Fig 26 - حسب Piotr Popik (292215)

Fig 26 - حسب Zhezhe Zhang (19704587)

Loss of RBM-26 causes mitochondria dysfunction in PLM. حسب Tamjid A. Chowdhury (14149846)

Loss of RBM-26 function causes a reduction in the density of mitochondria in the PLM axon. حسب Tamjid A. Chowdhury (14149846)

Interleaved increasing (uneven numbered tones) and decreasing (even numbered tones) series of tones, ISI 26.6ms. حسب Nathanael Larigaldie (21703267)

Mutations in <i>rbm-26</i> cause axon degeneration and axon overlap defects. حسب Tamjid A. Chowdhury (14149846)

Expression of RBM-26 is disrupted by P80L and L13V missense mutations. حسب Tamjid A. Chowdhury (14149846)

RBM-26 binds to the <i>mals-1</i> mRNA and negatively regulates its expression. حسب Tamjid A. Chowdhury (14149846)

Histogram of number of drugs with (a) increased and (b) decreased usage within 12 months. حسب Nguyen Thach (20347852)

Loss of MALS-1 function suppresses the mitochondrial and axon degeneration phenotypes that are caused by loss of RBM-26 function. حسب Tamjid A. Chowdhury (14149846)

"…(D) Loss of RBM-26 protein expression causes a decrease in mitoribosome expression, which was assayed with the MitoRibo-Tag system consisting of the MRPL-58 mitoribosomal protein tagged at its C-terminus with 3XFLAG (MRPL-58::3XFLAG). …"

RBM-26 is expressed in the PLM and functions within neurons to protect against axon degeneration and prevent axon overlap defects. حسب Tamjid A. Chowdhury (14149846)

Histograms of the extent of the (a) increase and (b) decrease by the difference in categorical usage within 12 months for all drugs. حسب Nguyen Thach (20347852)

Underlying data for the main figures. حسب Tamjid A. Chowdhury (14149846)

"…Autism-associated missense variants in RBM-26 cause a sharp decrease in RBM-26 protein expression along with defects in axon overlap and axon degeneration that occurs during larval development. …"

Underlying data for the supplemental figures. حسب Tamjid A. Chowdhury (14149846)

"…Autism-associated missense variants in RBM-26 cause a sharp decrease in RBM-26 protein expression along with defects in axon overlap and axon degeneration that occurs during larval development. …"

Overexpression of MALS-1 reduces mitochondria in the PLM axon and causes axon degeneration and axon overlap defects. حسب Tamjid A. Chowdhury (14149846)

"…<p>(A–C) Overexpressed MALS-1::Scarlet protein colocalizes with mitochondria. …"

BrdU incorporation is elevated in clrn1-/- zebrafish at 4 mpf and decreases with age. حسب Hannah J. T. Nonarath (20861735)

CaMKKβ is involved in ST2-104-regulated decrease in autophagy. حسب Yingshi Ji (9013004)

CaMKKβ contributes to the decrease in apoptosis conferred by ST2-104. حسب Yingshi Ji (9013004)

SUMO-dependent disruption of SET-26 complex formation. حسب Cátia A. Carvalho (20513858)

"…<p>(<b>A</b>) Schematic representation of the AP-MS strategy to isolate SET-26::GFP in WT versus an excessive sumoylation background; 3 biological replicates. …"

Repetitive stress induces a decrease in sound-evoked activity. حسب Ghattas Bisharat (20706928)

"…Activity rates decreased during repeated stress compared to baseline (2-way ANOVA, condition F = 185.6, <i>p</i> = 4.8 × 10⁻⁴², condition: intensity interaction F = 10.37, <i>p</i> = 9.3 × 10⁻²¹, nested ANOVA (mouse nested within session), condition F = 174, <i>p</i> = 1.5 × 10⁻³⁹, condition: intensity interaction F = 12.7, <i>p</i> = 2 × 10⁻²⁶, post hoc for each level baseline versus repetitive stress <i>p</i> < 0.01 for all levels above 50 dB, all Bonferroni corrected). …"