Image2_Posaconazole inhibits the stemness of cancer stem-like cells by inducing autophagy and suppressing the Wnt/β-catenin/survivin signaling pathway in glioblastoma.JPEG by Hua Wang (13530)

“…In summary, this work provides an experimental foundation for exploiting POS as a CSCs-targeting antitumor drug for GBM treatment.…”

Data Sheet 3_Protective effect of Shenqi Wenfei Formula against lipopolysaccharide/cigarette smoke-induced COPD in Rat based on gut microbiota and network pharmacology analysis.zip by Mengyao Shi (10053288)

“…Introduction<p>The incidence of chronic obstructive pulmonary disease (COPD) appears to be increasing and evidence suggests that the intestinal flora may play a causative role in its development. Previous studies found that the Shenqi Wenfei Formula (SQWF) can regulate pyroptosis via the NLRP3/GSDMD pathway, thereby reducing the inflammatory response in the lungs of COPD model rats. …”

Presentation_1_LCS-1 inhibition of superoxide dismutase 1 induces ROS-dependent death of glioma cells and degradates PARP and BRCA1.pptx by Min Ling (161785)

“…An innovative therapeutic strategy had been developed via inducing ROS-dependent cell death by targeting antioxidant proteins. …”

Image_2_Caffeic Acid Phenethyl Ester Ameliorates Calcification by Inhibiting Activation of the AKT/NF-κB/NLRP3 Inflammasome Pathway in Human Aortic Valve Interstitial Cells.tif by Ming Liu (105953)

“…<p>Calcific aortic valve disease (CAVD) occurs via a pathophysiological process that includes inflammation-induced osteoblastic differentiation of aortic valvular interstitial cells (AVICs). …”

Table_2_Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors.XLSX by Gourav Bhardwaj (206574)

“…<p>Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. Here, we show that while muscle-specific deletion of IR or IGF1R individually results in only modest changes in the muscle transcriptome, combined deletion of IR/IGF1R (MIGIRKO) altered > 3000 genes, including genes involved in mitochondrial dysfunction, fibrosis, cardiac hypertrophy, and pathways related to estrogen receptor, protein kinase A (PKA), and calcium signaling. …”

Image_1_Tremor suppression following treatment with MRgFUS: skull density ratio consistency and degree of posterior dentatorubrothalamic tract lesioning predicts long-term clinical... by Kain Kyle (15350116)

“…</p>Methods<p>We retrospectively analysed data from 31 subjects with ET, treated with MRgFUS at a single centre. Tremor severity was assessed with parts A, B and C of the Clinical Rating Scale for Tremor (CRST) as well as the combined CRST. …”

Table_4_Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.xlsx by Mark E. Pepin (8122907)

“…<p>Decreased serum adiponectin levels in type 2 diabetes has been linked to the onset of mitochondrial dysfunction in diabetic complications by impairing AMPK-SIRT1-PGC-1α signaling via impaired adiponectin receptor 1 (AdipoR1) signaling. …”

Data_Sheet_1_Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells.docx by Junping Yin (839507)

“…This study revealed that (i) cigarette smoking is associated with an increased expression of ACE2 and TMPRSS2 and a decreased expression of cathepsin L; (ii) significant alternations in expression of ACE2, TMPRSS2, and cathepsin L were observed between current smokers and former smokers, but not between former smokers and never smokers; (iii) when compared with healthy controls with identical smoking status, patients with COPD or lung cancer showed negligible changes in expression of ACE2, TMPRSS2, and cathepsin L. …”

DataSheet_1_The submandibular and sublingual glands maintain oral microbial homeostasis through multiple antimicrobial proteins.docx by Yanan Li (94033)

“…Introduction<p>Oral microbial homeostasis is a key factor affecting oral health, and saliva plays a significant role in maintaining oral microbial homeostasis. …”

DataSheet_1_Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology.pdf by Kehan Li (413697)

“…Then, regression analyses indicated that 9 prognostic genes (including ANPEP, OAS1, SCGB1A1, HLA‐A, NPPB, FGB, CCL2, TLR4, and SERPINE1) might play important roles in quercetin for treating UCEC/COVID-19. …”

Image_4_Skin repair and immunoregulatory effects of myeloid suppressor cells from human cord blood in atopic dermatitis.tiff by Chang-Hyun Kim (441400)

“…Our findings support the potential of hUCB-MDSCs as a novel treatment strategy for AD.</p>…”

Data Sheet 4_Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions.pdf by Kyle D. Gromer (9955082)

“…Ly6c+ macrophages in murine BA showed increased expression for Hif1a and other genes involved in the cellular response to hypoxia. …”

Image_3_Integration of mRNA and miRNA Analysis Reveals the Molecular Mechanism of Cotton Response to Salt Stress.JPEG by Jingjing Zhan (1878034)

“…<p>To identify the regulatory network of known and novel microRNAs (miRNAs) and their targets responding to salt stress, a combined analysis of mRNA libraries, small RNA libraries, and degradome libraries were performed. …”

Table_3_Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1.xlsx by Mark E. Pepin (8122907)

“…<p>Decreased serum adiponectin levels in type 2 diabetes has been linked to the onset of mitochondrial dysfunction in diabetic complications by impairing AMPK-SIRT1-PGC-1α signaling via impaired adiponectin receptor 1 (AdipoR1) signaling. …”

DataSheet3_Oral Lisinopril Raises Tissue Levels of ACE2, the SARS-CoV-2 Receptor, in Healthy Male and Female Mice.docx by Steven D. Brooks (12223484)

“…Mice received lisinopril (10 mg/kg/day), losartan (10 mg/kg/day), or both for 21 days via drinking water. A control group received water without drug. …”

Image_3_Skin repair and immunoregulatory effects of myeloid suppressor cells from human cord blood in atopic dermatitis.tiff by Chang-Hyun Kim (441400)

“…Our findings support the potential of hUCB-MDSCs as a novel treatment strategy for AD.</p>…”

Image4_Posaconazole inhibits the stemness of cancer stem-like cells by inducing autophagy and suppressing the Wnt/β-catenin/survivin signaling pathway in glioblastoma.JPEG by Hua Wang (13530)

“…In summary, this work provides an experimental foundation for exploiting POS as a CSCs-targeting antitumor drug for GBM treatment.…”

Image 1_Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma.jpeg by Nana Wang (533812)

“…</p>Conclusion<p>LRFN4 may serve as a novel prognostic biomarker for LUAD, shows specific overexpression in LUAD and may be a potential therapeutic target for LUAD patients.…”

Image_2_Classification of Estrogen Receptor-Positive Breast Cancer Based on Immunogenomic Profiling and Validation at Single-Cell Resolution.TIF by Xianxiong Ma (4276441)

“…Moreover, C2 was associated with a lower tumor mutation burden, a decreased neoantigen load, and fewer CNVs. …”

Intraflagellar Transport Gene Expression Associated with Short Cilia in Smoking and COPD by Justina Hessel (511099)

“…To assess these hypotheses, airway epithelium was obtained via bronchoscopic brushing. Cilia length was assessed by measuring 100 cilia (10 cilia on each of 10 cells) per subject and Affymetrix microarrays were used to evaluate IFT gene expression in nonsmokers and healthy smokers in 2 independent data sets from large and small airway as well as in COPD smokers in a data set from the small airway. …”