The Prolyl Isomerase Pin1 Modulates Development of CD8+ cDC in Mice by Theresa J. Barberi (189449)

“…</p> <h3>Conclusions/Significance</h3><p>We have identified a novel role for Pin1 as a modulator of CD8+ cDC development. …”

Image_6_OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.tif by Longwei Xu (655781)

“…</p>Conclusions<p>OX40 may play a critical role in the progress of OVA-induced EGE by promoting the maturation and function of eosinophils via the Traf2/6-related NF-κB signaling pathway.…”

Table_1_Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors.XLSX by Gourav Bhardwaj (206574)

“…<p>Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. Here, we show that while muscle-specific deletion of IR or IGF1R individually results in only modest changes in the muscle transcriptome, combined deletion of IR/IGF1R (MIGIRKO) altered > 3000 genes, including genes involved in mitochondrial dysfunction, fibrosis, cardiac hypertrophy, and pathways related to estrogen receptor, protein kinase A (PKA), and calcium signaling. …”

Data Sheet 3_Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions.pdf by Kyle D. Gromer (9955082)

“…Ly6c+ macrophages in murine BA showed increased expression for Hif1a and other genes involved in the cellular response to hypoxia. …”

Data Sheet 1_FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels.docx by Yongyan Song (4415074)

“…Genotyping of rs9939609 and rs17817449 was performed via polymerase chain reaction-restriction fragment length polymorphism. …”

Table_6_Classification of Estrogen Receptor-Positive Breast Cancer Based on Immunogenomic Profiling and Validation at Single-Cell Resolution.XLSX by Xianxiong Ma (4276441)

“…Moreover, C2 was associated with a lower tumor mutation burden, a decreased neoantigen load, and fewer CNVs. …”

An Epitope-Substituted DNA Vaccine Improves Safety and Immunogenicity against Dengue Virus Type 2 by Chung-Tao Tang (764646)

“…<div><p>Dengue virus (DENV), a global disease, is divided into four serotypes (DENV1-4). …”

Image_2_OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.tif by Longwei Xu (655781)

“…</p>Conclusions<p>OX40 may play a critical role in the progress of OVA-induced EGE by promoting the maturation and function of eosinophils via the Traf2/6-related NF-κB signaling pathway.…”

Probing the Soft and Nanoductile Mechanical Nature of Single and Polycrystalline Organic–Inorganic Hybrid Perovskites for Flexible Functional Devices by Jingui Yu (3389084)

“…The observed limited brittle fracture behavior is attributed to the transformation of partial edge dislocations to disordered atoms (nanovoid formation). A significant plastic deformation region is observed when nanovoids enlarge and coalesce with adjacent ones, which ultimately leads to crack propagations <i>via</i> ionic-chain breaking. …”

The effects of IL-10 gene polymorphism on serum, and gingival crevicular fluid levels of IL-6 and IL-10 in chronic periodontitis by Hulya Toker (4894579)

“…<div><p>Abstract Objective Anti-inflammatory cytokines play a crucial role in periodontitis by inhibiting synthesis of pro-inflammatory cytokines. …”

Table_1_Proteome Profiling of Cerebral Vessels in Rhesus Macaques: Dysregulation of Antioxidant Activity and Extracellular Matrix Proteins Contributes to Cerebrovascular Aging in R... by Xia Wang (36364)

“…<p>Aging is a major risk factor for cerebrovascular disease; however, the molecular mechanisms of cerebrovascular aging remain to be clarified. …”

Image_1_Optical Control of CD8+ T Cell Metabolism and Effector Functions.pdf by Andrea M. Amitrano (10915356)

“…Strong metabolic suppression in the TME is often associated with impaired T cell recruitment to the tumor site and hyporesponsive effector function via T cell exhaustion. Increasing evidence suggests that mitochondria play a key role in CD8⁺ T cell activation, effector function, and persistence in tumors. …”

Image quality scores from GAN harmonization. by Shruti Atul Mali (21300851)

“…Reproducibility and stability were assessed via the Concordance Correlation Coefficient (CCC) and pairwise comparisons using paired stability tests. …”

Data_Sheet_1_New Insight Into the Mechanism of Ecological Effects of Artificial Habitats: Elucidating the Relationship Between Protists Associated With Artificial Reefs and Adjacen... by Ruolin Li (519115)

“…In conclusion, protist communities in WAR may provide food sources for AR-associated heterotrophic protists. A variety of key phyla associated with ARs have biological roles in the carbon pump via their ecological characteristics.…”

Image_1_Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese ob/ob Mice.J... by Akimichi Saito (10772010)

“…Invariant natural killer T (iNKT) cells are unique subset of T lymphocytes and have a crucial role in atherogenesis. However, it remains unclear whether iNKT cells also impact on the development of AAA. …”

Table_1_H2S Alleviates Salinity Stress in Cucumber by Maintaining the Na+/K+ Balance and Regulating H2S Metabolism and Oxidative Stress Response.DOC by Jing-Long Jiang (6740723)

“…Emerging evidence suggests that hydrogen sulfide (H₂S), as a versatile signal molecule, can ameliorate salt stress-induced adverse effects. …”

Data Sheet 6_Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions.pdf by Kyle D. Gromer (9955082)

“…Ly6c+ macrophages in murine BA showed increased expression for Hif1a and other genes involved in the cellular response to hypoxia. …”

Image_4_Classification of Estrogen Receptor-Positive Breast Cancer Based on Immunogenomic Profiling and Validation at Single-Cell Resolution.TIF by Xianxiong Ma (4276441)

“…Moreover, C2 was associated with a lower tumor mutation burden, a decreased neoantigen load, and fewer CNVs. …”

Image_1_PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.TIF by Jing Li (10611)

“…In addition, PRDX2 down-regulation promoted the protein levels of p-p38, p-JNK, and p-ERK, which was confirmed in relevant MAPK inhibitor treatment experiments. Our results suggest a protective role of PRDX2, as a scavenger of ROS, in AS progression through inhibiting the VSMC phenotype alteration and function via MAPK signaling pathway.…”

NK Cells of Kidney Transplant Recipients Display an Activated Phenotype that Is Influenced by Immunosuppression and Pathological Staging by Ulrike Hoffmann (765425)

“…Upon <i>in vitro</i> stimulation <i>via</i> Ca⁺⁺-dependent signals, down-modulation of CD16 was associated with induction of interferon (IFN)-γ expression. …”