Multi-omics revealed GOT1/ALDH3A1 pathway attenuated head and neck squamous cell carcinoma and increased cisplatin sensitivity through ROS induced by mitochondrial dysfunction حسب Zhihui Liu (95891)

"…Given that mitochondria are the primary source of reactive oxygen species (ROS), we assessed cellular ROS and mitochondrial superoxide levels by flow cytometry and found a significant increase. GOT1 knockdown increased the sensitivity of cells to cisplatin and decreased the volume of tumors in vivo. …"

Table 6_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv حسب Zhenyu Zhao (737165)

"…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…"

Table 5_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv حسب Zhenyu Zhao (737165)

"…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…"

Table 8_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv حسب Zhenyu Zhao (737165)

"…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…"

Roxadustat alleviates cisplatin-induced acute kidney injury by regulating fatty acid oxidation and mitochondrial function حسب Xialin Li (20449207)

"…</p> <p>Pretreatment with roxadustat significantly improved kidney function in the AKI model, as evidenced by reductions of Scr and BUN, and alleviated cisplatin-induced kidney morphology lesions. …"

Data Sheet 1_Lactobacillus paragasseri HM018 derived from breast milk ameliorates hyperlipidemia in high-cholesterol rats by modulating bile acid metabolism.docx حسب Chunyu Yao (13559263)

"…Concurrently, hepatic Cocs2/3 and Cish gene expression was downregulated, attenuating their inhibitory effects on hormonal and glucagon signaling, thereby improving glucose and lipid metabolism. Metabolomic profiling further indicated that HM018 significantly altered bile acid composition by modulating gut microbiota-mediated bile acid metabolism. …"

Data Sheet 1_Aloe-emodin plus TIENAM ameliorate cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating microbiota.docx حسب Jingqian Su (666622)

"…Moreover, substantial improvements in survival rates of AE + TIE-treated mice (10% to 60%) within 168 h were observed relative to the CLP group. …"

Table 1_Safety and efficacy of canine recombinant IL-15 in mammary gland tumors.docx حسب Min-Hee Kang (811734)

"…Dogs in the rcIL-15 group showed significantly improved QoL, particularly in pain, appetite, and activity. …"

Data Sheet 1_Decoding population PM2.5 exposure in China: interplay of emissions, meteorology, and inequality (2013–2020).docx حسب Sujing Li (564578)

"…<p>Over the past decade, China has significantly improved air quality by integrating environmental policies with economic growth. …"

Data Sheet 1_Microbial network-driven remediation of saline-alkali soils by salt-tolerant plants.docx حسب Yushuang Cui (2265055)

"…The results indicated that the planting of TC, TA, and HM effectively reduced soil electrical conductivity (EC) by 82.9, 88.3, and 86.2%, respectively. TC and TA significantly decreased the pH from 8.79 to 8.35 and 8.06, respectively, (p < 0.05). …"

Data Sheet 1_From psychological wellbeing to distress: the role of psychological counseling interventions in university students.pdf حسب Francesco Craig (8214780)

"…Post-intervention, psychological distress decreased significantly (p < 0.001), with 56.7% of students falling over the clinical distress cut-off at T1 compared to 84.4% at T0. …"

Supplementary file 1_Divergent germination strategies of Phragmites australis seeds for tidal flat gradient adaptation and the implications for coastal wetland restoration.docx حسب Peng Jia (194819)

"…With the increase in salinity, the germination speeds of different tidal flats slowed down, and the germination index decreased. 4°C storage significantly enhanced the seed germination rate and germination potential of the low-tidal flat population (L) relative to room-temperature storage. …"

Data Sheet 1_Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease.zip حسب Xi Luo (361139)

"…Both PD models predicted reduced uptake of lysine and lactate, indicating coordinated metabolic processes between these components. In contrast, decreased methionine and urea uptake was exclusively predicted in the synaptic PD model, while decreased histidine and glyceric acid uptake was exclusive to the non-synaptic PD model. …"

Table 1_Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease.docx حسب Xi Luo (361139)

"…Both PD models predicted reduced uptake of lysine and lactate, indicating coordinated metabolic processes between these components. In contrast, decreased methionine and urea uptake was exclusively predicted in the synaptic PD model, while decreased histidine and glyceric acid uptake was exclusive to the non-synaptic PD model. …"

Data Sheet 1_Chemopreventive and therapeutic effects of Hippophae rhamnoides L. fruit peels evaluated in preclinical models of breast carcinoma.docx حسب Dana Dvorska (19809111)

"…In the 4T1 mouse model, seaberry treatment resulted in a significant, dose-dependent reduction in tumor volume (43% and 48% compared to controls) and a decrease in the mitotic activity index. …"

Data Sheet 1_Mechanisms underlying the wound healing and tissue regeneration properties of a novel gauze dressing impregnated with traditional herbal medicine (Ya-Samarn-Phlae) in... حسب Sineenart Sanpinit (14836963)

"…</p>Results<p>During the 6-month storage period, the α-mangostin content measured in YaSP did not decrease; however, the curcumin level showed a significant reduction. …"

Table 1_How long do pathogens persist and survive in water? A systematic review.docx حسب Famous K. Sosah (22509419)

"…Viruses averaged 22 days of survival but could persist up to 1,095 days; Human Adenovirus and Porcine epidemic diarrhea virus were the most frequently studied viral pathogens, while Human Norovirus survived over 70 days in surface water at 37°C. Viral viability decreased significantly at extreme pH levels. Parasites/protozoans, such as Cryptosporidium parvum and Giardia lamblia only showed survival duration, averaged 30 days survival, enduring extreme conditions and often benefiting from biofilm association. …"

Table 2_A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical stud... حسب Xiao-Min Lv (21575681)

"…These mechanisms resulted in enhanced amplitude of A/B waves, improved retinal thickness and visual function.</p>Conclusion<p>Resveratrol has neuroprotective, anti-inflammatory and antioxidant effects through multiple mechanisms, thereby reducing retinal damage and maintaining the structure and function of the retina. …"

Table 1_A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical stud... حسب Xiao-Min Lv (21575681)

"…These mechanisms resulted in enhanced amplitude of A/B waves, improved retinal thickness and visual function.</p>Conclusion<p>Resveratrol has neuroprotective, anti-inflammatory and antioxidant effects through multiple mechanisms, thereby reducing retinal damage and maintaining the structure and function of the retina. …"

Image 2_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif حسب Lixuan Yang (7331786)

"…</p>Results<p>In rats with CSVD and depression, PY significantly increased body weight; alleviated depression-like behaviors; and decreased the levels of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in both serum and hippocampus. …"