Video2_The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning.mp4 by Le-le Zhang (477674)

“…</p>Methods<p>We successfully constructed a fear- formation model by foot-shock. Four days after foot-shock, microglial capacity of synaptic pruning was investigated via western blotting, immunofluorescence and Golgi-Cox staining. …”

Image_1_Application of hot water and cold air to reduce bacterial contamination on broiler carcasses.TIF by Anja Beterams (19699861)

“…<p>Two physical treatments (heat via water bath and cold air) with various temperatures (20/70/75/80°C and − 80/−90°C) and exposure times (20, 30, 40 s) were carried out to identify a decontaminating effect on zoonotic pathogens on broiler carcasses. …”

Image2_Rice lipid transfer protein, OsLTPL23, controls seed germination by regulating starch-sugar conversion and ABA homeostasis.TIF by Quanlin Li (516061)

“…Transcript profiles in the germinating seeds exhibited that the abscisic acid (ABA)-responsive genes, OsABI3 and OsABI5, and biosynthesis genes, OsNCED1, OsNCED2, OsNCED3 and OsNCED4, are obviously upregulated in the osltpl23 mutants compared to NIP plants, conversely, ABA metabolism genes OsABA8ox1, OsABA8ox2 and OsABA8ox3 are stepwise decreased. Further investigations found that osltpl23 mutants displays weakened early seedling growth, with elevated gene expresssion of ABA catabolism genes and repressive transcription response of defence-related genes OsWRKY45, OsEiN3, OsPR1a, OsPR1b and OsNPR1. …”

CEACAM3 signaling is required for the PMN cytokine response to <i>N. gonorrhoeae</i>. by Anna Sintsova (437622)

“…<p>Inhibition of Src-family kinases and Syk leads to decreased cytokine production by infected PMNs. (<b>A, B</b>) WT and CEABAC PMNs were left untreated or pre-incubated with (<b>A</b>) Src-family kinase inhibitor (PP2, 10 µM), or (<b>B</b>) Syk inhibitor (piceatannol, 50 µM). …”

Video4_The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning.mp4 by Le-le Zhang (477674)

“…</p>Methods<p>We successfully constructed a fear- formation model by foot-shock. Four days after foot-shock, microglial capacity of synaptic pruning was investigated via western blotting, immunofluorescence and Golgi-Cox staining. …”

Apolipoprotein B48, the Structural Component of Chylomicrons, Is Sufficient to Antagonize <i>Staphylococcus aureus </i>Quorum-Sensing by Bradley O. Elmore (282347)

“…ApoB48- and apoB100-LP inhibited <i>agr</i> activation with IC50s of 3.5 and 2.3 nM, respectively, demonstrating a conserved AIP binding site. Importantly, apoB48-LP antagonized QS, limited morbidity and promoted bacterial clearance in a mouse model of <i>S</i>. …”

DataSheet_3_Identifying Biomarkers from Transcriptomic Signatures in Renal Allograft Biopsies Using Deceased and Living Donors.docx by Bin Yang (103252)

“…These DEGs reflected donor injury and acute immune responses associated with inflammation and cell death as early as at 30 minutes, which could be a precious window of potential intervention. DEGs at 3 months mainly represented the changes of adaptive immunity, immunosuppressive treatment, remodeling or fibrosis via different networks and signaling pathways. …”

DataSheet1_Rosmarinic Acid Ameliorates Pulmonary Ischemia/Reperfusion Injury by Activating the PI3K/Akt Signaling Pathway.docx by Wenbin Luo (571520)

“…Together, our results demonstrate the beneficial role of RA in pulmonary IR injury via PI3K/Akt-mediated anti-oxidation and anti-apoptosis, which could be a promising therapeutic intervention for pulmonary IR injury.…”

Ultramicroelectrode Studies of Self-Terminated Nickel Electrodeposition and Nickel Hydroxide Formation upon Water Reduction by Nicole L. Ritzert (1306581)

