The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication by Peili Hou (4737219)

“…However, how SARS-CoV-2 mediates the subversion of the macroautophagy/autophagy pathway remains largely unclear. In this study, we demonstrate that overexpression of the SARS-CoV-2 ORF7a protein activates LC3-II and leads to the accumulation of autophagosomes in multiple cell lines, while knockdown of the viral <i>ORF7a</i> gene via shRNAs targeting <i>ORF7a</i> sgRNA during SARS-CoV-2 infection decreased autophagy levels. …”

Model. by Anne-Laure Pauleau (7430555)

“…Cells that have a relative large pool of CENP-A at centromeres go through mitosis faster. …”

Sectors exporting a large share of their output to customers directly affected by a post-Brexit no-trade-deal event are particularly prone to production losses. by Leonie Wenz (9339107)

Decrease in apoptosis in the ischemic myocardium. by Laura A. Scrimgeour (9367459)

“…<p>There is an increase seen in JNK, pBAD, and pBAD/BAD with a decrease in pBCL-2, pBCL-2/BCL-2, and Caspase 3. …”

MCP-1-deficiency decreased CD11c-expressing cells via impairing the production of ROS and decreased activation of PLCγ2, Akt, and ERK upon M-CSF stimulation in BMM. by Woon-Ki Kim (447798)

Impact of large choroidal vessels (LCV) and topographical orientation on percentage of flow deficit (FD%) values. by Valentin Hacker (9956024)

Impaired Functions of Macrophage from Cystic Fibrosis Patients: CD11b, TLR-5 Decrease and sCD14, Inflammatory Cytokines Increase by Karin Simonin-Le Jeune (464354)

“…Macrophages may however play a significant role in the initiating stages of this disease, <i>via</i> an inability to act as a suppressor cell. …”

PACAP Protects Adult Neural Stem Cells from the Neurotoxic Effect of Ketamine Associated with Decreased Apoptosis, ER Stress and mTOR Pathway Activation by Shiva Mansouri (2838086)

“…The neuroprotective effect via PAC-1 activation suggests a potentially novel pharmacological target for the treatment of schizophrenia, <i>via</i> neurogenesis normalization.…”

No discernible effect of high-dose 5-HT_2AR blockade on error rates in the reward-size task. by Yukiko Hori (299784)

VEGF-A knockdown via RNAi in mouse endothelial cells and cardiomyocytes in a doxycycline-regulatable fashion. by Mari Merentie (4781907)

Inhibition of PI4KIIIα by AL-9 induces the formation of large NS5A clusters. by Annalisa Bianco (178719)

Cell-to-cell mtDNA variability for larger mtDNA populations. by Robert C. Glastad (10692277)

“…The three columns for each panel give decreasing network heterogeneity, expressed via different seed numbers, 4, 16 and 64 (more seed points give a more homogeneous network). …”

Differences between performance in large workspace (LSW) and small workspace (SWS) for flexion/extension (A), abduction/adduction (B) and pronation/supination. by Francesca Marini (12576)

APAP bioactivation is decreased in fructose-fed mice. by Sungjoon Cho (4385851)

Average time-to-next-treatment (TTNT) analysis measured in days of large cell transformation (LCT) versus non-large cell transformation (NLCT) groups. by Neil K. Jairath (13237338)

The Reversible Increase in Tight Junction Permeability Induced by Capsaicin Is Mediated via Cofilin-Actin Cytoskeletal Dynamics and Decreased Level of Occludin by Tomoko Shiobara (486327)

“…No change in TJ protein localization was observed upon exposure to capsaicin, but the amount of occludin was decreased significantly. In addition, cosedimentation analyses suggested a decrease in the interactions forming TJ, thereby weakening TJ tightness. …”

Data_Sheet_1_Decreasing the Surgical Errors by Neurostimulation of Primary Motor Cortex and the Associated Brain Activation via Neuroimaging.PDF by Yuanyuan Gao (448666)

“…<p>Acquisition of fine motor skills is a time-consuming process as it is based on learning via frequent repetitions. …”

Effect of 5-HT depletion via pCPA on incentive. by Yukiko Hori (299784)

Inhibition of PI3K activity decreases uptake of Opa_CEA-expressing gonococci via CEACAM1. by Maike Voges (154488)

Tet inhibits RCC migration and invasion <i>via</i> decreasing Akt, NF-κB and MMP-9 expression. by Shurui Chen (3833443)