Image 4_The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways.tiff by Priscila Silva (556743)

“…</p>Results<p>Heat-inactivated OpdA significantly reduced metastasis, dependent on tumor-specific CD4+ and CD8+ T cells and IFN-γ, both locally and systemically, with decreased IL-10 levels suggesting a proinflammatory environment. …”

Table 3_Identification of potential miRNA biomarkers for neurobrucellosis diagnosis.xlsx by Meiling Liu (390553)

“…Among these, four common miRNAs (miR-342-3p, miR-576-5p, miR-15b-5p and miR-499a-5p) were significantly elevated in the infection group compared to controls in both the in-house and validation cohorts. …”

Table2_The long-term prognostic implications of free triiodothyronine to free thyroxine ratio in patients with obstructive sleep apnea and acute coronary syndrome.jpg by Yun Zhou (308977)

“…The FT3/FT4 ratio between OSA and non-OSA patients was not significantly different. During 2.8 (1.4, 3.5) years follow up, the risk of MACCE increased with the decreasing FT3/FT4 tertiles in patients with OSA (tertile3 as reference, tertile2: hazard ratio (HR) 1.26, 95% CI: 0.85-1.86, P = 0.255; tertile1: 1.60, 95% CI 1.11-2.32; P = 0.013). …”

Data Sheet 1_Comparative transcriptomics of two petal variants reveals key functional genes underlying petal shape development in lotus (Nelumbo).zip by Jiaxin He (11256475)

“…Introduction<p>The lotus (Nelumbo Adans.) is a versatile plant that integrates ornamental beauty, culinary applications, medicinal benefits, ecological significance, and cultural symbolism. However, its ornamental value is somewhat restricted by the relatively limited diversity in petal shapes. …”

Table 4_Identification of potential miRNA biomarkers for neurobrucellosis diagnosis.xlsx by Meiling Liu (390553)

“…Among these, four common miRNAs (miR-342-3p, miR-576-5p, miR-15b-5p and miR-499a-5p) were significantly elevated in the infection group compared to controls in both the in-house and validation cohorts. …”

Multivariate Binary Logistic Regression Analysis. by Feng Zhang (6548)

“…</p><p>Conclusion</p><p>Decreased RBC/ALB and elevated NLR may be pivotal factors contributing to false-negative IGRA results in PTB patients. …”

Image 1_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7... by Chunmei Ren (10921089)

“…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …”

Table 1_Global, regional, and national esophageal cancer deaths and DALYs attributable to diet low in vegetables and fruits, 1990–2019: analysis for the global burden of disease st... by Bing Cui (179696)

“…The disease burden attributable to insufficient fruit intake (51,210 deaths, 12,497,75 DALYs) was significantly higher than that from inadequate vegetable intake (17,176 deaths, 4,203,09 DALYs). …”

Table 2_Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model.xlsx by Zhijian Zha (19451405)

“…</p>Results<p>In the danazol-induced CPP model, luteolin treatment significantly decreased the abundances of Estradiol (E2), luteinizing hormone serum, and follicle-stimulating hormone in sera; reduced organ coefficients and ovarian and uterine wet weights; and delayed vaginal opening. …”

Data Sheet 1_Tcirg1 deficiency delays osteoarthritis progression by impairing lysosome acidification and peripheral accumulation in osteoclasts.docx by Rui Sun (177521)

“…</p>Results and discussion<p>Proteomic analysis revealed that TCIRG1 was significantly upregulated in the WBR compared to NWBR of subchondral bone in OA patients, with functional enrichment analysis indicating TCIRG1 correlation with lysosome-related biological processes. …”

Supplementary file 1_Quantitative microbial taxonomy across particle size, depth, and oxygen concentration.zip by Paulina Huanca-Valenzuela (21414911)

“…The microbial community varied statistically significantly as a function of particle size and depth. …”

Image 2_A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China.tif by Meirong Feng (22089665)

“…</p>Conclusion<p>HBV-LC patients in Northwest China exhibit altered clinical indicators, gut microbial composition (reduced diversity, increased opportunistic pathogens, decreased beneficial species), and metabolic function. …”

Table 2_Identification of potential miRNA biomarkers for neurobrucellosis diagnosis.xlsx by Meiling Liu (390553)

“…Among these, four common miRNAs (miR-342-3p, miR-576-5p, miR-15b-5p and miR-499a-5p) were significantly elevated in the infection group compared to controls in both the in-house and validation cohorts. …”

Image 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.png by Zebanuer Yuemaierjiang (22702064)

“…Mechanistically, β-PGG decreased PCID2 expression and downregulated Cyclin D1 and CDK6. …”

Image_3_Angiotensin-I-converting enzyme inhibitory peptides from eel (Anguilla japonica) bone collagen: preparation, identification, molecular docking, and protective function on H... by Huan Xiang (460100)

“…Treatment with GPPGPPGL significantly increased nitric oxide secretion (p < 0.01) and decreased endothelin-1 (ET-1) production in HUVECs.…”

Image 2_Establishment and validation of survival nomogram score staging for esophageal squamous cell carcinoma patients after minimally invasive surgery combined with immune progno... by Shao-jun Xu (11633956)

“…Accordingly, we developed the SNS staging and found that the OS and DFS were significantly different among patients at different stages (all P < 0.001). …”

Image 2_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png by Feifei Yang (334047)

“…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …”

Table1_The association of physical activity with kidney function risk among adults with long working hours.docx by Tenglong Yan (14132220)

“…Introduction<p>Long working hours are likely associated with the decreased of kidney function, while physical activity (PA) was linked to improvements in kidney function. …”

Image 3_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7... by Chunmei Ren (10921089)

“…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …”

Table 3_The effects of acute and chronic exercise on immune markers of TH1/TH2 cells in older adults: a systematic review.docx by Thiago Henrique Teodoro (20703731)

“…</p>Conclusion<p>Chronic exercise decreases serum TNF-α and IL-6 levels, lowers the CD4/CD8 ratio, and increases IL-10 after 24 weeks, aiding Th1 and Th2 balance. …”