Showing 1 - 20 results of 602 for search '(( traits ((larger decrease) OR (marked decrease)) ) OR ( via ((nf decrease) OR (mean decrease)) ))', query time: 0.50s Refine Results
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    Data Sheet 1_The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-κB pathway.docx by Lu Wang (45927)

    Published 2025
    “…</p>Discussion<p>Our findings reveal that R-2HG specifically inhibits microglial inflammatory activation by suppressing the FTO/NF-κB signaling pathway, leading to decreased IL-6 production. …”
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    Polysaccharides from Black Mulberry Attenuate Colitis through Gut Microbiota Mediated TNF-α/pNF-κB/ICAM‑1 Signaling Pathway by Li-Tao Yi (13780216)

    Published 2025
    “…., which correlated with elevated short-chain fatty acids (SCFAs) and decreased pro-inflammatory markers. Colonic RNA sequencing revealed the role of PBM in attenuating colitis via the TNF-α/NF-κB/ICAM-1 signaling pathway. …”
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    Data Sheet 1_Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway.docx by Yumei Rong (11589031)

    Published 2025
    “…</p>Discussion<p>In summary, our data suggested that LD<sub>4</sub>-PDT could inhibit DSS-induced UC in rats via the NF-κB signaling pathway, indicating its potential as a novel photosensitizer for the treatment of UC.…”
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    Image 1_Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis.jpeg by Heng Deng (4402264)

    Published 2025
    “…</p>Results<p>ZQG treatment dose-dependently (1) ameliorated colonic mucosal damage, reducing histological scores by 52% compared to that in the model group, (2) modulated macrophage polarization by increasing the M2 phenotype (CD206<sup>+</sup> cells, 3.25-fold increase) while decreasing M1 macrophages (CD86<sup>+</sup> cells, 70% reduction), (3) upregulated PPAR-γ expression (2.0-fold increase) while suppressing NF-κB activation (43% decrease in p-NF-κB) and STAT1 signaling (48% and 40% reductions in protein and mRNA levels, respectively), and (4) rebalanced inflammatory cytokines, with 55%–62% reductions in TNF-α, IL-6, and IL-1β and 185%–210% increases in IL-10 and IL-4. …”
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