Image_8_TP53-Activated lncRNA GHRLOS Regulates Cell Proliferation, Invasion, and Apoptosis of Non-Small Cell Lung Cancer by Modulating the miR-346/APC Axis.tif by Ke Ren (34504)

“…In summary, this study reveals lncRNA GHRLOS, upregulated by TP53, acts as a molecule sponge of miR-346 to cooperatively modulates expression of APC, a miR-346 target, and potentially inhibits NSCLC progression via TP53/lncRNA GHRLOS/miR-346/APC axis, which represents a novel pathway that could be useful in targeted therapy against NSCLC.…”

Image_2_Two new and effective food-extracted immunomodulatory agents exhibit anti-inflammatory response activity in the hACE2 acute lung injury murine model of COVID-19.tif by Shasha Liu (1754584)

“…This study aims to investigate the effects of two food-extracted immunomodulatory agents, ajoene-enriched garlic extract (AGE) and cruciferous vegetables-extracted sulforaphane (SFN), on anti-inflammatory and immune responses in a SARS-CoV-2 acute lung injury mouse model.</p>Methods<p>In this study, we established a mouse model to mimic the SARS-CoV-2 infection acute lung injury model via intratracheal injection of polyinosinic:polycytidylic acid (poly[I:C]) and SARS-CoV-2 recombinant spike protein (SP). …”

Low temperature reduces byssus adhesion of highly invasive golden mussels: Influencing mechanisms and antifouling implications by Miaolian Zhang (21974951)

“…Low-temperature treatment offers a promising alternative for freshwater antifouling; however, its underlying mechanisms remain poorly understood. …”

Model of supercoiling-coupled transcription. by Boaz Goldberg (22601119)

“…<p>(A) Model setup. For transcription, we consider the following fives aspects: (1) initiation, a single step process dependent on SC; (2) elongation, which introduces positive and negative supercoils downstream and upstream respectively; it occurs at a constant rate except when stalled under extreme supercoiling levels; (3) termination, which occurs instantaneously and produces a single RNA transcript; (4) topoisomerase activities, including gyrase and TopoI; and (5) RNA degradation, which occurs via a Poisson process. …”

Image_1_Hematopoietic-Specific Deletion of Foxo1 Promotes NK Cell Specification and Proliferation.pdf by Pei Huang (1821661)

“…The reason for Foxo1 suppressing NK cell proliferation might be its direct transcription of the cell-cycle inhibitory genes, such as p21^cip1, p27^kip1, p130, Gadd45a, and Ccng2 (cyclin G2) in NK cells, supported by the evidence of decreased mRNA expression of p21^cip1, p27^kip1, p130, Gadd45a, and Ccng2 in Foxo1-deficient NK cells and direct binding of Foxo1 on their promoter region. …”

Image_1_Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5′-Monophosphate-Activated Protein Kinase.pdf by Ren-shi Li (6423038)

“…<p>Background: Pulmonary fibrosis (PF) is a devastating interstitial lung disease and characterized by an abnormal accumulation of extracellular matrix (ECM). …”

Image_2_Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5′-Monophosphate-Activated Protein Kinase.pdf by Ren-shi Li (6423038)

“…<p>Background: Pulmonary fibrosis (PF) is a devastating interstitial lung disease and characterized by an abnormal accumulation of extracellular matrix (ECM). …”

Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis <i>in vitro</i> and <i>in vivo</i> by Hongrui Cui (12001906)

“…<p>Acute kidney injury (AKI) is a common complication of sepsis and increase morbidity and mortality. …”

S1 File - by Yaqin Hu (661123)

“…MiR-204-5p expression was measured via RT‒qPCR. The SIRT1 agonist RSV and a miR-204-5p inhibitor were used to study changes in ER stress (ERS), proliferation, and apoptosis in HEI-OC1 cells. …”

Increased 14-3-3β and γ protein isoform expressions in parasitic eosinophilic meningitis caused by <i>Angiostrongylus cantonensis</i> infection in mice by Hung-Chin Tsai (673178)

“…</p><p>Mice were orally infected with 50 <i>A</i>. <i>cantonensis</i> L3 via an oro-gastric tube and sacrificed every week for 3 consecutive weeks after infection. …”

