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18301
Storable, Dual-Component Systems for Frontal Ring-Opening Metathesis Polymerization
Published 2022“…Mechanistic analysis of a related model system demonstrated that an excess Cu reagent decreases the activation and polymerization rates.…”
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18302
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18303
Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors
Published 2018“…<div><p>The regulation of translation initiation factor 2 (eIF2) is important for erythroid survival and differentiation. Lack of iron, a critical component of heme and hemoglobin, activates Heme Regulated Inhibitor (HRI). …”
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18304
A Novel sLRP6E1E2 Inhibits Canonical Wnt Signaling, Epithelial-to-Mesenchymal Transition, and Induces Mitochondria-Dependent Apoptosis in Lung Cancer
Published 2012“…We designed a Wnt antagonist sLRP6E1E2, and generated a replication-incompetent adenovirus (Ad), dE1-k35/sLRP6E1E2, and a replication-competent oncolytic Ad, RdB-k35/sLRP6E1E2, both expressing sLRP6E1E2. sLRP6E1E2 prevented Wnt-mediated stabilization of cytoplasmic β-catenin, decreased Wnt/β-catenin signaling and cell proliferation via the mitogen-activated protein kinase, and phosphatidylinositol 3-kinase pathways. sLRP6E1E2 induced apoptosis, cytochrome <em>c</em> release, and increased cleavage of PARP and caspase-3. sLRP6E1E2 suppressed growth of the human lung tumor xenograft, and reduced motility and invasion of cancer cells. …”
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18305
Supplementary Material for: Colonization of Streptococcus pyogenes is associated with functional dyspepsia and exacerbates functional dyspepsia in mice by inhibiting the RhoA/ROCK1...
Published 2025“…Conclusion:The study confirmed the pathogenic role of skin Streptococcus in FD and the therapeutic value of electroacupuncture at Tianshu acupoint, potentially via RhoA/ROCK1 signaling pathway regulation.…”
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18306
A Cytotoxic Type III Secretion Effector of <em>Vibrio parahaemolyticus</em> Targets Vacuolar H<sup>+</sup>-ATPase Subunit c and Ruptures Host Cell Lysosomes
Published 2012“…During the infection of mammalian cells, this pathogen exhibits cytotoxicity that is dependent on its type III secretion system (T3SS1). VepA, an effector protein secreted via the T3SS1, plays a major role in the T3SS1-dependent cytotoxicity of <em>V. parahaemolyticus</em>. …”
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18307
Table2_The causal effect of Alzheimer’s disease and family history of Alzheimer’s disease on non-ischemic cardiomyopathy and left ventricular structure and function: a Mendelian ra...
Published 2024“…MH-AD was also strongly associated with a decreased risk of NICM (OR 0.8958, 95% CI 0.8449–0.9498, p = 0.0002). …”
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18308
Table1_The causal effect of Alzheimer’s disease and family history of Alzheimer’s disease on non-ischemic cardiomyopathy and left ventricular structure and function: a Mendelian ra...
Published 2024“…MH-AD was also strongly associated with a decreased risk of NICM (OR 0.8958, 95% CI 0.8449–0.9498, p = 0.0002). …”
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18309
Data_Sheet_1_Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke.PDF
Published 2020“…Both in vivo and in vitro results showed that the expression of METTL3 protein, m6A and miR-335 was significantly decreased with the reperfusion period. …”
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18310
A range of fits to the human data set across different tuning parameter values with the top 1% of outliers displayed using the method presented in the main text for human data.
Published 2025“…<p>With decreasing <i>λ</i> values, we see new demes being implicated as outliers in the fit, that disappear with a very low <i>λ</i> value. …”
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18311
Data_Sheet_2_Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke.PDF
Published 2020“…Both in vivo and in vitro results showed that the expression of METTL3 protein, m6A and miR-335 was significantly decreased with the reperfusion period. …”
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18312
Data_Sheet_3_Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke.PDF
Published 2020“…Both in vivo and in vitro results showed that the expression of METTL3 protein, m6A and miR-335 was significantly decreased with the reperfusion period. …”
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18313
DataSheet_1_A novel gene SpCTP3 from the hyperaccumulator Sedum plumbizincicola redistributes cadmium and increases its accumulation in transgenic Populus × canescens.docx
Published 2023“…Our results suggest that overexpressing SpCTP3 in transgenic poplar plants promotes Cd accumulation, modulates Cd distribution and ROS homeostasis, and decreases Cd toxicity via organic acids. In conclusion, genetically modifying plants to overexpress SpCTP3 may be a viable strategy for improving the phytoremediation of Cd-polluted soil.…”
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18314
Datasheet1_Exposure to outdoor artificial light at night and breast cancer risk: a population-based case-control study in two French departments (the CECILE study).pdf
Published 2023“…</p>Methods<p>Data from a French population-based case-control study, including 1,185 incident breast cancer cases and 1,282 controls enrolled in 2005–2007, were used. …”
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18315
A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ...
Published 2017“…To ascertain which metabolic pathways are used to convert glucose and glutamine to balanced energy and biomass production, we performed systematic constraint-based simulations of a model of human central metabolism. Sampling of the feasible flux space allowed us to obtain a large number of randomly mutated cells simulated at different glutamine and glucose uptake rates. …”
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18316
A model with two target-cell populations and viral competition in one of these populations matches <i>in vivo</i> data and predicts that R5 inhibitors accelerate AIDS onset.
Published 2009“…R5 inhibitors clearly accelerate AIDS-onset for a large fraction of parameter space. (D) Time-dependency of X4 emergence as a function of CCR5 inhibitor efficacy (α-CCR5 efficacy) in the “competitive regime.” …”
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18317
Nitrogen Limitation of Pond Ecosystems on the Plains of Eastern Colorado
Published 2014“…<div><p>Primary production in freshwater ecosystems is often limited by the availability of phosphorus (P), nitrogen (N), or a combination of both (NP co-limitation). While N fixation via heterocystous cyanobacteria can supply additional N, no comparable mechanism for P exists; hence P is commonly considered to be the predominant and ultimate limiting nutrient in freshwater ecosystems. …”
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18318
Structure, Heat Capacity, and High-Temperature Thermal Properties of Yb<sub>14</sub>Mn<sub>1−<i>x</i></sub>Al<sub><i>x</i></sub>Sb<sub>11</sub>
Published 2009“…A series of compounds, Yb<sub>14</sub>Mn<sub>1−-<i>x</i></sub>Al<sub><i>x</i></sub>Sb<sub>11</sub> with (0 < <i>x</i> < 1), was prepared via Sn flux and the structures investigated. …”
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18319
Assessing environmental attributes and effects of climate change on <i>Sphagnum</i> peatland distributions in North America using single- and multi-species models
Published 2017“…Peatlands are maintained via greater plant productivity (especially of <i>Sphagnum</i> species) than decomposition, and the processes involved are strongly mediated by climate. …”
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18320
Table_1_Disentangling transport movement patterns of trucks either transporting pigs or while empty within a swine production system before and during the COVID-19 epidemic.docx
Published 2023“…Furthermore, we observed a decrease in connectivity in 2020 compared with 2019, as indicated by the majority of network parameter values. …”