The effect of hydroxychloroquine on lupus erythematosus-like skin lesions in MRL/lpr mice by Tatsuya Shimomatsu (1545943)

“…<p><i>Objectives</i>: To evaluate the effect and safety of hydroxychloroquine (HCQ) on lupus erythematosus (LE)-like skin lesions in the MRL/lpr mouse, a model for systemic LE (SLE).</p> <p><i>Methods</i>: We divided the MRL/lpr mice into three groups that were given: (1) drinking water, (2) HCQ at a dose of 4 mg/kg/d, or (3) HCQ at a dose of 40 mg/kg/d. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…However, no secosteroidal silicon-containing VDR ligands have been developed. Here we report the design, synthesis, and biological activity of six analogues of the natural hormone 1,25-dihydroxyvitamin D3 (1,25D₃), which incorporate a silicon atom as a side chain-C25 isostere. …”

Protein Kinase C-Dependent Signaling Controls the Midgut Epithelial Barrier to Malaria Parasite Infection in Anopheline Mosquitoes by Nazzy Pakpour (245650)

“…PKC inhibition did, however, significantly increase midgut barrier integrity and decrease development of <i>P. falciparum</i> oocysts in <i>A. stephensi</i>, suggesting that PKC-dependent signaling is a negative regulator of epithelial barrier function and a potential new target for transmission-blocking strategies.…”

Table_1_Volumetric analysis of the aging auditory pathway using high resolution magnetic resonance histology.XLSX by Eric Y. Du (14097132)

“…Six of the 12 regions of interests demonstrated a significant age-related effect. …”

Correlation Analysis. by Christof Kuhbandner (282992)

“…<p>(A) Correlation between amount of forgetting (i.e., decrease in memory performance for nontested questions relative to memory performance for the same questions when used as control questions; larger values indicate a larger amount of forgetting) and post-manipulation valence score. …”

Data_Sheet_1_Effect of Land Use History on Biodiversity of Pine Plantations.docx by Sandra V. Uribe (8575152)

“…Using aerial photographs and satellite images encompassing a period of six decades, we classified 108 4-ha sampling units into native forests, and mature (17–20 year) pine plantations of first, second, and third rotation, of either forest or agricultural origin. …”

Table_1_Estimation of Cerebral Hemodynamics and Oxygenation During Various Intensities of Rowing Exercise: An NIRS Study.docx by Mikio Hiura (12176669)

“…At exhaustion, the cerebral metabolic rate for oxygen is maintained despite a decrease in ScO₂.</p>…”

DataSheet_1_Pneumonia in the first week after polytrauma is associated with reduced blood levels of soluble herpes virus entry mediator.pdf by Noah Schaefer (17693946)

“…</p>Materials and methods<p>Patients were studied from day two to six after admission to a surgical intensive care unit (ICU). …”

Table 1_Environmental enrichment affects immunity and reduces disease severity in pigs after co-infection, with stronger effects when applied from birth than from weaning.docx by Brigitte G. C. de Bruijn (20401226)

“…In conclusion, enriched housing from birth reduced disease severity to co-infection with PRRSV and A. pleuropneumoniae. Enrichment applied after weaning also seemed to decrease the pathological lung deviations to the co-infection as compared to barren housed pigs, but to a much lower extent.…”

Evolution of Canada’s Boreal Forest Spatial Patterns as Seen from Space by Paul D. Pickell (3159126)

“…Rapidly changing landscapes, defined as the 90^th percentile of forest cover change, were among the most forested initially and were characterized by four times greater decrease in largest forest patch index, three times greater increase in forest edge density, and four times greater decrease in core forest cover compared with all 50,000 ha landscapes. …”

Impact of a single customer. by Chengyuan Han (7901234)

“…With the new customer production increases and the production costs per unit decrease by <i>aD</i> (economies of scale). This compensates larger transport costs for nodes further away from the supplier. …”

Data_Sheet_1_The effect of interictal epileptic discharges and following spindles on motor sequence learning in epilepsy patients.docx by Toshiki Okadome (14097309)

“…The changes in learning effect of the patient group during ASM withdrawal were not correlated with changes in sleep duration or IED density; however, they were significantly negatively correlated with changes in IED-coupled spindle density.</p>Conclusion<p>We found that the increase of IED-coupled spindles correlated with the decrease of sleep-dependent learning effects of procedural memory. …”

Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats by Patricia Alegre (7888787)

“…We also observed increased myocardial activity of b-hydroxyacyl coenzyme-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, complex I, complex II and ATP synthase in the A group as well as lower activity of the lactate dehydrogenase and phosphofructokinase enzymes. …”

Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats by Patricia Alegre (7888787)

“…We also observed increased myocardial activity of b-hydroxyacyl coenzyme-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, complex I, complex II and ATP synthase in the A group as well as lower activity of the lactate dehydrogenase and phosphofructokinase enzymes. …”

Use of an Enactive Insole for Reducing the Risk of Falling on Different Types of Soil Using Vibrotactile Cueing for the Elderly by Martin J. -D. Otis (3108411)

“…</p><p>Conclusions</p><p>Firstly, this paper demonstrates the feasibility of reducing the risk of falling while walking on different types of soil using vibrotactile cueing. We found a significant difference and a significant decrease in the computed risks of falling for most of types of soil especially for deformable soils which can lead to fall. …”