Crz signaling modulates energy and osmotic homeostasis. by Meet Zandawala (491178)

“…Crz modulates the release of CAPA from Va neurons, which in turn affects chill-coma recovery and desiccation tolerance via its effect on the renal tubules. CAPA is also acting on AKH-producing cells (APCs) and the gut, as shown in [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009425#pgen.1009425.ref061" target="_blank">61</a>]. …”

Deletion or mutation of <i>FEN1</i> improves fitness of gut-colonizing <i>C</i>. <i>glabrata</i> during caspofungin (CSF) treatment. by Yasmine Hassoun (10761963)

“…<p><b>A.</b> Gut-colonizing <i>fen1</i> mutants survive during CSF therapy better than the isogenic wild type strain. …”

Validation of both the dose and infused patterns of CORT within the circulation of the rat. by Benjamin P. Flynn (11256176)

“…(D) 1 ml of CORT (3.84 μM) was delivered intravenously over 3 hrs in a PULS manner (dashed line) via 20 min (grey bar), hourly CORT infusions at a rate of 1 ml/ hr, whilst the CONS (solid line) rate of 0.33 ml was maintained throughout the experimental period. …”

Image1_PACAP regulates VPAC1 expression, inflammatory processes and lipid homeostasis in M1- and M2-macrophages.tiff by Roman Witzel (17140549)

“…Therefore, VPAC1 agonists or PACAP may represent a new class of anti-atherogenic therapeutics.</p>…”

Image_1_Brain-Derived Microparticles (BDMPs) Contribute to Neuroinflammation and Lactadherin Reduces BDMP Induced Neuroinflammation and Improves Outcome After Stroke.JPEG by Zhili Chen (2812762)

“…Adult male C57BL/6J mice were subjected to dMCAo and treated via tail vein injection at 3 h after stroke with: (A) +PBS (n = 5/group); (B) +BDMPs (1.5 × 10⁸, n = 6/group); (C) +Lactadherin (400 μg/kg, n = 5/group); (D) +BDMP+Lactadherin (n = 6/group). …”

Image2_PACAP regulates VPAC1 expression, inflammatory processes and lipid homeostasis in M1- and M2-macrophages.tiff by Roman Witzel (17140549)

“…Therefore, VPAC1 agonists or PACAP may represent a new class of anti-atherogenic therapeutics.</p>…”

DataSheet1_Functional characterization of SGLT1 using SSM-based electrophysiology: Kinetics of sugar binding and translocation.pdf by Andre Bazzone (3169068)

“…Based on our findings we propose an 11-state kinetic model, introducing a random binding order and intermediate states corresponding to the electrogenic transitions detected via SSME upon substrate binding.…”

Data Sheet 1_Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins.xlsx by Yu Chen (29959)

“…Interestingly, NcGRA7 formed a complex with the prohibitins PHB1 and PHB2. Using inhibitors of PHB1 or transfecting N. caninum-infected THP-1 cells with PHB1 siRNA significantly decreased IL-1β production, but not TNF-α.…”

Table 1_Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins.docx by Yu Chen (29959)

“…Interestingly, NcGRA7 formed a complex with the prohibitins PHB1 and PHB2. Using inhibitors of PHB1 or transfecting N. caninum-infected THP-1 cells with PHB1 siRNA significantly decreased IL-1β production, but not TNF-α.…”

Table_1_Insights into melatonin-induced photosynthetic electron transport under low-temperature stress in cucumber.xlsx by Pei Wu (327833)

“…These results suggest that appropriate MT concentration (100 μmol · L^-1) can improve the photosynthetic performance of PS II and electron transport from primary quinone electron acceptor (Q_A) to secondary quinone electron acceptor (Q_B), promote the balance of energy distribution, strengthen the connectivity of PSI and PSII, improve the electron flow of PSII via Q_A to PC⁺ and P₇₀₀⁺ from reaching PSI by regulating multiple sites of electron transport chain in photosynthesis, and increase the pool size and reduction rates of PSI in low temperature-stressed cucumber plants, All these modifications by MT 100 treatment promoted the photosynthetic electron transfer smoothly, and further restored the cucumber plant growth under low temperature stress. …”