Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…After coincubation with edited CMCs, the proportions of CD8+CD69+ and CD8+CD44+ T cells significantly increase, while the proportion of CD4+Foxp3+ T_regs notably decreases, indicating the restoration of immune responses. …”

Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…After coincubation with edited CMCs, the proportions of CD8+CD69+ and CD8+CD44+ T cells significantly increase, while the proportion of CD4+Foxp3+ T_regs notably decreases, indicating the restoration of immune responses. …”

Functional Delivery Systems for Targeting Tumor Heterogeneity: Reversing Immunosuppression and Modulating Cancer-Immune Interplay by Di Han (618795)

“…After coincubation with edited CMCs, the proportions of CD8+CD69+ and CD8+CD44+ T cells significantly increase, while the proportion of CD4+Foxp3+ T_regs notably decreases, indicating the restoration of immune responses. …”

Ultrafine Particulate Matter Exacerbates the Risk of Delayed Neural Differentiation: Modulation Role of METTL3-Mediated m⁶A Modification by Rui Wang (52434)

“…Furthermore, the efficacy of the METTL3 inhibitor in alleviating nerve differentiation impairments emphasizes the significance of this pathway. In addition, source analysis, molecular docking, and toxicity analyses show that PAHs with higher ring structures in PM_0.1 from combustion sources competitively bind to METTL3, potentially exacerbating neurodevelopmental toxicity. …”

Assessing Bivalves as Biomonitors of Per- and Polyfluoroalkyl Substances in Coastal Environments by Shannon E. Jones (17558652)

“…Overall, the summed PFAS concentration in the bivalves closely mirrors that in water. We observed higher bioaccumulation factors for some perfluoroalkyl sulfonamides and branched PFAS isomers than for terminal PFAS of equivalent chain length. …”

Results of redundancy analysis. by Bianhua Zhang (22430652)

“…<div><p>In order to clarify the effects of long-term coal gangue(CG) dump on the surrounding soil bacterial community structure, we selected the CG dump formed during the mining of Tunlan coal mine in Gujiao city, Shanxi province in China as the study area to conduct a comprehensive study, the experimental design included six distinct zones: control soil area with no impaction (NC), undisturbed control sediment area (NL), atmospheric dry and wet deposition area (MC), upstream (MLS), midstream (MLZ) and downstream (MLX) in the leachate flow area (LFA), Using high-throughput sequencing technology and related software analysis, we obtained the following key findings: The heavy metal contents of Cr and Cd were different significantly in MC and NC (p < 0.05),Cr (90.18 mg·kg-1) in MC was higher than that in NC (65.29 mg·kg-1) (p < 0.05), while Cd (0.09 mg·kg-1) was lower than that in NC (0.14 mg·kg-1) (p < 0.05), and there was no significant differences in Cu, Zn, As and Pb between MC and NC (p > 0.05). …”

Study Flowchart. by Jae-Heung Cho (798319)

“…<div><p>The effectiveness and cost-effectiveness of <i>Chuna</i> manual therapy (CMT) for temporomandibular joint disorders (TMD) remain unclear. Here, we compared the effectiveness of CMT and usual care for treating myofascial TMD. …”

Changes in outcomes over time. by Jae-Heung Cho (798319)

“…<div><p>The effectiveness and cost-effectiveness of <i>Chuna</i> manual therapy (CMT) for temporomandibular joint disorders (TMD) remain unclear. Here, we compared the effectiveness of CMT and usual care for treating myofascial TMD. …”

Study timetable. by Jae-Heung Cho (798319)

“…<div><p>The effectiveness and cost-effectiveness of <i>Chuna</i> manual therapy (CMT) for temporomandibular joint disorders (TMD) remain unclear. Here, we compared the effectiveness of CMT and usual care for treating myofascial TMD. …”

Cumulative incidence curves of recovery by group. by Jae-Heung Cho (798319)

“…<div><p>The effectiveness and cost-effectiveness of <i>Chuna</i> manual therapy (CMT) for temporomandibular joint disorders (TMD) remain unclear. Here, we compared the effectiveness of CMT and usual care for treating myofascial TMD. …”

S1 Data - by Francois Kiemde (5369657)

“…Cortisol and prolactin levels decreased after delivery, though the level of prolactin was still higher than that at enrolment. …”

Characteristic of study population. by Francois Kiemde (5369657)

“…Cortisol and prolactin levels decreased after delivery, though the level of prolactin was still higher than that at enrolment. …”

Model vs. WKY group KEGG pathways (Top 15). by Xiao Zhang (152326)

