Image5_Modification of Fibronectin by Non-Enzymatic Glycation Impairs K+ Channel Function in Rat Cerebral Artery Smooth Muscle Cells.JPEG by Yan Yang (33204)

“…Compared with baseline, native FN enhanced whole cell K⁺ current in a concentration-dependent manner, whereas gFN inhibited basal current. …”

Image 3_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in... by Xingke Song (21372995)

“…</p>Methods<p>A depressive-like behavior model was established via intraperitoneal injection of LPS, and rats were randomly assigned to a normal group, a model group, and a taVNS intervention group. …”

Table_1_Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk.xlsx by Grace Liang (4398046)

“…The objective of this study was to determine whether engaging in a regular exercise program in a real world clinical setting mediates cardiovascular protection via modulation of non-traditional risk factors, such as those involved in coagulation, inflammation and metabolic regulation.…”

Image_4_Blocking P2Y2 purinergic receptor prevents the development of lipopolysaccharide-induced acute respiratory distress syndrome.jpg by Zahra Kargarpour (11721834)

“…Altogether, our findings imply for the first time that increased endogenous ATP concentration via activation of P2RY2 is related to the pathogenesis of LPS-induced lung inflammation and may represent a potential therapeutic target for the treatment of ARDS and predictably assess new treatments in ARDS.…”

DataSheet_1_Blocking P2Y2 purinergic receptor prevents the development of lipopolysaccharide-induced acute respiratory distress syndrome.docx by Zahra Kargarpour (11721834)

“…Altogether, our findings imply for the first time that increased endogenous ATP concentration via activation of P2RY2 is related to the pathogenesis of LPS-induced lung inflammation and may represent a potential therapeutic target for the treatment of ARDS and predictably assess new treatments in ARDS.…”

Image1_Modification of Fibronectin by Non-Enzymatic Glycation Impairs K+ Channel Function in Rat Cerebral Artery Smooth Muscle Cells.JPEG by Yan Yang (33204)

“…Compared with baseline, native FN enhanced whole cell K⁺ current in a concentration-dependent manner, whereas gFN inhibited basal current. …”

Image_1_Modest Gains After an 8-Week Exercise Program Correlate With Reductions in Non-traditional Markers of Cardiovascular Risk.pdf by Grace Liang (4398046)

“…The objective of this study was to determine whether engaging in a regular exercise program in a real world clinical setting mediates cardiovascular protection via modulation of non-traditional risk factors, such as those involved in coagulation, inflammation and metabolic regulation.…”

DataSheet_1_Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression.pdf by Hyewon Choi (687527)

“…Newly synthesized β-Hp is loaded into EVs in early endosomes via a KFERQ-like motif and then secreted from CCA cells to induce tumor progression. …”

Data_Sheet_1_Identification of Genetic Signature Associated With Aging in Pulmonary Fibrosis.xlsx by Yanjiao Lu (1639285)

“…Through the comparisons of aged and young BIPF mice, a total number of 778 aging-associated DEGs were identified, with 453 genes increased and 325 genes decreased. …”

Table_1_Identification of Genetic Signature Associated With Aging in Pulmonary Fibrosis.DOCX by Yanjiao Lu (1639285)

“…Through the comparisons of aged and young BIPF mice, a total number of 778 aging-associated DEGs were identified, with 453 genes increased and 325 genes decreased. …”

Typical Time Courses of the Number of Active Receptor Complexes upon Addition of TGF-β by Jose M. G Vilar (27466)

“…</p><p>(F) Behavior of the model with the same parameter values as in (A), with the exception of the efficiency of recycling of active receptors that has been decreased to <i>α =</i> 0.5. …”

DataSheet1_Synthesis of β-Enaminonitrile-Linked 8-Methoxy-1H-Benzo[f]Chromene Moieties and Analysis of Their Antitumor Mechanisms.docx by Menna Elgaafary (11736509)

“…<p>A series of aryl-substituted 3-amino-1-aryl-8-methoxy-1H-benzo[f]chromene-2-carbonitriles (4a–4q) were designed and synthesized via reaction of 6-methoxy-2-naphthol with a mixture of appropriate aromatic aldehydes and malononitrile under microwave conditions. …”

<i>LSM12</i> deletion posttranscriptionally down-regulates <i>EPAC1</i> expression. by Jongbo Lee (9914603)

“…(C) <i>LSM12</i> deletion posttranscriptionally decreases <i>EPAC1</i> expression via the 5′ UTR. Control and <i>LSM12</i>^KO cells were co-transfected with each <i>EPAC1</i> reporter and a FLUC expression vector (normalizing control). …”

Image2_Hesperidin protects rats’ liver and kidney from oxidative damage and physiological disruption induced by nickel oxide nanoparticles.PNG by Ahmed Abd-Eltawab Tammam (12521617)

“…The first group served as a Control group. For 8 weeks, the second group was administered NiO-NPs (100 mg/kg/day), and the third group was given HSP (100 mg/kg/day) via oral gavage for both groups. …”

Reduced mitochondrial function and protein expression in 21-28wk-old R14^Δ/+ mice. by Brian Foo (19273132)

“…<p>A-D) Mitochondrial function measured in left- and right-ventricular cardiomyocytes isolated from 28wk-old ♂ WT and R14^Δ/+ mice (N = 5–7). …”

Image1_Hesperidin protects rats’ liver and kidney from oxidative damage and physiological disruption induced by nickel oxide nanoparticles.PNG by Ahmed Abd-Eltawab Tammam (12521617)

“…The first group served as a Control group. For 8 weeks, the second group was administered NiO-NPs (100 mg/kg/day), and the third group was given HSP (100 mg/kg/day) via oral gavage for both groups. …”

Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction by Safiedeen, Zainab

“…These results provide a novel molecular insight into the manner MPs mediate vascular dysfunction and allow identification of potential therapeutic targets to treat vascular complications associated with metabolic syndrome.…”
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Structure–activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro by Hammad, Ayat S.

“…An in vitro model of ER stress was developed using tunicamycin, and the compounds of interest were screened for their effect on cell viability, and the expression of ER chaperone GRP78, the pro-apoptotic ER stress marker CHOP, and apoptotic caspases 3 and 12 (via western blotting). Our findings indicate that exposure to tunicamycin (0.5 μg/mL) for 2 h induces the expression of GRP78 and CHOP, and apoptotic markers (caspase-3 and caspase-12) and causes a significant reduction in renal cell viability. …”
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Table_1_Integrated transcriptomics and metabolomics analysis provide insight into the resistance response of rice against brown planthopper.xlsx by Shaojie Shi (5546837)

“…</p>Methods<p>Here, we conducted a transcriptomic and metabolomic analysis of Bph30-transgenic (BPH30T) and BPH-susceptible Nipponbare plants to elucidate the response of Bph30 to BPH infestation.…”

Image_3_Integrative Analysis of LGR5/6 Gene Variants, Gut Microbiota Composition and Osteoporosis Risk in Elderly Population.tif by Dong-sheng Di (11634688)

“…The rs10920362 CT/TT genotype associated with a decreased relative abundance of Actinobacteria (β = −1.32, P < 0.001), Bifidobacteriaceae (β = −1.70, P < 0.001), and Bifidobacterium (β = −1.70, P < 0.001) compared to the CC genotype.…”