“…As the layer coalesces, further metal deposition is quenched while H₂O reduction continues, albeit at a decreased rate as fewer of the most reactive sites, e.g., Ni/Ni­(OH)₂ island edges, are available. …”

Image3_Rosmarinic Acid Ameliorates Pulmonary Ischemia/Reperfusion Injury by Activating the PI3K/Akt Signaling Pathway.tif by Wenbin Luo (571520)

“…Together, our results demonstrate the beneficial role of RA in pulmonary IR injury via PI3K/Akt-mediated anti-oxidation and anti-apoptosis, which could be a promising therapeutic intervention for pulmonary IR injury.…”

DataSheet1_D-Cysteine Ethyl Ester Reverses the Deleterious Effects of Morphine on Breathing and Arterial Blood–Gas Chemistry in Freely-Moving Rats.docx by Paulina M. Getsy (11465254)

“…Morphine (10 mg/kg, IV) also A-a gradient, which caused a mismatch in ventilation perfusion within the lungs, and elicited pronounced changes in arterial blood–gas chemistry, including pronounced decreases in arterial blood pH, pO₂ and sO₂, and equally pronounced increases in pCO₂ (all responses indicative of decreased ventilatory drive). …”

Data: Experimental confirmation of effects of leaf litter type and light on tadpole performance for two priority amphibians by Angela K. Burrow (10283935)

“…Shading had a nominal and inconsistent effect on Gopher frog growth rates, but did extend larval periods in all litter treatments, decreased survival in all litter treatments except oak, and decreased mass at metamorphosis in all litter treatments except pine and sweetgum. …”

Image_2_Longitudinal Changes in the Composition of the Penile Microbiome Are Associated With Circumcision Status, HIV and HSV-2 Status, Sexual Practices, and Female Partner Microbi... by Supriya D. Mehta (7919309)

“…BV was positively associated with the relative abundance of numerous individual penile taxa. The decreased Bray–Curtis similarity was more common for men with HSV-2, and HSV-2 was also associated with a lower relative abundance of Corynebacterium and Staphylococcus.…”

Image 1_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.tif by Xinyu Sun (426009)

“…Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”

Image_3_CLEC4s as Potential Therapeutic Targets in Hepatocellular Carcinoma Microenvironment.TIF by Yinjiang Zhang (5030006)

“…However, the expression of CLEC4A, CLEC4D, CLEC4E, CLEC4J (FCER2), CLEC4K (CD207), CLEC4G, CLEC4H1, CLEC4M, and CLEC4H2 decreased with tumor progression. …”

The selector gene midline controls ventral leg pattern by both inhibiting Dpp signaling and specifying ventral fate by Lindsay Phillips (8728574)

“…The T-box transcription factor gene <i>midline (mid)</i> (fly Tbx20) acts as a selector gene, causing cells to adopt a ventral pattern instead of dorsal. …”

Image 5_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.tif by Xinyu Sun (426009)

“…Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”

Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice by Jin-Ran Chen (207037)

“…Their decreased mRNA expression was confirmed by real-time PCR and standard ChIP analysis, indicating a strong association with <i>Ezh2</i> mediated H3K27me3 epigenetic changes. …”

Image_5_CLEC4s as Potential Therapeutic Targets in Hepatocellular Carcinoma Microenvironment.TIF by Yinjiang Zhang (5030006)

“…However, the expression of CLEC4A, CLEC4D, CLEC4E, CLEC4J (FCER2), CLEC4K (CD207), CLEC4G, CLEC4H1, CLEC4M, and CLEC4H2 decreased with tumor progression. …”

Data_Sheet_1_Effects of cannabidiol, with and without ∆9-tetrahydrocannabinol, on anxiety-like behavior following alcohol withdrawal in mice.docx by Mariam Melkumyan (18844264)

“…Immunohistochemical analysis showed decreased S100β and Iba1 cell counts in the CeA at 4-h withdrawal, but not at 24-h withdrawal, with CBD and CBD:THC reversing alcohol withdrawal effects..…”