Image_5_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_6_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_7_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_3_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_2_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_4_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Data_Sheet_3_Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum.xls by Maria Iuliano (6368759)

“…Lipidomic analysis of mouse fractions indicated that compared to those of wild-type, fractions 1 and 2 of 6 months Q175/Q7 HD had altered levels of two species of PIP2, a phospholipid involved in synaptic signaling, increased levels of cholesterol ester and decreased cardiolipin species. …”

Data_Sheet_2_Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum.xls by Maria Iuliano (6368759)

“…Lipidomic analysis of mouse fractions indicated that compared to those of wild-type, fractions 1 and 2 of 6 months Q175/Q7 HD had altered levels of two species of PIP2, a phospholipid involved in synaptic signaling, increased levels of cholesterol ester and decreased cardiolipin species. …”

Video_2_On the Importance of Spatial and Velocity Resolution in the Hybrid-Vlasov Modeling of Collisionless Shocks.mp4 by Yann Pfau-Kempf (5231036)

“…While the code remains numerically stable with all combinations of resolutions, it is shown that significantly increasing the resolution in one space but not the other leads to unphysical results. Past a certain level, decreasing the phase space density threshold bears a large computational weight without clear physical improvement in the setup used here. …”

Video_4_On the Importance of Spatial and Velocity Resolution in the Hybrid-Vlasov Modeling of Collisionless Shocks.MP4 by Yann Pfau-Kempf (5231036)

“…While the code remains numerically stable with all combinations of resolutions, it is shown that significantly increasing the resolution in one space but not the other leads to unphysical results. Past a certain level, decreasing the phase space density threshold bears a large computational weight without clear physical improvement in the setup used here. …”

Table_2_Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis.xlsx by Jianfeng Shu (12518655)

“…The mRNA and protein level of CPA3 was decreased, while the remaining six gene levels were increased in clinical tumor tissues.…”

DataSheet_3_Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis.pdf by Jianfeng Shu (12518655)

“…The mRNA and protein level of CPA3 was decreased, while the remaining six gene levels were increased in clinical tumor tissues.…”

Table_1_Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis.xlsx by Jianfeng Shu (12518655)

“…The mRNA and protein level of CPA3 was decreased, while the remaining six gene levels were increased in clinical tumor tissues.…”

Winter Activity of Coastal Plain Populations of Bat Species Affected by White-Nose Syndrome and Wind Energy Facilities by John F. Grider (297740)

“…To determine if warmer temperatures affect bat activity, we compared year-round activity of bat populations in the Coastal Plain and Piedmont of North Carolina, USA, two regions that differ in winter temperature. We established six recording stations, four along a 295-kilometer north-south transect in the Coastal Plain, and two in the Piedmont of North Carolina. …”

DataSheet_1_MicroLet-7b Regulates Neutrophil Function and Dampens Neutrophilic Inflammation by Suppressing the Canonical TLR4/NF-κB Pathway.pdf by Binzhen Chen (10489685)

“…We found that overexpression of miR-let-7b could significantly down-regulate the expression of human-derived neutrophilic TLR4 at a post-transcriptional level, a decreased level of proinflammatory factors including interleukin-6 (IL-6), IL-8, tumor necrosis factor α (TNF-α), and an upregulation of anti-inflammatory factor IL-10 in vitro. …”

Video_3_On the Importance of Spatial and Velocity Resolution in the Hybrid-Vlasov Modeling of Collisionless Shocks.mp4 by Yann Pfau-Kempf (5231036)

“…While the code remains numerically stable with all combinations of resolutions, it is shown that significantly increasing the resolution in one space but not the other leads to unphysical results. Past a certain level, decreasing the phase space density threshold bears a large computational weight without clear physical improvement in the setup used here. …”

S1 File - by Jinyan Feng (13016481)

“…And we explored the function of FDX1 in osteosarcoma by western blotting, CCK8, colony formation assay, wound healing assay and transwell assays.</p><p>Results</p><p>A total of six cuproptosis-mitochondrion genes (FDX1, COX11, MFN2, TOMM20, NDUFB9 and ATP6V1E1) were identified. …”

Table_3_Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis.xlsx by Jianfeng Shu (12518655)

“…The mRNA and protein level of CPA3 was decreased, while the remaining six gene levels were increased in clinical tumor tissues.…”

DataSheet_1_Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis.pdf by Jianfeng Shu (12518655)

“…The mRNA and protein level of CPA3 was decreased, while the remaining six gene levels were increased in clinical tumor tissues.…”

DataSheet1_UHPLC-MS profiles and antidiarrheal activity of Quercus coccinea münchh. and Quercus robur L. employing in vivo technique.pdf by Mohamed S. Mady (13151892)

“…The antidiarrheal potential of the obtained extracts was evaluated by conducting a castor oil-induced diarrhea in-vivo model.</p><p>Result and Discussion: Twenty-five and twenty-six polyphenolic compounds were tentatively identified in Q. coccinea and Q. robur AME, respectively. …”