A Mitogen-Activated Protein Kinase Tmk3 Participates in High Osmolarity Resistance, Cell Wall Integrity Maintenance and Cellulase Production Regulation in <i>Trichoderma reesei</i> by Mingyu Wang (103886)

“…We also showed significant downregulation of genes encoding chitin synthases and a β-1,3-glucan synthase, decreased chitin content, ‘budded’ hyphal appearance typical to cell wall defective strains, and increased sensitivity to calcofluor white/Congo red in the <i>tmk3</i> deficient strain, suggesting Tmk3 is involved in cell wall integrity maintenance in <i>T. reesei</i>. …”

PRC1 affects Pol II occupancy and function at both silenced and active genes. by Cheri A. Schaaf (144616)

“…<p>(<b>A</b>) The change in total Pol II ChIP signal (ΔRpb3, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003560#pgen.1003560.s007" target="_blank">Figure S7</a> method 1) in the bodies of the 13,132 genes measured for mRNA levels (X axis) plotted versus the change in elongating phosphorylated Pol II (ΔSer2P Pol II) (Y axis) caused by Ph (PRC1) depletion. …”

Observed and predicted human MPX occurrence. by Henri A. Thomassen (237544)

“…For areas shown in red, there has been a large increase in the human population since 1990 and further growth is forecast in the imminent future. …”

SalK/SalR, a Two-Component Signal Transduction System, Is Essential for Full Virulence of Highly Invasive <em>Streptococcus suis</em> Serotype 2 by Ming Li (91180)

“…<div><h3>Background</h3><p><em>Streptococcus suis</em> serotype 2 (<em>S. suis</em> 2, SS2) has evolved into a highly infectious entity, which caused the two recent large-scale outbreaks of human SS2 epidemic in China, and is characterized by a toxic shock-like syndrome. …”

The effect of early versus late initiation of renal replacement therapy in patients with acute kidney injury: A meta-analysis with trial sequential analysis of randomized controlle... by Yan-mei Feng (3854533)

“…Therefore, well-designed, large RCTs are needed.</p></div>…”

Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes <em>Cdkn1a</em> and <em>Cdkn1b</em> by Timo H-W. Lüdtke (103071)

“…Deletion of both <em>Cdkn1a</em> and <em>Cdkn1b</em> rescued, to a large degree, the growth deficits of <em>Tbx2</em>-deficient lungs. …”

Results of sensitivity analyses. by Sean A. Rands (199852)

“…A large positive median value of the coefficient shows that final ornament size/start period increased greatly as the size of the variable being investigated was increased (and a large negative value showed that final ornament size/start period decreased as the variable was increased). …”

Poly- and Perfluoroalkyl Substances in Municipal Wastewater Treatment Plants in the United States: Seasonal Patterns and Meta-Analysis of Long-Term Trends and Average Concentration... by Kyle A. Thompson (3196548)

“…The occurrence of individual PFAS may vary temporally; for example, perfluoropentanoic acid correlated weakly with seasonal temperatures at a site in Virginia. Wastewater effluent PFOA concentrations decreased at a site in Nevada from 2012 to February 2020 but appeared to increase during the COVID-19 pandemic. …”

Image_1_The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.TIF by Seon-yeong Lee (6067604)

“…STA21 significantly decreased expression of these proinflammatory molecules via inhibition of STAT3 activity but increased gene expression of molecules related to migration potential and immunomodulation in OA-MSCs. …”

Acute Podocyte Vascular Endothelial Growth Factor (VEGF-A) Knockdown Disrupts alpha_Vbeta₃ Integrin Signaling in the Glomerulus by Delma Veron (151378)

“…Collectively, these studies indicate that podocyte VEGF-A regulates alpha_Vbeta₃ integrin signaling in the glomerulus, and that podocyte VEGF knockdown disrupts alpha_Vbeta₃ integrin activity via decreased VEGFR2 signaling, thereby damaging the three layers of the glomerular filtration barrier, causing proteinuria and acute renal failure.…”

Image_1_The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.TIF by Seon-yeong Lee (6067604)

“…STA21 significantly decreased expression of these proinflammatory molecules via inhibition of STAT3 activity but increased gene expression of molecules related to migration potential and immunomodulation in OA-MSCs. …”

Image_2_The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.TIF by Seon-yeong Lee (6067604)

“…STA21 significantly decreased expression of these proinflammatory molecules via inhibition of STAT3 activity but increased gene expression of molecules related to migration potential and immunomodulation in OA-MSCs. …”

Image_2_The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.TIF by Seon-yeong Lee (6067604)

“…STA21 significantly decreased expression of these proinflammatory molecules via inhibition of STAT3 activity but increased gene expression of molecules related to migration potential and immunomodulation in OA-MSCs. …”

Image_4_The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.TIF by Seon-yeong Lee (6067604)

“…STA21 significantly decreased expression of these proinflammatory molecules via inhibition of STAT3 activity but increased gene expression of molecules related to migration potential and immunomodulation in OA-MSCs. …”

Image_3_The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.TIF by Seon-yeong Lee (6067604)

“…STA21 significantly decreased expression of these proinflammatory molecules via inhibition of STAT3 activity but increased gene expression of molecules related to migration potential and immunomodulation in OA-MSCs. …”

Image_3_The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.TIF by Seon-yeong Lee (6067604)

“…STA21 significantly decreased expression of these proinflammatory molecules via inhibition of STAT3 activity but increased gene expression of molecules related to migration potential and immunomodulation in OA-MSCs. …”

Image_4_The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.TIF by Seon-yeong Lee (6067604)

“…STA21 significantly decreased expression of these proinflammatory molecules via inhibition of STAT3 activity but increased gene expression of molecules related to migration potential and immunomodulation in OA-MSCs. …”

DataSheet_1_PEAK Mood, Mind, and Marks: a pilot study of an intervention to support university students’ mental and cognitive health through physical exercise.docx by Catherine E. B. Brown (17943147)

“…Students exercise frequency decreased; however, these figures are likely a conservative estimate of students exercise engagement. …”

DataSheet1_The application of Tong-fu therapeutic method on ulcerative colitis: A systematic review and meta-analysis for efficacy and safety of rhubarb-based therapy.docx by Yuzheng Li (3430058)

“…In addition, although rhubarb has side effect, the results of our analysis showed that rhubarb-based therapy did not exhibit significant side effects. This means it has a high safety profile in clinical use. …”

Dipeptidyl dipeptidase-4 inhibitor recovered ischemia through an increase in vasculogenic endothelial progenitor cells and regeneration-associated cells in diet-induced obese mice by Amankeldi A. Salybekov (6018689)

“…Lineage profiling of isolated cells from ischemic tissues revealed that MK-0626 administration has an inhibitory effect on unproductive inflammation. This occurred via a decrease in the influx of total blood cells and pro-inflammatory cells such as neutrophils, total macrophages, M1, total T-cells, cytotoxic T-cells, and B-cells, with a concomitant increase in number of regeneration-associated cells, such as M2/M ratio and T_reg/T-helper. …”