Supplementary information files for: Bioengineered model of the human motor unit with physiologically functional neuromuscular junctions by Rowan Rimington (5074733)

“…Spontaneous firing was significantly elevated in 3D motor units, confirmed to be driven by the motor nerve via antagonistic inhibition of the AChR. Functional analysis outlined decreased time to peak twitch and half relaxation times, indicating enhanced physiology of excitation contraction coupling in innervated motor units. …”

Table_1_SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt–STAT5–Trib1 Circuit in Pseudomonas aeruginosa Infection.xls by Shugang Qin (8591460)

“…Inhibiting SHIP-1 via siRNA silencing resulted in lipid raft aggregates, aggravated oxidative damage, and bacterial burden in macrophages after PAO1 infection. …”

Data_Sheet_1.DOCX by Jian Li (41607)

“…</p><p>Results: MGF significantly decreased liver triglyceride and free fatty acid levels, increased sirtuin-1 (SIRT-1) and AMPK phosphorylation in KK-A^y mice. …”

MicroRNA-195 Inhibits the Proliferation of Human Glioma Cells by Directly Targeting Cyclin D1 and Cyclin E1 by Wang Hui (8544)

“…<div><p>Glioma proliferation is a multistep process during which a sequence of genetic and epigenetic alterations randomly occur to affect the genes controlling cell proliferation, cell death and genetic stability. microRNAs are emerging as important epigenetic modulators of multiple target genes, leading to abnormal cellular signaling involving cellular proliferation in cancers.In the present study, we found that expression of miR-195 was markedly downregulated in glioma cell lines and human primary glioma tissues, compared to normal human astrocytes and matched non-tumor associated tissues. …”

Data Sheet 1_Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats.pdf by Mohamed Osman Abdalrahem Essa (21562583)

“…Probiotic bacteria Enterococcus faecium and Bacteroides fragilis were administered via oral gavage at a concentration of (1 × 10⁹) CFU/mL for five consecutive days. …”

DataSheet1_Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.PDF by Yuanyuan Liu (136992)

“…<p>Idiopathic pulmonary fibrosis is a progressive fatal disease characterized by interstitial remodeling, with high lethality and a lack of effective medical therapies. …”

Data Sheet 1_High humidity environment increases FBG by impairing the intestinal barrier.zip by Yao Wang (102387)

“…This study aimed to investigate the impact of a high humidity environment (HH) on fasting blood glucose (FBG), intestinal barrier integrity, and gut microbiota composition.…”

Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery by Lishuai Feng (8053409)

“…Moreover, the detailed mechanism of ischemic stroke therapy <i>via</i> MPBzyme@NCM uptake by microglia was further studied, including microglia polarization toward M2, reduced recruitment of neutrophils, decreased apoptosis of neurons, and proliferation of neural stem cells, neuronal precursors, and neurons. …”

Table_3_Dietary Eggshell Membrane Powder Improves Survival Rate and Ameliorates Gut Dysbiosis in Interleukin-10 Knockout Mice.XLSX by Yongshou Yang (6822419)

“…Alpha diversity analysis of the microbiota revealed that ESM supplementation significantly increased gut microbial diversity, which was decreased in IL10^−/− mice. The Firmicutes/Bacteroidetes ratio was recovered to a normal level by ESM supplementation, suggesting that ESM helps maintain the compositional balance of the gut microbiota. …”

Upregulation of the Coagulation Factor VII Gene during Glucose Deprivation Is Mediated by Activating Transcription Factor 4 by Katherine R. Cronin (146594)

“…Of five coagulation protein genes examined, only <em>F7</em> was upregulated, suggesting that its functions may be important in a systemic response to glucose deprivation stress.…”

Data_Sheet_1_Profilin 2 and Endothelial Exosomal Profilin 2 Promote Angiogenesis and Myocardial Infarction Repair in Mice.docx by Zhenkun Li (739015)

“…Taken together, our findings demonstrate that PFN2 and exosomal PFN2 promote EC proliferation, migration, and tube formation through the PI3K-PFN2-ERK axis. Exosomal PFN2 may be a valuable target in the repair of MI injury via angiogenesis.…”

Image2_An insight into carcinogenic activity and molecular mechanisms of Bis(2-ethylhexyl) phthalate.jpeg by Gelsomina Pillo (9615383)

“…<p>Di(ethylhexyl) phthalate (DEHP) is a ubiquitous environmental contaminant to which humans are exposed via multiple routes. …”

DataSheet_2_The protective role of caffeic acid on bovine mammary epithelial cells and the inhibition of growth and biofilm formation of Gram-negative bacteria isolated from clinic... by Tianle Xu (250085)

“…CA was found to disrupt the biofilm formation of E. coli B1 in a sub-minimum inhibitory concentration (sub-MIC) and inhibited the adherence property of E. coli on bMECs by decreasing the staining of bacteria on cell surfaces in vitro. …”

Table 4_Human umbilical cord mesenchymal stem cells recover chemotherapy-induced premature ovarian failure.xlsx by Guojie Ji (21518650)

“…POF mice were established via injecting cyclophosphamide (CTX) plus busulfan (BU). …”

Data_Sheet_1_Expression of Na+/K+-ATPase Was Affected by Salinity Change in Pacific abalone Haliotis discus hannai.DOC by Yanglei Jia (646337)

“…Therefore, the sudden salinity changes may affect NKA transcription activation, translation and enzyme activity via a cAMP-mediated pathway.</p>…”

N-Linked Glycosylation Supports Cross-Talk between Receptor Tyrosine Kinases and Androgen Receptor by Harri M. Itkonen (415967)

“…<div><p>Prostate cancer is the second most common cause of cancer-associated deaths in men and signalling via a transcription factor called androgen receptor (AR) is an important driver of the disease. …”

The Extracellular Matrix of <i>Candida albicans</i> Biofilms Impairs Formation of Neutrophil Extracellular Traps by Chad J. Johnson (171725)

“…The clinical relevance of the role for extracellular matrix in diminishing NET production was corroborated in vivo using a rat catheter model. The <i>C</i>. <i>albicans pmr1Δ/Δ</i>, defective in production of matrix mannan, appeared to elicit a greater abundance of NETs by scanning electron microscopy imaging, which correlated with a decreased fungal burden. …”

Image_1_Neurotransmitters Affect Larval Development by Regulating the Activity of Prothoracicotropic Hormone-Releasing Neurons in Drosophila melanogaster.TIF by Shun Hao (11848871)

“…We also identified that PTTH neurons were excited by ACh application ex vivo in a dose-dependent manner via ionotropic nicotinic ACh receptors. …”

Image_4_MicroRNA-5112 Targets IKKγ to Dampen the Inflammatory Response and Improve Clinical Symptoms in Both Bacterial Infection and DSS-Induced Colitis.tif by Xilong Kang (2548195)

“…The overexpression of miR-5112 decreased inflammatory cytokine production, accompanied by a reduction of IKKγ in flagellin-stimulated BMDCs. …”

Table_3_Association mapping uncovers maize ZmbZIP107 regulating root system architecture and lead absorption under lead stress.xlsx by Fengxia Hou (13861286)

“…Excessive Pb in soils affects crop yield and quality, thus threatening human health via the food chain. Herein, we investigated Pb tolerance among a maize association panel using root bushiness (BSH) under Pb treatment as an indicator. …”