N‑Heterocyclic Carbenes with a <i>N</i>‑2,4-Dinitrophenyl Substituent: Comparison with PPh₃ and IPr by Tetsuo Sato (2010571)

“…Synthesis and characterization of N-heterocyclic carbenes (NHCs) bearing a 2,4-dinitrophenyl (DNP) substituent on an NHC framework were performed. The treatment of 1-(2,4-dinitrophenyl)-1<i>H</i>-imidazole (<b>1</b>) with 1-bromo-2,4-dinitrobenzene or methyl triflate afforded imidazolium salts <b>2a</b>·HBr or <b>2b</b>·HOTf, respectively, which were corresponding precursors of NHC ligands 1,3-bis­(2,4-dinitrophenyl)-1<i>H</i>-imidazol-2-ylidene (<b>2a</b>) and 1-(2,4-dinitrophenyl)-3-methyl-1<i>H</i>-imidazol-2-ylidene (<b>2b</b>). …”

Table_1_Thoracoscopic Lobectomy Versus Sublobar Resection for pStage I Geriatric Non-Small Cell Lung Cancer.docx by Young-Jen Lin (11990831)

“…This study aimed to evaluate survival and perioperative outcomes after thoracoscopic lobectomy resection (LR) or sublobar resection (SR) in patients aged ≥75 years with pathologic stage (pStage) I NSCLC.</p>Materials and Methods<p>We retrospectively examined 258 consecutive patients aged ≥75 years with pStage I NSCLC who underwent thoracoscopic tumor resection at our institute from 2011 to 2018. …”

Regulation of Brain Tumor Dispersal by NKCC1 Through a Novel Role in Focal Adhesion Regulation by Tomas Garzon-Muvdi (168470)

“…Pharmacological inhibition and shRNA-mediated knockdown of NKCC1 expression led to decreased cell migration and invasion in vitro and in vivo. …”

Supplementary Material for: Postresection Period-Specific Hazard of Recurrence as a Framework for Surveillance Strategy in Patients with Hepatocellular Carcinoma: A Multicenter Out... by Kim H.I. (11448466)

“…To set an evidence-based timetable for postoperative surveillance, we investigated the annual hazard rate of recurrence through postoperative year 10 in patients undergoing hepatectomy for HCC, and the clinical and morphological phenotypes associated with early versus late recurrence. <b><i>Results:</i></b> The estimated hazard rate for recurrence peaked during year 0–1 (21.7%), with a subsequent gradual decrease through 5 years, followed by stabilization at <7.0% until year 10, except in the case of cirrhotics, who had a rate of 10.5% during year 4–5. …”

The Response of the Alpine Dwarf Shrub <i>Salix herbacea</i> to Altered Snowmelt Timing: Lessons from a Multi-Site Transplant Experiment by Janosch Sedlacek (301844)

“…However, in the long term, reduction in leaf size and flowering, a longer phenological development time and increased exposure to damage may decrease overall performance of <i>S</i>. <i>herbacea</i> under earlier snowmelt.…”

Dimer Formation Enhances Structural Differences between Amyloid β-Protein (1–40) and (1–42): An Explicit-Solvent Molecular Dynamics Study by Bogdan Barz (173139)

“…A dimers were characterized by an increased flexibility in the N-terminal region D1-R5 and a larger solvent exposure of charged amino acids relative to A dimers. …”

Pairing sensitive silencing between Class A alleles reflects a direct role for PcG proteins in regulating <i>eya</i>. by Katherine Tian (768002)

“…Consistent with pairing-sensitive silencing, decreased eye development is observed when <i>eya</i>^<i>cs</i> is placed in <i>trans</i> to other Class A alleles relative to <i>eya</i>^<i>cs</i> homozygotes, and the decrease is disrupted by the <i>eya</i>^<i>2</i> rearrangement ETD2.2 (compare column 4 to column 5). …”

Table1_Cognitive performance in ISS astronauts on 6-month low earth orbit missions.docx by Sheena I. Dev (20293434)

“…We provide descriptive statistics of pre-flight cognitive performance from 25 astronauts, the largest published preliminary normative database of its kind to date, to help identify significant performance decrements in future samples.…”

