Identification of narciclasine as a novel NRF2 inhibitor by Hoang Hai Ngo (20564072)

“…<p>Cancer genome sequencing studies have identified somatic mutations in the KEAP1/NRF2 pathway. In an effort to identify novel NRF2 small molecule inhibitor(s), we have screened a natural compound library comprising 1330 chemicals in A549-ARE-GFP-luciferase cells and identified that narciclasine significantly inhibits NRF2-dependent luciferase activity. …”

Data Sheet 1_Dose-dependent effects of biochar amendment on early rice seedling growth and nursery substrate properties in Southern China.pdf by Liming Chen (113761)

“…Conversely, the 40% and 50% treatments had inhibitory effects, resulting in significant reductions in seedling leaf length, stem base width (decreased by 24.9%), dry weight, and leaf area. Root fresh weight also decreased by 11.9%–17.1%. …”

Table 1_Cannabidiol reduces synaptic strength and neuronal firing in layer V pyramidal neurons of the human cortex with drug-resistant epilepsy.docx by Vladimir A. Martinez-Rojas (21758372)

“…At the cellular level, whole-cell patch-clamp recordings showed that CBD decreased the excitability of layer V pyramidal neurons, as evidenced by changes in the somatic input resistance, the membrane time constant, the hyperpolarization-induced “sag” conductance, the rheobase current needed to elicit an action potential, and the firing discharge in response to depolarizing current steps. …”

JAK/STAT signaling promotes high global translation rates in CySCs. by Ruoxu Wang (9312306)

“…(C, C′) A wild-type testis showing highest OPP in CySCs adjacent to the hub and decreasing OPP levels with increasing distance from the hub. …”

Data Sheet 1_Recognition and localization of ratoon rice rolled stubble rows based on monocular vision and model fusion.docx by Yuanrui Li (4156645)

“…</p>Methods<p>In order to realize automatic navigation of the righting machine, a method of fusing an instance segmentation model and a monocular depth prediction model was used to realize monocular localization of the rolled rice stubble rows in this study.…”

Supplementary file 1_Early life microbiome disbalance impacts neuroendocrine outcomes in pre-pubertal mice in a sexually dimorphic manner.zip by Bistra B. Nankova (21576839)

“…Maternal antibiotics during nursing caused: (1) microbial dysbiosis in the offspring as evident by markedly enlarged ceca, no detectable by-products of bacterial fermentation (sp. SCFA) and dramatic changes in microbial composition, diversity (reduced - alpha Chao1and beta Bray-Curtis, as compared to their respective controls) and predictive metabolic activity; (2) alteration in the transcriptional signature of the adrenal medullae and attenuated peripheral stress responses in male offspring, associated with gap junction signaling pathways; (3) increased anxiety-like testing metrics, and decreased locomotor activity; all in a sexually dimorphic manner.…”

data-raw.xls by Jinlei Zhu (19952964)

“…Sap flow velocity and daily sap flow accumulation increased at 50% stumping but decreased at 75% and 100% stumping. Stumping altered the relationships between sap flow velocity and meteorological factors, with the correlation coefficient between these variables decreasing as the degree of stumping increased. …”

Scale and environmental data for the analysis of year class growth of coregonids from Lake Starnberg by Maxim Teichert (20796416)

“…During the observed period, phosphorus concentrations decreased, indicating reduced nutrient availability, whereas spring temperatures showed no significant long-term trend. …”

Table 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.docx by Nourhen Agrebi (14151222)

“…Background<p>Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations complicate diagnosis and management.…”

Data Sheet 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.pdf by Nourhen Agrebi (14151222)

“…Background<p>Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations complicate diagnosis and management.…”

Supplemental Tables for "Hypoxia-inducible factor 1alpha is required to establish the larval glycolytic program in <i>Drosophila melanogaster</i>" by Jason Tennessen (18762937)

“…<p dir="ltr"><b>Objectives:</b> The rapid growth that occurs during <i>Drosophila</i> larval development requires a dramatic rewiring of central carbon metabolism to support biosynthesis. …”

Table 1_Early detection of retinal and choroidal microvascular impairments in diabetic patients with myopia.docx by Yufei Wu (3625967)

“…The AI-driven analysis revealed that decreased CVI and CT were significantly associated with age and spherical equivalent (SE), highlighting the utility of automated algorithms in identifying early microvascular impairments.…”

Data Sheet 1_Case Report: Late diagnosis of McCune-Albright with severe kyphoscoliosis, acromegaly and tertiary hyperparathyroidism.pdf by Anna Bogusławska (20293545)

“…<p>McCune–Albright syndrome (MAS) is a rare genetic disorder caused by somatic activating variants of the GNAS gene. Due to the mosaic state of the variants, the clinical presentation of MAS varies widely depending on the tissues involved. …”

Data Sheet 1_Influence of water temperature on feed intake, appetite control, and energy allocation in Atlantic salmon (Salmo salar) post-smolt.pdf by F. Lai (17234491)

“…In this study, feed intake, feed efficiency, somatic indices and growth were examined in Atlantic salmon post-smolts (ca. 200 g) acclimated to either 8°C, 12°C or 15°C for 8 weeks. …”

Table 1_A daily positive work reflection intervention for psychological distress among Chinese nurses: a pilot randomized controlled trial.docx by Li Zhang (8200)

“…</p>Conclusions<p>Results suggest that a daily positive work reflection intervention is a feasible and promising intervention for decreasing Chinese nurses' psychological distress. The study used a convenience sample which led to a concern of external generalizability, and the study had limited evaluation of long-term change.…”

Data Sheet 1_Effect of cultivation feed diet using local food processing by-products on the growth and flavor factor in the Malabar grouper Epinephelus malabaricus.docx by Makoto Takahashi (386772)

“…Growth performance, liver somatic index, insulin-like growth factor 1 (IGF-1) gene expression, and muscle taste-related components were analyzed.…”

Data Sheet 1_Thalamic functional dysconnectivity in patients with left-hemisphere chronic capsular and pontine stroke.pdf by Jun Guo (85069)

“…</p>Results<p>The ipsilesional thalamus of CS patients had abnormally decreased FC with widespread cognitive-related areas while increased FC with visual- and somatic-motor areas. …”

Data Sheet 1_Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease.zip by Xi Luo (361139)

“…Both PD models predicted reduced uptake of lysine and lactate, indicating coordinated metabolic processes between these components. In contrast, decreased methionine and urea uptake was exclusively predicted in the synaptic PD model, while decreased histidine and glyceric acid uptake was exclusive to the non-synaptic PD model. …”

Table 1_Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease.docx by Xi Luo (361139)

“…Both PD models predicted reduced uptake of lysine and lactate, indicating coordinated metabolic processes between these components. In contrast, decreased methionine and urea uptake was exclusively predicted in the synaptic PD model, while decreased histidine and glyceric acid uptake was exclusive to the non-synaptic PD model. …”

Image 1_Cellular immune responses of bovine polymorphonuclear neutrophils to Calicophoron daubneyi.jpeg by Liliana M. R. Silva (9291971)

“…Following excystation, juvenile flukes penetrate the small intestinal mucosa and migrate into the rumen where adults mature. Throughout the somatic migration, juveniles come across different microenvironments and tissues and encounter host leukocytes. …”