“…</p><p>Results</p><p>From Day 1–5, compared with the WKY group, both the Model and SHR groups exhibited shortened incubation periods and slower average swimming speeds (<i><i>P</i></i> < 0.01); On day 6, compared with the WKY group, the Model group showed a significant decrease in the number of platform crossings (<i><i>P</i></i> < 0.05), time spent in the target quadrant (<i><i>P</i></i> < 0.05), and total distance traveled in the target quadrant (<i><i>P</i></i> < 0.05). …”

Behavioral data. by Xiao Zhang (152326)

“…</p><p>Results</p><p>From Day 1–5, compared with the WKY group, both the Model and SHR groups exhibited shortened incubation periods and slower average swimming speeds (<i><i>P</i></i> < 0.01); On day 6, compared with the WKY group, the Model group showed a significant decrease in the number of platform crossings (<i><i>P</i></i> < 0.05), time spent in the target quadrant (<i><i>P</i></i> < 0.05), and total distance traveled in the target quadrant (<i><i>P</i></i> < 0.05). …”

OPLS-DA model parameter. by Xiao Zhang (152326)

“…</p><p>Results</p><p>From Day 1–5, compared with the WKY group, both the Model and SHR groups exhibited shortened incubation periods and slower average swimming speeds (<i><i>P</i></i> < 0.01); On day 6, compared with the WKY group, the Model group showed a significant decrease in the number of platform crossings (<i><i>P</i></i> < 0.05), time spent in the target quadrant (<i><i>P</i></i> < 0.05), and total distance traveled in the target quadrant (<i><i>P</i></i> < 0.05). …”

Model vs. SHR group KEGG pathways (Top 15). by Xiao Zhang (152326)

“…</p><p>Results</p><p>From Day 1–5, compared with the WKY group, both the Model and SHR groups exhibited shortened incubation periods and slower average swimming speeds (<i><i>P</i></i> < 0.01); On day 6, compared with the WKY group, the Model group showed a significant decrease in the number of platform crossings (<i><i>P</i></i> < 0.05), time spent in the target quadrant (<i><i>P</i></i> < 0.05), and total distance traveled in the target quadrant (<i><i>P</i></i> < 0.05). …”

Addressing Imbalanced Classification Problems in Drug Discovery and Development Using Random Forest, Support Vector Machine, AutoGluon-Tabular, and H2O AutoML by Ayush Garg (21090944)

“…The important findings of our studies are as follows: (i) there is no effect of threshold optimization on ranking metrics such as AUC and AUPR, but AUC and AUPR get affected by class-weighting and SMOTTomek; (ii) for ML methods RF and SVM, significant percentage improvement up to 375, 33.33, and 450 over all the data sets can be achieved, respectively, for F1 score, MCC, and balanced accuracy, which are suitable for performance evaluation of imbalanced data sets; (iii) for AutoML libraries AutoGluon-Tabular and H2O AutoML, significant percentage improvement up to 383.33, 37.25, and 533.33 over all the data sets can be achieved, respectively, for F1 score, MCC, and balanced accuracy; (iv) the general pattern of percentage improvement in balanced accuracy is that the percentage improvement increases when the class ratio is systematically decreased from 0.5 to 0.1; in the case of F1 score and MCC, maximum improvement is achieved at the class ratio of 0.3; (v) for both ML and AutoML with balancing, it is observed that any individual class-balancing technique does not outperform all other methods on a significantly higher number of data sets based on F1 score; (vi) the three external balancing techniques combined outperformed the internal balancing methods of the ML and AutoML; (vii) AutoML tools perform as good as the ML models and in some cases perform even better for handling imbalanced classification when applied with imbalance handling techniques. …”

Data Sheet 1_Statistics and behavior of clinically significant extra-pulmonary vein atrial fibrillation sources: machine-learning-enhanced electrographic flow mapping in persistent... by Peter Ruppersberg (22123543)

“…Significant sources persisting post-procedure were associated with significantly higher recurrence rates than those successfully ablated. …”

Functional Characterization of a Highly Efficient UDP-Glucosyltransferase CitUGT72AZ4 Involved in the Biosynthesis of Flavonoid Glycosides in Citrus by Bin Liao (714989)

“…Virus-induced gene silencing of <i>CitUGT72AZ4</i> significantly decreased the accumulation of flavonoid 4′-<i>O</i>-glucosides. …”

<i>trus</i> mutant displays higher embryonic lethality. by Saeko Takada (21616085)