DataSheet_1_Inhibition of Anti-Inflammatory Macrophage Phenotype Reduces Tumour Growth in Mouse Models of Brain Metastasis.pdf by Vasiliki Economopoulos (339957)

“…Further, pharmacological inhibition of the anti-inflammatory BDM and/or microglial phenotypes, via either Colony Stimulating Factor 1 Receptor (CSF-1R) or STAT6 pathways, significantly decreased tumour burden in two different syngeneic mouse models of breast cancer brain metastasis. …”

Seasonal dynamics in mosquito emergence changes the adult mosquito age distribution. by Isaac J. Stopard (10151370)

“…<p>(A) The temporal dynamics in mosquito abundance from single simulations assuming the mean adult, female mosquito emergence rate is either time-invariant (perennial dynamics) or follows a sine wave with a single period per year (one peak dynamics). …”

Data_Sheet_2_Admixture Has Shaped Romani Genetic Diversity in Clinically Relevant Variants.XLSX by Neus Font-Porterias (4809177)

“…However, the study of clinically relevant mutations has a Eurocentric bias. The Romani, the largest transnational minority ethnic group in Europe, originated in South Asia and received extensive gene flow from West Eurasia. …”

Data_Sheet_1_Admixture Has Shaped Romani Genetic Diversity in Clinically Relevant Variants.DOCX by Neus Font-Porterias (4809177)

“…However, the study of clinically relevant mutations has a Eurocentric bias. The Romani, the largest transnational minority ethnic group in Europe, originated in South Asia and received extensive gene flow from West Eurasia. …”

Morphology and composition of the internal axis in two morphologically contrasting deep-water sea pens (Cnidaria: Octocorallia) by Bárbara de Moura Neves (4988150)

“…Axes’ cross-sectional areas also decreased with distance from the base in both species, being the largest near the base. …”

The Tissue-Specific Rep8/UBXD6 Tethers p97 to the Endoplasmic Reticulum Membrane for Degradation of Misfolded Proteins by Louise Madsen (205192)

“…In addition, p97 plays a central role in degradation of misfolded secretory proteins via the ER-associated degradation pathway. …”

PowerPoint Slides for: Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients by Locatelli F. (3698788)

“…<p><b><i>Background:</i></b> Anemia, a common complication of chronic kidney disease (CKD), has previously been attributed primarily to decreased production of erythropoietin. …”

Optimization of DC-PCR for drug screening. by Sergei Vatolin (138253)

“…After completion of thermal cycling samples were first analyzed under UV light (Left panel), then via agarose-gel electrophoresis (Right panel). Using gel-based detection, the level of detection for epigenetic differences of CDKN2A was lower, down to about 1 cell for site #6 compared to about 300 cells with direct UV transillumination. …”

Dependence of Storage Capacity on Noise Strength <i>r</i>₃ for different values of Potential Width <i>C</i>. by Yu Feng (445691)

“…However, for larger values of <i>C</i> (e.g., <i>C</i> = 4, 5), the storage capacity first increases with noise intensity, reaches a peak and then decreases. …”

The number of primary care visits among children younger than 20 years of age per calendar-month from 1 January 2005 to 31 December 2015. by Elias Eythorsson (5820515)

“…Panels B and C suggest that the number of both AOM visits and all other visits decreased in the post-vaccine period, and that AOM visits decreased to a larger degree.…”

Hyperspecialized pathogenic species evolution. by Kalliopi Georgiades (199075)

“…<p>The circles with various colors represent different bacteria; the small brown circles represent the gene repertoire; the arrows around the bacteria represent gene exchange; the leaf, mouth and lungs represent the different potential niches colonized by a species. The red circle is a hyperspecialized bacterium with a decreased gene repertoire <i>via</i> gene loss.…”

Supplementary Material for: Thyroid hormone clearance in the paraventricular nucleus of male mice regulates lean mass and physical activity by Wu Z. (4429111)

“…We accomplished DIO3 genetic inactivation via stereotaxic injection of the AAV-cre vector into adult mice homozygous for a “floxed” Dio3 allele. …”

Table 1_Simultaneous regulation of both lignin and cellulose biosynthesis modifies xylem fiber properties in Populus.xlsx by Jian Li (41607)

“…</p>Results and discussion<p>The transgenic plants exhibited decreased lignin content and a significant increase in cellulose content. …”

Table_1_Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyeli... by Yi Ban (6477029)

“…Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a MHC class I-like molecule. Myelin, which is mostly composed of β-Galcer, has been long considered as an immunologically-inert neuron insulator, because the antigen-binding cleft of CD1d is highly α-form-restricted.…”

Video_1_Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyeli... by Yi Ban (6477029)

“…Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a MHC class I-like molecule. Myelin, which is mostly composed of β-Galcer, has been long considered as an immunologically-inert neuron insulator, because the antigen-binding cleft of CD1d is highly α-form-restricted.…”

Video_3_Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyeli... by Yi Ban (6477029)

“…Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a MHC class I-like molecule. Myelin, which is mostly composed of β-Galcer, has been long considered as an immunologically-inert neuron insulator, because the antigen-binding cleft of CD1d is highly α-form-restricted.…”

Video_4_Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyeli... by Yi Ban (6477029)

“…Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a MHC class I-like molecule. Myelin, which is mostly composed of β-Galcer, has been long considered as an immunologically-inert neuron insulator, because the antigen-binding cleft of CD1d is highly α-form-restricted.…”

Data_Sheet_1_Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalo... by Yi Ban (6477029)

“…Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a MHC class I-like molecule. Myelin, which is mostly composed of β-Galcer, has been long considered as an immunologically-inert neuron insulator, because the antigen-binding cleft of CD1d is highly α-form-restricted.…”

Video_2_Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyeli... by Yi Ban (6477029)

“…Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a MHC class I-like molecule. Myelin, which is mostly composed of β-Galcer, has been long considered as an immunologically-inert neuron insulator, because the antigen-binding cleft of CD1d is highly α-form-restricted.…”

Data_Sheet_1_Seed- and leaf-based expression of FGF21-transferrin fusion proteins for oral delivery and treatment of non-alcoholic steatohepatitis.docx by Hsuan-Wu Hou (13878566)

“…The fibroblast growth factor 21 (FGF21) can reverse this liver dysfunction, but requires targeted delivery to the liver, which can be achieved via oral administration. Therefore, we fused FGF21 to transferrin (Tf) via a furin cleavage site (F), to promote uptake from the intestine into the portal vein, yielding FGF21-F-Tf, and established its production in both seeds and leaves of commercial Nicotiana tabacum cultivars, compared their expression profile and tested the bioavailability and bioactivity in feeding studies. …”