Carbenoxolone Disodium Treatment for Canine Pituitary-Dependent Hyperadrenocorticism by Takahiro Teshima (782117)

“…In some animal species, including dogs, the aberrant expression of 11β-hydroxysteroid dehydrogenase (11HSD), a cortisol metabolic enzyme, is observed in corticotroph tumors. We previously reported that carbenoxolone (CBX), an inhibitor of 11HSD, suppressed ACTH secretion from the pituitary gland, and decreased cortisol concentrations in healthy dogs. …”

DataSheet_1_Metabolite Changes After Metabolic Surgery – Associations to Parameters Reflecting Glucose Homeostasis and Lipid Levels.docx by Sofie Ahlin (351308)

“…The branched chain amino acids displayed a significant decrease together with a decrease in BCAT1 adipose tissue mRNA levels. …”

Double Hybrid Functionals and the Π‑System Bond Length Alternation Challenge: Rivaling Accuracy of Post-HF Methods by Michael Wykes (1359216)

“…Predicting accurate bond length alternations (BLAs) in long conjugated oligomers has been a significant challenge for electronic-structure methods for many decades, made particularly important by the close relationships between BLA and the rich optoelectronic properties of π-delocalized systems. Here, we test the accuracy of recently developed, and increasingly popular, double hybrid (DH) functionals, positioned at the top of <i>Jacobs Ladder</i> of DFT methods of increasing sophistication, computational cost, and accuracy, due to incorporation of MP2 correlation energy. …”

Sequence gaps exclusive to both Archaea and Microsporidia 16S rRNAs. by Chaitanya Muralidhara (223748)

“…(<i>a</i>) The 100 gaps conserved in both the Archaea and Microsporidia map to the entire substructures I–III in the secondary structure model of the bacterium <i>E. coli</i> <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Cannone1" target="_blank">[14]</a>. …”

S2 Data - by Idika E. Okorie (11350612)

“…<div><p>We carry out a time series analysis on the yearly crop yield data in six east African countries (Burundi, Kenya, Somalia, Tanzania, Uganda and Rwanda) using the autoregressive integrated moving average (ARIMA) model. …”

S3 Data - by Idika E. Okorie (11350612)

“…<div><p>We carry out a time series analysis on the yearly crop yield data in six east African countries (Burundi, Kenya, Somalia, Tanzania, Uganda and Rwanda) using the autoregressive integrated moving average (ARIMA) model. …”

S6 Data - by Idika E. Okorie (11350612)

“…<div><p>We carry out a time series analysis on the yearly crop yield data in six east African countries (Burundi, Kenya, Somalia, Tanzania, Uganda and Rwanda) using the autoregressive integrated moving average (ARIMA) model. …”

S7 Data - by Idika E. Okorie (11350612)

“…<div><p>We carry out a time series analysis on the yearly crop yield data in six east African countries (Burundi, Kenya, Somalia, Tanzania, Uganda and Rwanda) using the autoregressive integrated moving average (ARIMA) model. …”

S8 Data - by Idika E. Okorie (11350612)

“…<div><p>We carry out a time series analysis on the yearly crop yield data in six east African countries (Burundi, Kenya, Somalia, Tanzania, Uganda and Rwanda) using the autoregressive integrated moving average (ARIMA) model. …”

S5 Data - by Idika E. Okorie (11350612)

“…<div><p>We carry out a time series analysis on the yearly crop yield data in six east African countries (Burundi, Kenya, Somalia, Tanzania, Uganda and Rwanda) using the autoregressive integrated moving average (ARIMA) model. …”

S4 Data - by Idika E. Okorie (11350612)

“…<div><p>We carry out a time series analysis on the yearly crop yield data in six east African countries (Burundi, Kenya, Somalia, Tanzania, Uganda and Rwanda) using the autoregressive integrated moving average (ARIMA) model. …”

S1 Data - by Idika E. Okorie (11350612)

“…<div><p>We carry out a time series analysis on the yearly crop yield data in six east African countries (Burundi, Kenya, Somalia, Tanzania, Uganda and Rwanda) using the autoregressive integrated moving average (ARIMA) model. …”

S1 File - by Idika E. Okorie (11350612)

“…<div><p>We carry out a time series analysis on the yearly crop yield data in six east African countries (Burundi, Kenya, Somalia, Tanzania, Uganda and Rwanda) using the autoregressive integrated moving average (ARIMA) model. …”

Dynamics and structural stability effects of germline <i>PTEN</i> mutations associated with cancer versus autism phenotypes by Iris Nira Smith (5215259)

“…We demonstrate structural stability changes where all six cancer-associated mutations showed a global decrease in structural stability and increased dynamics across the domain interface with a proclivity to unfold, mediating a closed (inactive) active site. …”

Calcium levels in PC12 cells exposed to SMF, the A_2AR agonist CGS21680 or antagonist ZM241385. by Zhiyun Wang (360002)

“…Cells treated with 1.0 µM CGS21680 experienced decreased Ca²⁺ release compared to control cells while co-treatment of the cells with this agonist and either 1.0 µM ZM241385 or SMF attenuated the CGS21680-induced decrease (<i>p</i> values for each comparison are shown on the chart for n = 3 independent experiments).…”

Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome by Ingrid M. M. Schellens (377152)

“…<div><p>The cytotoxic T cell (CTL) response is determined by the peptide repertoire presented by the HLA class I molecules of an individual. We performed an in-depth analysis of the peptide repertoire presented by a broad panel of common HLA class I molecules on four B lymphoblastoid cell-lines (BLCL). …”

Subsample analysis of supply-side explanations. by Santiago Carbo-Valverde (9575368)

“…<p>Fig 18 reports the relative importance—measured by mean decrease in accuracy—of those variables with the largest predictive power for the adoption of online banking by banks’ characteristics: size (large banks’ customers—Santander, BBVA, and CaixaBank—vs other banks’ customers) and branch closure (customers whose main bank closed at least one branch in their province vs customers whose main bank has not closed any branch in their province). …”

Changes in Network and Node Properties Associated with Increasing Vulnerability. by Christine Moore (517762)

“…(b) Number of components (number of independent/isolated sub groups) – A decrease in the number of isolated groups increases the reachability of any random node (c) Giant Component (largest independent/isolated sub group) – if the largest component contracts infection, this infection can spread further through the Giant Component compared to smaller, more isolated components which will make the whole network more vulnerable. …”

Properties of evolved FUS PLD. by Simon M. Lichtinger (11326846)

“…In genetic-algorithm runs which increase <i>T</i>_c, hydrophobic amino acids become favoured, whilst the converse holds for genetic-algorithm runs which decrease <i>T</i>_c. …”

Increased Response to Glutamate in Small Diameter Dorsal Root Ganglion Neurons after Sciatic Nerve Injury by Kerui Gong (429477)

“…We recorded neuronal responses from the <i>ex-vivo</i> preparations of the dorsal root ganglia (DRG) one week following a chronic constriction injury (CCI) of the sciatic nerve in adult rats. …”