Image1_Cognitive performance in ISS astronauts on 6-month low earth orbit missions.pdf by Sheena I. Dev (20293434)

“…We provide descriptive statistics of pre-flight cognitive performance from 25 astronauts, the largest published preliminary normative database of its kind to date, to help identify significant performance decrements in future samples.…”

Association of methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms (C677T and A1298C) with thyroid dysfunction: A meta-analysis and trial sequential analysis by Rui Yang (293531)

“…The MTHFR A1298C polymorphism was related to a decreased risk of hypothyroidism (C vs. …”

Association of methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms (C677T and A1298C) with thyroid dysfunction: A meta-analysis and trial sequential analysis by Rui Yang (293531)

“…The MTHFR A1298C polymorphism was related to a decreased risk of hypothyroidism (C vs. …”

Cer1 gRNA persistence after RNAi. by Bing Sun (44691)

“…<i>gRNA(RNAi)</i> for 24 hrs caused a moderate decrease in cytoplasmic gRNA compared to control gonads, but <i>gRNA(RNAi)</i> for 48 hrs caused a much larger relative decrease. …”

After-suppression depends on local network properties. by Michael Avery (2865419)

Reliable high-PAP-1-loaded polymeric micelles for cancer therapy: preparation, characterization, and evaluation of anti-tumor efficacy by Fang Ye (112854)

“…Molecular simulations revealed that PAE’s tertiary amine protonation affected the self-assembly process, modifying hydrophobicity and resulting in larger, loosely packed particles. Furthermore, compared to free PAP-1 or PAP-1 combined with MDR inhibitors, PAP-1-loaded micelles significantly enhanced cytotoxicity and apoptosis induction in Jurkat and B16F10 cells, through mechanisms involving decreased mitochondrial membrane potential and elevated caspase-3 activity. …”

Meta-analyses of the association of <i>G6PC2</i> allele variants with elevated fasting glucose and type 2 diabetes by Yuanyuan Shi (563992)

“…However, the G-allele of rs560887 in Caucasians under the additive model and the C-allele of rs16856187 under the allele and dominant models were associated with a decreased risk of T2D (OR (95% CI) = 0.964 (0.947, 0.981), <i>p</i> = 0.570e-4; OR (95% CI) = 0.892 (0.832, 0.956), <i>p</i> = 0.001; and OR (95% CI) = 0.923(0.892, 0.955), <i>p</i> = 5.301e-6, respectively).…”

Data_Sheet_1_Exploratory analysis of one versus two-day intermittent fasting protocols on the gut microbiome and plasma metabolome in adults with overweight/obesity.docx by Alex E. Mohr (12033735)

“…Participants (n = 20) were randomly assigned to either a diet consisting of one fasting day (total of 36 h) and six low-calorie P days per week (IF1-P, n = 10) or two fasting days (60 h total) and five low-calorie P days per week (IF2-P, n = 10). …”

An Epoxyisoprostane Is a Major Regulator of Endothelial Cell Function by Wei Zhong (284774)

“…EI strongly inhibits the production of MCP-1, a major monocyte chemotactic factor, and either decreases or minimally increases the levels of 10 proinflammatory molecules increased by PEIPC. …”

Supplementary Material for: Ruthenium-106 plaque brachytherapy for circumscribed choroidal hemangioma: A case series and review of literature. by Swaify I.Y. (17741178)

“…Largest tumor base diameter also decreased significantly from 9.13±2.68 mm to 4.65±3.75 mm (p-value 0.05). …”

Data_Sheet_1_The Rapid Forgetting of Faces.docx by Dana Krill (5565287)

“…In contrast to the effect of retention interval (i.e., forgetting), face inversion led to larger errors that were mainly associated with decreased precision of recall. …”

Longitudinal microbiome analysis of single donor fecal microbiota transplantation in patients with recurrent <i>Clostridium difficile</i> infection and/or ulcerative colitis by Michael Mintz (4811274)

“…<i>difficile</i> infections (UC-only).</p><p>Method</p><p>V3V4 Illumina 16S ribosomal RNA (rRNA) gene sequencing was performed on the pre-FMT, 1-week post-FMT, and 3-months post-FMT recipient fecal samples along with those collected from the healthy donors. …”