب Mushood Ahmed (19231379)

"…Finerenone use was associated with a trend of reduced risk of CV death without reaching statistical significance (RR 0.90, 95% CI: 0.81–1.00). …"

Mechanisms underlying the effects of caloric restriction on hypertension حسب Ahmad A. Al Attar (17563152)

"…<p>Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. …"

Investigation of the Effect of Exendin-4 on Oleic Acid-Induced Steatosis in HepG2 Cells Using Fourier Transform Infrared Spectroscopy حسب Olfa Khalifa (10914452)

"…Analysis of the Oil Red O staining showed that Ex-4 significantly reduces steatosis. This reduction was confirmed by FTIR analysis, as the phospholipid band (C=O) at 1740 cm−1 in Ex-4 treated cells is significantly decreased compared to steatotic cells. …"

Efficacy of Lebanese Cannabis Oil Extract in the Treatment of Folic Acid-Induced Renal Fibrosis in Rats حسب Bylan, Diana

"…Serum sodium was significantly reduced in all the groups receiving Cannabis oil extract. …"
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Cold responses and hormonal echoes: a comprehensive view of Raynaud’s vascular dysfunction حسب Manal Fardoun (16328847)

"…Interestingly, Raynaud’s phenomenon incidence is significantly higher in premenopausal females compared to age-matched males, highlighting a role of the female hormone, estrogen, in Raynaud’s phenomenon pathogenesis. …"